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Fruit and vegetable consumption and risk of type 2 diabetes mellitus: a dose-response meta-analysis of prospective cohort studies.

Abstract

BACKGROUND AND AIMS

We conducted a dose-response meta-analysis to summarize the evidence from prospective cohort studies regarding the association of fruit and vegetable consumption with risk of type 2 diabetes mellitus (T2DM).

METHODS AND RESULTS

Pertinent studies were identified by searching Embase and PubMed through June 2014. Study-specific results were pooled using a random-effect model. The dose-response relationship was assessed by the restricted cubic spline model and the multivariate random-effect meta-regression. We standardized all data using a standard portion size of 106 g. The Relative Risk (95% confidence interval) [RR (95% CI)] of T2DM was 0.99 (0.98-1.00) for every 1 serving/day increment in fruit and vegetable (FV) (P = 0.18), 0.98 (0.95-1.01) for vegetable (P = 0.12), and 0.99 (0.97-1.00) for fruit (P = 0.05). The RR (95%CI) of T2DM was 0.99 (0.97-1.01), 0.98 (0.96-1.01), 0.97 (0.93-1.01), 0.96 (0.92-1.01), 0.96 (0.91-1.01) and 0.96 (0.91-1.01) for 1, 2, 3, 4, 5 and 6 servings/day of FV (P(for non-linearity) = 0.44). The T2DM risk was 0.96 (0.95-0.99), 0.94 (0.90-0.98), 0.94 (0.89-0.98), 0.96 (0.91-1.01), 0.98 (0.92-1.05) and 1.00 (0.93-1.08) for 1, 2, 3, 4, 5 and 6 servings/day of vegetable (P(for non-linearity) < 0.01). The T2DM risk was 0.95 (0.93-0.97), 0.91 (0.89-0.94), 0.88 (0.85-0.92), 0.92 (0.88-0.96) and 0.96 (0.92-1.01) for 0.5, 1, 2, 3 and 4 servings/day of fruit (P(for non-linearity) < 0.01).

CONCLUSIONS

Two-three servings/day of vegetable and 2 servings/day of fruit conferred a lower risk of T2DM than other levels of vegetable and fruit consumption, respectively.

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  • Authors+Show Affiliations

    ,

    Department of Epidemiology and Health Statistics, Qingdao University Medical College, Qingdao, PR China.

    ,

    Department of Epidemiology and Health Statistics, Qingdao University Medical College, Qingdao, PR China. Electronic address: zhangdf1962@aliyun.com.

    ,

    Department of Epidemiology and Health Statistics, Qingdao University Medical College, Qingdao, PR China.

    Department of Epidemiology and Health Statistics, Qingdao University Medical College, Qingdao, PR China.

    Source

    MeSH

    Databases, Factual
    Diabetes Mellitus, Type 2
    Fruit
    Humans
    Risk Factors
    Vegetables

    Pub Type(s)

    Journal Article
    Meta-Analysis
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    25456152

    Citation

    Wu, Y, et al. "Fruit and Vegetable Consumption and Risk of Type 2 Diabetes Mellitus: a Dose-response Meta-analysis of Prospective Cohort Studies." Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, vol. 25, no. 2, 2015, pp. 140-7.
    Wu Y, Zhang D, Jiang X, et al. Fruit and vegetable consumption and risk of type 2 diabetes mellitus: a dose-response meta-analysis of prospective cohort studies. Nutr Metab Cardiovasc Dis. 2015;25(2):140-7.
    Wu, Y., Zhang, D., Jiang, X., & Jiang, W. (2015). Fruit and vegetable consumption and risk of type 2 diabetes mellitus: a dose-response meta-analysis of prospective cohort studies. Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, 25(2), pp. 140-7. doi:10.1016/j.numecd.2014.10.004.
    Wu Y, et al. Fruit and Vegetable Consumption and Risk of Type 2 Diabetes Mellitus: a Dose-response Meta-analysis of Prospective Cohort Studies. Nutr Metab Cardiovasc Dis. 2015;25(2):140-7. PubMed PMID: 25456152.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Fruit and vegetable consumption and risk of type 2 diabetes mellitus: a dose-response meta-analysis of prospective cohort studies. AU - Wu,Y, AU - Zhang,D, AU - Jiang,X, AU - Jiang,W, Y1 - 2014/10/15/ PY - 2014/08/03/received PY - 2014/09/19/revised PY - 2014/10/06/accepted PY - 2014/12/3/entrez PY - 2014/12/3/pubmed PY - 2015/12/15/medline KW - Dose-response meta-analysis KW - Fruit KW - Prospective cohort studies KW - Type 2 diabetes mellitus KW - Vegetable SP - 140 EP - 7 JF - Nutrition, metabolism, and cardiovascular diseases : NMCD JO - Nutr Metab Cardiovasc Dis VL - 25 IS - 2 N2 - BACKGROUND AND AIMS: We conducted a dose-response meta-analysis to summarize the evidence from prospective cohort studies regarding the association of fruit and vegetable consumption with risk of type 2 diabetes mellitus (T2DM). METHODS AND RESULTS: Pertinent studies were identified by searching Embase and PubMed through June 2014. Study-specific results were pooled using a random-effect model. The dose-response relationship was assessed by the restricted cubic spline model and the multivariate random-effect meta-regression. We standardized all data using a standard portion size of 106 g. The Relative Risk (95% confidence interval) [RR (95% CI)] of T2DM was 0.99 (0.98-1.00) for every 1 serving/day increment in fruit and vegetable (FV) (P = 0.18), 0.98 (0.95-1.01) for vegetable (P = 0.12), and 0.99 (0.97-1.00) for fruit (P = 0.05). The RR (95%CI) of T2DM was 0.99 (0.97-1.01), 0.98 (0.96-1.01), 0.97 (0.93-1.01), 0.96 (0.92-1.01), 0.96 (0.91-1.01) and 0.96 (0.91-1.01) for 1, 2, 3, 4, 5 and 6 servings/day of FV (P(for non-linearity) = 0.44). The T2DM risk was 0.96 (0.95-0.99), 0.94 (0.90-0.98), 0.94 (0.89-0.98), 0.96 (0.91-1.01), 0.98 (0.92-1.05) and 1.00 (0.93-1.08) for 1, 2, 3, 4, 5 and 6 servings/day of vegetable (P(for non-linearity) < 0.01). The T2DM risk was 0.95 (0.93-0.97), 0.91 (0.89-0.94), 0.88 (0.85-0.92), 0.92 (0.88-0.96) and 0.96 (0.92-1.01) for 0.5, 1, 2, 3 and 4 servings/day of fruit (P(for non-linearity) < 0.01). CONCLUSIONS: Two-three servings/day of vegetable and 2 servings/day of fruit conferred a lower risk of T2DM than other levels of vegetable and fruit consumption, respectively. SN - 1590-3729 UR - https://www.unboundmedicine.com/medline/citation/25456152/Fruit_and_vegetable_consumption_and_risk_of_type_2_diabetes_mellitus:_a_dose_response_meta_analysis_of_prospective_cohort_studies_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0939-4753(14)00312-3 DB - PRIME DP - Unbound Medicine ER -