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White matter integrity and cognition in mild traumatic brain injury following motor vehicle accident.
Brain Res. 2014 Dec 03; 1591:86-92.BR

Abstract

The aim of this study is to explore the white matter structure integrity in patients with mild traumatic brain injury (mTBI) using diffusion tensor imaging (DTI), and to analyze the relationship between the white matter structure integrity and cognitive impairment of patients with mTBI. Twenty-five patients with mTBI and 25 healthy control subjects were studied with conventional MR imaging and diffusion tensor imaging. Fractional anisotropy (FA) and mean diffusivity (MD) maps of patients with mTBI were calculated and compared, with these control maps using tract-based spatial statistics (TBSS). Significantly lower fractional anisotropy was found in patients in the uncinate fasciculus, superior longitudinal fasciculus, inferior longitudinal fasciculus, and internal capsule. Mean diffusivity was significantly elevated in the body of corpus callosum, uncinate fasciculus, superior longitudinal fasciculus, and internal capsule in the mTBI group compared with the control group (P<0.05). The mTBI group showed a significant negative correlation between the elevated mean diffusivity of the uncinate fasciculus and the working memory index (WMI) (R(2)=0.51, P<0.05), and the internal capsule of MD values was significantly negatively related to processing speed index (PSI) (R(2)=0.45, P<0.05). There was a positive correlation between the FA value of the uncinate fasciculus and Mini Mental State Examination (MMSE) in the mTBI patient group (R(2)=0.36, P<0.05). TBSS analysis of DTI suggests that patients with mTBI have focal axonal injury, and the pathophysiology is significantly related to the MMSE and IQ of mTBI patients. Diffusion tensor imaging can be a powerful technique for in vivo detection of mTBI, and can help in the diagnosis of patients with mTBI.

Authors+Show Affiliations

Department of Radiology, Daping Hospital, Third Military Medical University, Chongqing 400042, China.Department of Radiology, Daping Hospital, Third Military Medical University, Chongqing 400042, China.Department of Radiology, Daping Hospital, Third Military Medical University, Chongqing 400042, China.Department 4th, Research Institute of Surgery, Third Military Medical University, Chongqing 400042, China.Department of Medical Image, College of Biomedical Engineering, Third Military Medical University, Chongqing 400038, China.Department of Medical Image, College of Biomedical Engineering, Third Military Medical University, Chongqing 400038, China.Department of Radiology, Daping Hospital, Third Military Medical University, Chongqing 400042, China. Electronic address: jellyhuangsci2@163.com.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25451093

Citation

Xiong, Kunlin, et al. "White Matter Integrity and Cognition in Mild Traumatic Brain Injury Following Motor Vehicle Accident." Brain Research, vol. 1591, 2014, pp. 86-92.
Xiong K, Zhu Y, Zhang Y, et al. White matter integrity and cognition in mild traumatic brain injury following motor vehicle accident. Brain Res. 2014;1591:86-92.
Xiong, K., Zhu, Y., Zhang, Y., Yin, Z., Zhang, J., Qiu, M., & Zhang, W. (2014). White matter integrity and cognition in mild traumatic brain injury following motor vehicle accident. Brain Research, 1591, 86-92. https://doi.org/10.1016/j.brainres.2014.10.030
Xiong K, et al. White Matter Integrity and Cognition in Mild Traumatic Brain Injury Following Motor Vehicle Accident. Brain Res. 2014 Dec 3;1591:86-92. PubMed PMID: 25451093.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - White matter integrity and cognition in mild traumatic brain injury following motor vehicle accident. AU - Xiong,Kunlin, AU - Zhu,Yongshan, AU - Zhang,Yulong, AU - Yin,Zhiyong, AU - Zhang,Jingna, AU - Qiu,Mingguo, AU - Zhang,Weiguo, Y1 - 2014/10/23/ PY - 2014/08/12/received PY - 2014/10/14/revised PY - 2014/10/15/accepted PY - 2014/12/3/entrez PY - 2014/12/3/pubmed PY - 2015/9/4/medline KW - Cognitive impairment KW - Diffuse axonal injury KW - Diffusion tensor imaging KW - Fractional anisotropy KW - Mean diffusivity KW - Mild traumatic brain injury KW - Tract-based spatial statistics SP - 86 EP - 92 JF - Brain research JO - Brain Res VL - 1591 N2 - The aim of this study is to explore the white matter structure integrity in patients with mild traumatic brain injury (mTBI) using diffusion tensor imaging (DTI), and to analyze the relationship between the white matter structure integrity and cognitive impairment of patients with mTBI. Twenty-five patients with mTBI and 25 healthy control subjects were studied with conventional MR imaging and diffusion tensor imaging. Fractional anisotropy (FA) and mean diffusivity (MD) maps of patients with mTBI were calculated and compared, with these control maps using tract-based spatial statistics (TBSS). Significantly lower fractional anisotropy was found in patients in the uncinate fasciculus, superior longitudinal fasciculus, inferior longitudinal fasciculus, and internal capsule. Mean diffusivity was significantly elevated in the body of corpus callosum, uncinate fasciculus, superior longitudinal fasciculus, and internal capsule in the mTBI group compared with the control group (P<0.05). The mTBI group showed a significant negative correlation between the elevated mean diffusivity of the uncinate fasciculus and the working memory index (WMI) (R(2)=0.51, P<0.05), and the internal capsule of MD values was significantly negatively related to processing speed index (PSI) (R(2)=0.45, P<0.05). There was a positive correlation between the FA value of the uncinate fasciculus and Mini Mental State Examination (MMSE) in the mTBI patient group (R(2)=0.36, P<0.05). TBSS analysis of DTI suggests that patients with mTBI have focal axonal injury, and the pathophysiology is significantly related to the MMSE and IQ of mTBI patients. Diffusion tensor imaging can be a powerful technique for in vivo detection of mTBI, and can help in the diagnosis of patients with mTBI. SN - 1872-6240 UR - https://www.unboundmedicine.com/medline/citation/25451093/White_matter_integrity_and_cognition_in_mild_traumatic_brain_injury_following_motor_vehicle_accident_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-8993(14)01432-2 DB - PRIME DP - Unbound Medicine ER -