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Status of sperm morphology assessment: an evaluation of methodology and clinical value.
Fertil Steril 2015; 103(1):53-8FS

Abstract

OBJECTIVE

To characterize methodological changes in sperm morphology assessment and to correlate sperm morphology with clinical outcome.

DESIGN

In this observational study, sperm morphology profiles of patients were analyzed. The percentages of morphologically normal spermatozoa were evaluated with respect to changes in morphology assessment criteria; male aging; and prognostic value for outcomes after in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI).

SETTING

Diagnostic and clinical laboratories.

PATIENT(S)

A total of 8,846 men who visited the diagnostic laboratory; 133 samples from a sperm bank; and 3,676 IVF/ICSI couples.

INTERVENTION(S)

None.

MAIN OUTCOME MEASURE(S)

The percentage of morphologically normal spermatozoa in semen samples. The regression of the individual morphologically normal cell profiles. The relation between the percentage of normal forms with pregnancy outcome after IVF/ICSI.

RESULT(S)

The percentage of morphologically normal spermatozoa showed a decrease from roughly 30%-80% in 1984 to 0%-10% since 2004. With added evidence from sperm bank samples, this decrease was found to be attributable mainly to changes in morphology assessment criteria. Furthermore, an intraindividual aging effect of 0.51% per year was observed. A statistically significant relationship was found between decreases in percentage of normal forms and a lower probability of ongoing pregnancies after IVF, although the area under the curve was only 54%.

CONCLUSION(S)

Methodological changes had a strong effect on the percentage of morphologically normal spermatozoa over the past few decades. In addition, male aging results in decreasing sperm morphology. The percentage of morphologically normal spermatozoa has no prognostic value for individual IVF/ICSI patients.

Authors+Show Affiliations

Fertility Laboratory, Department of Obstetrics and Gynaecology, Radboud University Medical Centre, Nijmegen, the Netherlands. Electronic address: Leonie.vandenHoven@Radboudumc.nl.Department for Health Evidence, Radboud University Medical Centre, Nijmegen, the Netherlands.Fertility Laboratory, Department of Obstetrics and Gynaecology, Radboud University Medical Centre, Nijmegen, the Netherlands.Fertility Laboratory, Department of Obstetrics and Gynaecology, Radboud University Medical Centre, Nijmegen, the Netherlands.Fertility Laboratory, Department of Obstetrics and Gynaecology, Radboud University Medical Centre, Nijmegen, the Netherlands.

Pub Type(s)

Journal Article
Observational Study

Language

eng

PubMed ID

25450299

Citation

van den Hoven, Leonie, et al. "Status of Sperm Morphology Assessment: an Evaluation of Methodology and Clinical Value." Fertility and Sterility, vol. 103, no. 1, 2015, pp. 53-8.
van den Hoven L, Hendriks JC, Verbeet JG, et al. Status of sperm morphology assessment: an evaluation of methodology and clinical value. Fertil Steril. 2015;103(1):53-8.
van den Hoven, L., Hendriks, J. C., Verbeet, J. G., Westphal, J. R., & Wetzels, A. M. (2015). Status of sperm morphology assessment: an evaluation of methodology and clinical value. Fertility and Sterility, 103(1), pp. 53-8. doi:10.1016/j.fertnstert.2014.09.036.
van den Hoven L, et al. Status of Sperm Morphology Assessment: an Evaluation of Methodology and Clinical Value. Fertil Steril. 2015;103(1):53-8. PubMed PMID: 25450299.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Status of sperm morphology assessment: an evaluation of methodology and clinical value. AU - van den Hoven,Leonie, AU - Hendriks,Jan C M, AU - Verbeet,Jozé G M, AU - Westphal,Johan R, AU - Wetzels,Alex M M, Y1 - 2014/10/24/ PY - 2014/06/17/received PY - 2014/09/23/revised PY - 2014/09/25/accepted PY - 2014/12/3/entrez PY - 2014/12/3/pubmed PY - 2015/4/15/medline KW - ICSI KW - IVF KW - Sperm morphology KW - male aging KW - prognostic value SP - 53 EP - 8 JF - Fertility and sterility JO - Fertil. Steril. VL - 103 IS - 1 N2 - OBJECTIVE: To characterize methodological changes in sperm morphology assessment and to correlate sperm morphology with clinical outcome. DESIGN: In this observational study, sperm morphology profiles of patients were analyzed. The percentages of morphologically normal spermatozoa were evaluated with respect to changes in morphology assessment criteria; male aging; and prognostic value for outcomes after in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI). SETTING: Diagnostic and clinical laboratories. PATIENT(S): A total of 8,846 men who visited the diagnostic laboratory; 133 samples from a sperm bank; and 3,676 IVF/ICSI couples. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): The percentage of morphologically normal spermatozoa in semen samples. The regression of the individual morphologically normal cell profiles. The relation between the percentage of normal forms with pregnancy outcome after IVF/ICSI. RESULT(S): The percentage of morphologically normal spermatozoa showed a decrease from roughly 30%-80% in 1984 to 0%-10% since 2004. With added evidence from sperm bank samples, this decrease was found to be attributable mainly to changes in morphology assessment criteria. Furthermore, an intraindividual aging effect of 0.51% per year was observed. A statistically significant relationship was found between decreases in percentage of normal forms and a lower probability of ongoing pregnancies after IVF, although the area under the curve was only 54%. CONCLUSION(S): Methodological changes had a strong effect on the percentage of morphologically normal spermatozoa over the past few decades. In addition, male aging results in decreasing sperm morphology. The percentage of morphologically normal spermatozoa has no prognostic value for individual IVF/ICSI patients. SN - 1556-5653 UR - https://www.unboundmedicine.com/medline/citation/25450299/Status_of_sperm_morphology_assessment:_an_evaluation_of_methodology_and_clinical_value_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0015-0282(14)02213-4 DB - PRIME DP - Unbound Medicine ER -