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Risk of cancer among women with polycystic ovary syndrome: a Danish cohort study.
Gynecol Oncol 2015; 136(1):99-103GO

Abstract

OBJECTIVE

To assess the association between polycystic ovary syndrome (PCOS) and cancer, especially of the endometrium, breast and ovary.

METHODS

The Danish National Patient Register was used to identify 12,070 in- and outpatients in whom PCOS was diagnosed when they were aged 9-49 years during 1977-2012. Using the Danish Cancer Registry, we followed the cohort through 2012 and compared the women's cancer incidence with that of the general Danish female population by means of standardized incidence ratios (SIRs).

RESULTS

Cancer was diagnosed in 279 women with PCOS (SIR = 1.19; 95% CI = 1.06-1.34). We found an almost fourfold increased risk for endometrial cancer (numbers observed (N) = 16, SIR = 3.9; 95% CI = 2.2-6.3), the large majority of cases being type 1 (N = 14, SIR = 4.7; 95% CI = 2.6-7.9). We found no association between PCOS and breast (N = 59, SIR = 1.1; 95% CI = 0.8-1.4) or ovarian cancer (N = 10, SIR = 1.8; 95% CI = 0.8-3.2); however, significantly increased risks were found for kidney, colon and brain cancers.

CONCLUSION

The results of this large cohort study support those of case-control studies showing that women with PCOS are at increased risk for endometrial cancer, whereas their risks for breast and ovarian cancer are similar to those of women in the general population. Our finding that women with PCOS also are at increased risk for cancers of the kidney, colon and brain requires further study.

Authors+Show Affiliations

Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Strandboulevarden 49, DK-2100 Copenhagen, Denmark.Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Strandboulevarden 49, DK-2100 Copenhagen, Denmark; Department of Gynecology, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, Copenhagen DK-2100, Denmark.Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Strandboulevarden 49, DK-2100 Copenhagen, Denmark.Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Strandboulevarden 49, DK-2100 Copenhagen, Denmark.Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Strandboulevarden 49, DK-2100 Copenhagen, Denmark. Electronic address: lene@cancer.dk.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25451694

Citation

Gottschau, Mathilde, et al. "Risk of Cancer Among Women With Polycystic Ovary Syndrome: a Danish Cohort Study." Gynecologic Oncology, vol. 136, no. 1, 2015, pp. 99-103.
Gottschau M, Kjaer SK, Jensen A, et al. Risk of cancer among women with polycystic ovary syndrome: a Danish cohort study. Gynecol Oncol. 2015;136(1):99-103.
Gottschau, M., Kjaer, S. K., Jensen, A., Munk, C., & Mellemkjaer, L. (2015). Risk of cancer among women with polycystic ovary syndrome: a Danish cohort study. Gynecologic Oncology, 136(1), pp. 99-103. doi:10.1016/j.ygyno.2014.11.012.
Gottschau M, et al. Risk of Cancer Among Women With Polycystic Ovary Syndrome: a Danish Cohort Study. Gynecol Oncol. 2015;136(1):99-103. PubMed PMID: 25451694.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risk of cancer among women with polycystic ovary syndrome: a Danish cohort study. AU - Gottschau,Mathilde, AU - Kjaer,Susanne Krüger, AU - Jensen,Allan, AU - Munk,Christian, AU - Mellemkjaer,Lene, Y1 - 2014/11/20/ PY - 2014/09/19/received PY - 2014/11/11/revised PY - 2014/11/15/accepted PY - 2014/12/3/entrez PY - 2014/12/3/pubmed PY - 2015/3/3/medline KW - All cancer sites KW - Breast cancer KW - Cohort study KW - Endometrial cancer KW - Ovarian cancer KW - Polycystic ovary syndrome SP - 99 EP - 103 JF - Gynecologic oncology JO - Gynecol. Oncol. VL - 136 IS - 1 N2 - OBJECTIVE: To assess the association between polycystic ovary syndrome (PCOS) and cancer, especially of the endometrium, breast and ovary. METHODS: The Danish National Patient Register was used to identify 12,070 in- and outpatients in whom PCOS was diagnosed when they were aged 9-49 years during 1977-2012. Using the Danish Cancer Registry, we followed the cohort through 2012 and compared the women's cancer incidence with that of the general Danish female population by means of standardized incidence ratios (SIRs). RESULTS: Cancer was diagnosed in 279 women with PCOS (SIR = 1.19; 95% CI = 1.06-1.34). We found an almost fourfold increased risk for endometrial cancer (numbers observed (N) = 16, SIR = 3.9; 95% CI = 2.2-6.3), the large majority of cases being type 1 (N = 14, SIR = 4.7; 95% CI = 2.6-7.9). We found no association between PCOS and breast (N = 59, SIR = 1.1; 95% CI = 0.8-1.4) or ovarian cancer (N = 10, SIR = 1.8; 95% CI = 0.8-3.2); however, significantly increased risks were found for kidney, colon and brain cancers. CONCLUSION: The results of this large cohort study support those of case-control studies showing that women with PCOS are at increased risk for endometrial cancer, whereas their risks for breast and ovarian cancer are similar to those of women in the general population. Our finding that women with PCOS also are at increased risk for cancers of the kidney, colon and brain requires further study. SN - 1095-6859 UR - https://www.unboundmedicine.com/medline/citation/25451694/Risk_of_cancer_among_women_with_polycystic_ovary_syndrome:_a_Danish_cohort_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0090-8258(14)01475-9 DB - PRIME DP - Unbound Medicine ER -