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Fruit and vegetable consumption and risk of type 2 diabetes mellitus: a dose-response meta-analysis of prospective cohort studies.
Nutr Metab Cardiovasc Dis 2015; 25(2):140-7NM

Abstract

BACKGROUND AND AIMS

We conducted a dose-response meta-analysis to summarize the evidence from prospective cohort studies regarding the association of fruit and vegetable consumption with risk of type 2 diabetes mellitus (T2DM).

METHODS AND RESULTS

Pertinent studies were identified by searching Embase and PubMed through June 2014. Study-specific results were pooled using a random-effect model. The dose-response relationship was assessed by the restricted cubic spline model and the multivariate random-effect meta-regression. We standardized all data using a standard portion size of 106 g. The Relative Risk (95% confidence interval) [RR (95% CI)] of T2DM was 0.99 (0.98-1.00) for every 1 serving/day increment in fruit and vegetable (FV) (P = 0.18), 0.98 (0.95-1.01) for vegetable (P = 0.12), and 0.99 (0.97-1.00) for fruit (P = 0.05). The RR (95%CI) of T2DM was 0.99 (0.97-1.01), 0.98 (0.96-1.01), 0.97 (0.93-1.01), 0.96 (0.92-1.01), 0.96 (0.91-1.01) and 0.96 (0.91-1.01) for 1, 2, 3, 4, 5 and 6 servings/day of FV (P(for non-linearity) = 0.44). The T2DM risk was 0.96 (0.95-0.99), 0.94 (0.90-0.98), 0.94 (0.89-0.98), 0.96 (0.91-1.01), 0.98 (0.92-1.05) and 1.00 (0.93-1.08) for 1, 2, 3, 4, 5 and 6 servings/day of vegetable (P(for non-linearity) < 0.01). The T2DM risk was 0.95 (0.93-0.97), 0.91 (0.89-0.94), 0.88 (0.85-0.92), 0.92 (0.88-0.96) and 0.96 (0.92-1.01) for 0.5, 1, 2, 3 and 4 servings/day of fruit (P(for non-linearity) < 0.01).

CONCLUSIONS

Two-three servings/day of vegetable and 2 servings/day of fruit conferred a lower risk of T2DM than other levels of vegetable and fruit consumption, respectively.

Authors+Show Affiliations

Department of Epidemiology and Health Statistics, Qingdao University Medical College, Qingdao, PR China.Department of Epidemiology and Health Statistics, Qingdao University Medical College, Qingdao, PR China. Electronic address: zhangdf1962@aliyun.com.Department of Epidemiology and Health Statistics, Qingdao University Medical College, Qingdao, PR China.Department of Epidemiology and Health Statistics, Qingdao University Medical College, Qingdao, PR China.

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25456152

Citation

Wu, Y, et al. "Fruit and Vegetable Consumption and Risk of Type 2 Diabetes Mellitus: a Dose-response Meta-analysis of Prospective Cohort Studies." Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, vol. 25, no. 2, 2015, pp. 140-7.
Wu Y, Zhang D, Jiang X, et al. Fruit and vegetable consumption and risk of type 2 diabetes mellitus: a dose-response meta-analysis of prospective cohort studies. Nutr Metab Cardiovasc Dis. 2015;25(2):140-7.
Wu, Y., Zhang, D., Jiang, X., & Jiang, W. (2015). Fruit and vegetable consumption and risk of type 2 diabetes mellitus: a dose-response meta-analysis of prospective cohort studies. Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, 25(2), pp. 140-7. doi:10.1016/j.numecd.2014.10.004.
Wu Y, et al. Fruit and Vegetable Consumption and Risk of Type 2 Diabetes Mellitus: a Dose-response Meta-analysis of Prospective Cohort Studies. Nutr Metab Cardiovasc Dis. 2015;25(2):140-7. PubMed PMID: 25456152.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fruit and vegetable consumption and risk of type 2 diabetes mellitus: a dose-response meta-analysis of prospective cohort studies. AU - Wu,Y, AU - Zhang,D, AU - Jiang,X, AU - Jiang,W, Y1 - 2014/10/15/ PY - 2014/08/03/received PY - 2014/09/19/revised PY - 2014/10/06/accepted PY - 2014/12/3/entrez PY - 2014/12/3/pubmed PY - 2015/12/15/medline KW - Dose-response meta-analysis KW - Fruit KW - Prospective cohort studies KW - Type 2 diabetes mellitus KW - Vegetable SP - 140 EP - 7 JF - Nutrition, metabolism, and cardiovascular diseases : NMCD JO - Nutr Metab Cardiovasc Dis VL - 25 IS - 2 N2 - BACKGROUND AND AIMS: We conducted a dose-response meta-analysis to summarize the evidence from prospective cohort studies regarding the association of fruit and vegetable consumption with risk of type 2 diabetes mellitus (T2DM). METHODS AND RESULTS: Pertinent studies were identified by searching Embase and PubMed through June 2014. Study-specific results were pooled using a random-effect model. The dose-response relationship was assessed by the restricted cubic spline model and the multivariate random-effect meta-regression. We standardized all data using a standard portion size of 106 g. The Relative Risk (95% confidence interval) [RR (95% CI)] of T2DM was 0.99 (0.98-1.00) for every 1 serving/day increment in fruit and vegetable (FV) (P = 0.18), 0.98 (0.95-1.01) for vegetable (P = 0.12), and 0.99 (0.97-1.00) for fruit (P = 0.05). The RR (95%CI) of T2DM was 0.99 (0.97-1.01), 0.98 (0.96-1.01), 0.97 (0.93-1.01), 0.96 (0.92-1.01), 0.96 (0.91-1.01) and 0.96 (0.91-1.01) for 1, 2, 3, 4, 5 and 6 servings/day of FV (P(for non-linearity) = 0.44). The T2DM risk was 0.96 (0.95-0.99), 0.94 (0.90-0.98), 0.94 (0.89-0.98), 0.96 (0.91-1.01), 0.98 (0.92-1.05) and 1.00 (0.93-1.08) for 1, 2, 3, 4, 5 and 6 servings/day of vegetable (P(for non-linearity) < 0.01). The T2DM risk was 0.95 (0.93-0.97), 0.91 (0.89-0.94), 0.88 (0.85-0.92), 0.92 (0.88-0.96) and 0.96 (0.92-1.01) for 0.5, 1, 2, 3 and 4 servings/day of fruit (P(for non-linearity) < 0.01). CONCLUSIONS: Two-three servings/day of vegetable and 2 servings/day of fruit conferred a lower risk of T2DM than other levels of vegetable and fruit consumption, respectively. SN - 1590-3729 UR - https://www.unboundmedicine.com/medline/citation/25456152/Fruit_and_vegetable_consumption_and_risk_of_type_2_diabetes_mellitus:_a_dose_response_meta_analysis_of_prospective_cohort_studies_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0939-4753(14)00312-3 DB - PRIME DP - Unbound Medicine ER -