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Update on diabetes classification.
Med Clin North Am 2015; 99(1):1-16MC

Abstract

This article highlights the difficulties in creating a definitive classification of diabetes mellitus in the absence of a complete understanding of the pathogenesis of the major forms. This brief review shows the evolving nature of the classification of diabetes mellitus. No classification scheme is ideal, and all have some overlap and inconsistencies. The only diabetes in which it is possible to accurately diagnose by DNA sequencing, monogenic diabetes, remains undiagnosed in more than 90% of the individuals who have diabetes caused by one of the known gene mutations. The point of classification, or taxonomy, of disease, should be to give insight into both pathogenesis and treatment. It remains a source of frustration that all schemes of diabetes mellitus continue to fall short of this goal.

Authors+Show Affiliations

Department of Medicine, Section of Endocrinology, Diabetes and Metabolism, The University of Chicago, 5841 South Maryland Avenue, MC 1027, Chicago, IL 60637, USA. Electronic address: cthomas5@bsd.uchicago.edu.Department of Medicine, Section of Endocrinology, Diabetes and Metabolism, The University of Chicago, 5841 South Maryland Avenue, MC 1027, Chicago, IL 60637, USA; Department of Pediatrics, Section of Endocrinology, Diabetes and Metabolism, The University of Chicago, 900 East 57th Street, Chicago, IL 60637, USA.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

25456640

Citation

Thomas, Celeste C., and Louis H. Philipson. "Update On Diabetes Classification." The Medical Clinics of North America, vol. 99, no. 1, 2015, pp. 1-16.
Thomas CC, Philipson LH. Update on diabetes classification. Med Clin North Am. 2015;99(1):1-16.
Thomas, C. C., & Philipson, L. H. (2015). Update on diabetes classification. The Medical Clinics of North America, 99(1), pp. 1-16. doi:10.1016/j.mcna.2014.08.015.
Thomas CC, Philipson LH. Update On Diabetes Classification. Med Clin North Am. 2015;99(1):1-16. PubMed PMID: 25456640.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Update on diabetes classification. AU - Thomas,Celeste C, AU - Philipson,Louis H, Y1 - 2014/11/22/ PY - 2014/12/3/entrez PY - 2014/12/3/pubmed PY - 2015/4/11/medline KW - Classification of diabetes mellitus KW - Gestational diabetes mellitus KW - Latent autoimmune diabetes of adults KW - Maturity-onset diabetes of the young KW - Monogenic diabetes KW - Neonatal diabetes KW - Secondary diabetes KW - Type 1 and Type 2 diabetes mellitus SP - 1 EP - 16 JF - The Medical clinics of North America JO - Med. Clin. North Am. VL - 99 IS - 1 N2 - This article highlights the difficulties in creating a definitive classification of diabetes mellitus in the absence of a complete understanding of the pathogenesis of the major forms. This brief review shows the evolving nature of the classification of diabetes mellitus. No classification scheme is ideal, and all have some overlap and inconsistencies. The only diabetes in which it is possible to accurately diagnose by DNA sequencing, monogenic diabetes, remains undiagnosed in more than 90% of the individuals who have diabetes caused by one of the known gene mutations. The point of classification, or taxonomy, of disease, should be to give insight into both pathogenesis and treatment. It remains a source of frustration that all schemes of diabetes mellitus continue to fall short of this goal. SN - 1557-9859 UR - https://www.unboundmedicine.com/medline/citation/25456640/Update_on_diabetes_classification_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0025-7125(14)00141-2 DB - PRIME DP - Unbound Medicine ER -