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Contact urticaria on eczematous skin by kiwifruit allergy. In vivo component-resolved diagnosis.
Allergol Immunopathol (Madr) 2015 Sep-Oct; 43(5):474-6AI

Abstract

BACKGROUND

Kiwifruit allergy has been responsible for a variety of clinical manifestations, ranging from mild reactions, such as localised oral symptoms, to severe systemic symptoms, such as anaphylaxis. No cases of isolated contact urticaria (ICU) due to IgE-mediated allergy to kiwifruit have been reported in the literature so far. Here we describe the first three cases of ICU due to kiwi and we hypothesise about a kiwifruit allergen not described yet.

METHODS

Using the available in vivo allergy tests, we performed a component-resolved diagnosis to detect the allergen involved. All the patients underwent prick-by-prick with raw and boiled kiwi pulp and latex glove, skin prick test with commercial extracts of kiwifruit, birch, latex, palm profilin and peach lipid transfer protein, rub test with raw and boiled kiwi and oral food challenges with the raw fruit.

RESULTS

We found that, in our patients, the kiwifruit allergen responsible for ICU is thermolabile, gastrosensitive, and it does not show any of the most common kiwi-attributed cross-reactivity (latex, birch, profiling and lipid transfer protein). None of the 13 kiwifruit allergens already known shows all these features.

CONCLUSIONS

Kiwifruit allergy can also occur with ICU, probably due to a native protein that is not yet identified. In this case the elimination diet is not required.

Authors+Show Affiliations

Department of Pediatrics, Agostino Gemelli Hospital, Catholic University of Sacred Heart, Rome, Italy. Electronic address: smicelisopo@rm.unicatt.it.Department of Pediatrics, Agostino Gemelli Hospital, Catholic University of Sacred Heart, Rome, Italy.Department of Pediatrics, Agostino Gemelli Hospital, Catholic University of Sacred Heart, Rome, Italy.

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

25456531

Citation

Miceli Sopo, Stefano, et al. "Contact Urticaria On Eczematous Skin By Kiwifruit Allergy. in Vivo Component-resolved Diagnosis." Allergologia Et Immunopathologia, vol. 43, no. 5, 2015, pp. 474-6.
Miceli Sopo S, Fantacci C, Sani I. Contact urticaria on eczematous skin by kiwifruit allergy. In vivo component-resolved diagnosis. Allergol Immunopathol (Madr). 2015;43(5):474-6.
Miceli Sopo, S., Fantacci, C., & Sani, I. (2015). Contact urticaria on eczematous skin by kiwifruit allergy. In vivo component-resolved diagnosis. Allergologia Et Immunopathologia, 43(5), pp. 474-6. doi:10.1016/j.aller.2014.07.006.
Miceli Sopo S, Fantacci C, Sani I. Contact Urticaria On Eczematous Skin By Kiwifruit Allergy. in Vivo Component-resolved Diagnosis. Allergol Immunopathol (Madr). 2015;43(5):474-6. PubMed PMID: 25456531.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Contact urticaria on eczematous skin by kiwifruit allergy. In vivo component-resolved diagnosis. AU - Miceli Sopo,Stefano, AU - Fantacci,Claudia, AU - Sani,Ilaria, Y1 - 2014/11/11/ PY - 2014/04/15/received PY - 2014/07/22/revised PY - 2014/07/31/accepted PY - 2014/12/3/entrez PY - 2014/12/3/pubmed PY - 2016/6/9/medline KW - Contact urticaria KW - Food allergy KW - Kiwi fruit SP - 474 EP - 6 JF - Allergologia et immunopathologia JO - Allergol Immunopathol (Madr) VL - 43 IS - 5 N2 - BACKGROUND: Kiwifruit allergy has been responsible for a variety of clinical manifestations, ranging from mild reactions, such as localised oral symptoms, to severe systemic symptoms, such as anaphylaxis. No cases of isolated contact urticaria (ICU) due to IgE-mediated allergy to kiwifruit have been reported in the literature so far. Here we describe the first three cases of ICU due to kiwi and we hypothesise about a kiwifruit allergen not described yet. METHODS: Using the available in vivo allergy tests, we performed a component-resolved diagnosis to detect the allergen involved. All the patients underwent prick-by-prick with raw and boiled kiwi pulp and latex glove, skin prick test with commercial extracts of kiwifruit, birch, latex, palm profilin and peach lipid transfer protein, rub test with raw and boiled kiwi and oral food challenges with the raw fruit. RESULTS: We found that, in our patients, the kiwifruit allergen responsible for ICU is thermolabile, gastrosensitive, and it does not show any of the most common kiwi-attributed cross-reactivity (latex, birch, profiling and lipid transfer protein). None of the 13 kiwifruit allergens already known shows all these features. CONCLUSIONS: Kiwifruit allergy can also occur with ICU, probably due to a native protein that is not yet identified. In this case the elimination diet is not required. SN - 1578-1267 UR - https://www.unboundmedicine.com/medline/citation/25456531/Contact_urticaria_on_eczematous_skin_by_kiwifruit_allergy__In_vivo_component_resolved_diagnosis_ L2 - http://www.elsevier.es/en/linksolver/ft/pii/S0301-0546(14)00143-8 DB - PRIME DP - Unbound Medicine ER -