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Identifying statin-associated autoimmune necrotizing myopathy.
Cleve Clin J Med. 2014 Dec; 81(12):736-41.CC

Abstract

Statins up-regulate expression of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR), the rate-limiting enzyme in cholesterol synthesis and the major target of autoantibodies in statin-associated immune-mediated necrotizing myopathy. As muscle cells regenerate, they express high levels of HMGCR, which may sustain the immune response even after statin therapy is stopped. Awareness of this entity will help physicians who prescribe statins to take action to limit the associated morbidity.

Authors+Show Affiliations

Division of Rheumatology, Department of Medicine, and Instructor in Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.Director, Johns Hopkins Myositis Center, Division of Rheumatology, and Associate Professor, Johns Hopkins University School of Medicine, Baltimore, MD lchrist4@jhmi.edu.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

25452351

Citation

Albayda, Jemima, and Lisa Christopher-Stine. "Identifying Statin-associated Autoimmune Necrotizing Myopathy." Cleveland Clinic Journal of Medicine, vol. 81, no. 12, 2014, pp. 736-41.
Albayda J, Christopher-Stine L. Identifying statin-associated autoimmune necrotizing myopathy. Cleve Clin J Med. 2014;81(12):736-41.
Albayda, J., & Christopher-Stine, L. (2014). Identifying statin-associated autoimmune necrotizing myopathy. Cleveland Clinic Journal of Medicine, 81(12), 736-41. https://doi.org/10.3949/ccjm.81a.13158
Albayda J, Christopher-Stine L. Identifying Statin-associated Autoimmune Necrotizing Myopathy. Cleve Clin J Med. 2014;81(12):736-41. PubMed PMID: 25452351.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Identifying statin-associated autoimmune necrotizing myopathy. AU - Albayda,Jemima, AU - Christopher-Stine,Lisa, PY - 2014/12/3/entrez PY - 2014/12/3/pubmed PY - 2016/9/28/medline SP - 736 EP - 41 JF - Cleveland Clinic journal of medicine JO - Cleve Clin J Med VL - 81 IS - 12 N2 - Statins up-regulate expression of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR), the rate-limiting enzyme in cholesterol synthesis and the major target of autoantibodies in statin-associated immune-mediated necrotizing myopathy. As muscle cells regenerate, they express high levels of HMGCR, which may sustain the immune response even after statin therapy is stopped. Awareness of this entity will help physicians who prescribe statins to take action to limit the associated morbidity. SN - 1939-2869 UR - https://www.unboundmedicine.com/medline/citation/25452351/Identifying_statin_associated_autoimmune_necrotizing_myopathy_ L2 - https://www.ccjm.org/cgi/pmidlookup?view=long&pmid=25452351 DB - PRIME DP - Unbound Medicine ER -