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Partial replacement of dietary linoleic acid with long chain n-3 polyunsaturated fatty acids protects against dextran sulfate sodium-induced colitis in rats.
Prostaglandins Leukot Essent Fatty Acids. 2014 Dec; 91(6):289-97.PL

Abstract

Imbalances in the dietary n-6 and n-3 polyunsaturated fatty acids have been implicated in the increased prevalence of inflammatory bowel disease. This study investigated the effects of substitution of linoleic acid with long chain n-3 polyunsaturated fatty acids and hence decreasing n-6:n-3 fatty acid ratio on inflammatory response in dextran sulfate sodium induced colitis. Male weanling Sprague Dawley rats were fed diets with n-6:n-3 fatty acid in the ratios of 215,50,10 or 5 for 3 months and colitis was induced by administration of dextran sulfate sodium in drinking water during last 11 days. Decreasing the dietary n-6:n-3 fatty acid ratio to 10 and 5 significantly attenuated the severity of colitis as evidenced by improvements in clinical symptoms, reversal of shortening of colon length, reduced severity of anemia, preservation of colonic architecture as well as reduced colonic mucosal myeloperoxidase activity. This protection was associated with suppression of colonic mucosal proinflammatory mediators such as TNFα, IL-1β and nitric oxide. These findings suggest that long chain n-3 polyunsaturated fatty acids at a level of 3.0 g/kg diet (n-6:n-3 ratio of 10) prevents dextran sulfate sodium induced colitis by suppressing the proinflammatory mediators.

Authors+Show Affiliations

Department of Lipid Chemistry, National Institute of Nutrition, Indian Council of Medical Research, Hyderabad, India.Department of Pathology, National Institute of Nutrition, Indian Council of Medical Research, Hyderabad, India.Department of Lipid Chemistry, National Institute of Nutrition, Indian Council of Medical Research, Hyderabad, India.Department of Lipid Chemistry, National Institute of Nutrition, Indian Council of Medical Research, Hyderabad, India.Department of Lipid Chemistry, National Institute of Nutrition, Indian Council of Medical Research, Hyderabad, India.Department of Lipid Chemistry, National Institute of Nutrition, Indian Council of Medical Research, Hyderabad, India. Electronic address: ahamed65@yahoo.co.in.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25451558

Citation

Tyagi, Anupama, et al. "Partial Replacement of Dietary Linoleic Acid With Long Chain N-3 Polyunsaturated Fatty Acids Protects Against Dextran Sulfate Sodium-induced Colitis in Rats." Prostaglandins, Leukotrienes, and Essential Fatty Acids, vol. 91, no. 6, 2014, pp. 289-97.
Tyagi A, Kumar U, Santosh VS, et al. Partial replacement of dietary linoleic acid with long chain n-3 polyunsaturated fatty acids protects against dextran sulfate sodium-induced colitis in rats. Prostaglandins Leukot Essent Fatty Acids. 2014;91(6):289-97.
Tyagi, A., Kumar, U., Santosh, V. S., Reddy, S., Mohammed, S. B., & Ibrahim, A. (2014). Partial replacement of dietary linoleic acid with long chain n-3 polyunsaturated fatty acids protects against dextran sulfate sodium-induced colitis in rats. Prostaglandins, Leukotrienes, and Essential Fatty Acids, 91(6), 289-97. https://doi.org/10.1016/j.plefa.2014.09.003
Tyagi A, et al. Partial Replacement of Dietary Linoleic Acid With Long Chain N-3 Polyunsaturated Fatty Acids Protects Against Dextran Sulfate Sodium-induced Colitis in Rats. Prostaglandins Leukot Essent Fatty Acids. 2014;91(6):289-97. PubMed PMID: 25451558.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Partial replacement of dietary linoleic acid with long chain n-3 polyunsaturated fatty acids protects against dextran sulfate sodium-induced colitis in rats. AU - Tyagi,Anupama, AU - Kumar,Uday, AU - Santosh,Vadakattu Sai, AU - Reddy,Suryam, AU - Mohammed,Saazida Bhanu, AU - Ibrahim,Ahamed, Y1 - 2014/09/28/ PY - 2014/05/07/received PY - 2014/09/05/revised PY - 2014/09/16/accepted PY - 2014/12/3/entrez PY - 2014/12/3/pubmed PY - 2015/7/25/medline KW - Dextran sulfate sodium KW - Inflammatory bowel disease KW - Long chain n-3 polyunsaturated fatty acids KW - Proinflammatory cytokines KW - Ulcerative colitis SP - 289 EP - 97 JF - Prostaglandins, leukotrienes, and essential fatty acids JO - Prostaglandins Leukot. Essent. Fatty Acids VL - 91 IS - 6 N2 - Imbalances in the dietary n-6 and n-3 polyunsaturated fatty acids have been implicated in the increased prevalence of inflammatory bowel disease. This study investigated the effects of substitution of linoleic acid with long chain n-3 polyunsaturated fatty acids and hence decreasing n-6:n-3 fatty acid ratio on inflammatory response in dextran sulfate sodium induced colitis. Male weanling Sprague Dawley rats were fed diets with n-6:n-3 fatty acid in the ratios of 215,50,10 or 5 for 3 months and colitis was induced by administration of dextran sulfate sodium in drinking water during last 11 days. Decreasing the dietary n-6:n-3 fatty acid ratio to 10 and 5 significantly attenuated the severity of colitis as evidenced by improvements in clinical symptoms, reversal of shortening of colon length, reduced severity of anemia, preservation of colonic architecture as well as reduced colonic mucosal myeloperoxidase activity. This protection was associated with suppression of colonic mucosal proinflammatory mediators such as TNFα, IL-1β and nitric oxide. These findings suggest that long chain n-3 polyunsaturated fatty acids at a level of 3.0 g/kg diet (n-6:n-3 ratio of 10) prevents dextran sulfate sodium induced colitis by suppressing the proinflammatory mediators. SN - 1532-2823 UR - https://www.unboundmedicine.com/medline/citation/25451558/Partial_replacement_of_dietary_linoleic_acid_with_long_chain_n_3_polyunsaturated_fatty_acids_protects_against_dextran_sulfate_sodium_induced_colitis_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0952-3278(14)00147-1 DB - PRIME DP - Unbound Medicine ER -