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Leisure activities, apolipoprotein E e4 status, and the risk of dementia.

Abstract

BACKGROUND/PURPOSE

Leisure activities have been associated with a decreased risk of dementia. However, to date, no study has explored how apolipoprotein E (ApoE) e4 status or vascular risk factors modified the association between leisure activities and dementia risks.

METHODS

This case-control study recruited patients (age ≥ 60 years) with Alzheimer's disease (AD; n = 292) and vascular dementia (VaD; n = 144) and healthy controls (n = 506) from three teaching hospitals in Taiwan between 2007 and 2010. Information on patient's leisure activities were obtained through a questionnaire. Conditional logistic regression models were used to assess the association of leisure activities and ApoE e4 status with the risk of dementia.

RESULTS

High-frequency physical activity was associated with a decreased risk of AD [adjusted odds ratio (AOR) = 0.45], and the results become more evident among ApoE e4 carriers with AD (AOR = 0.30) and VaD (AOR = 0.26). Similar findings were observed for cognitive (AOR = 0.42) and social activities (AOR = 0.55) for AD. High-frequency physical, cognitive, and social activities were associated with a decreased risk of VaD (AOR = 0.29-0.60). Physical and social activities significantly interacted with each other on the risk of VaD (pinteraction = 0.04).

CONCLUSION

Physical activity consistently protects against AD and VaD. Significant interactions were identified across different types of leisure activities in lowering dementia risk.

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  • Authors+Show Affiliations

    ,

    Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.

    ,

    Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan; Department of Family Medicine, Taiwan Adventist Hospital, Taipei, Taiwan.

    ,

    Department of Geriatrics and Gerontology, National Taiwan University Hospital, Taipei, Taiwan.

    ,

    Institute of Statistical Science, Academia Sinica, Taipei, Taiwan.

    ,

    Institute of Health Policy and Management, College of Public Health, National Taiwan University, Taipei, Taiwan.

    ,

    Department of Neurology, National Taiwan University Hospital, Taipei, Taiwan.

    ,

    Department of Neurology, En Chu Kong Hospital, Taipei, Taiwan.

    ,

    Department of Laboratory Medicine, En Chu Kong Hospital, Taipei, Taiwan.

    ,

    School of Medicine, Fu-Jen Catholic University, Taipei, Taiwan; Center of Neurological Medicine, Cardinal Tien Hospital, Taipei, Taiwan.

    ,

    Department of Laboratory Medicine, Cardinal Tien Hospital, Taipei, Taiwan.

    Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan; Department of Public Health, College of Public Health, National Taiwan University, Taipei, Taiwan; Research Center for Genes, Environment, and Human Health, College of Public Health, National Taiwan University, Taipei, Taiwan. Electronic address: karenchen@ntu.edu.tw.

    Source

    MeSH

    Aged
    Aged, 80 and over
    Alzheimer Disease
    Apolipoprotein E4
    Case-Control Studies
    Female
    Genetic Markers
    Heterozygote
    Humans
    Leisure Activities
    Logistic Models
    Male
    Motor Activity
    Odds Ratio
    Risk Factors
    Surveys and Questionnaires
    Taiwan

    Pub Type(s)

    Journal Article
    Multicenter Study
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    25457293

    Citation

    Yang, Sheng-Ying, et al. "Leisure Activities, Apolipoprotein E E4 Status, and the Risk of Dementia." Journal of the Formosan Medical Association = Taiwan Yi Zhi, vol. 114, no. 12, 2015, pp. 1216-24.
    Yang SY, Weng PH, Chen JH, et al. Leisure activities, apolipoprotein E e4 status, and the risk of dementia. J Formos Med Assoc. 2015;114(12):1216-24.
    Yang, S. Y., Weng, P. H., Chen, J. H., Chiou, J. M., Lew-Ting, C. Y., Chen, T. F., ... Chen, Y. C. (2015). Leisure activities, apolipoprotein E e4 status, and the risk of dementia. Journal of the Formosan Medical Association = Taiwan Yi Zhi, 114(12), pp. 1216-24. doi:10.1016/j.jfma.2014.09.006.
    Yang SY, et al. Leisure Activities, Apolipoprotein E E4 Status, and the Risk of Dementia. J Formos Med Assoc. 2015;114(12):1216-24. PubMed PMID: 25457293.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Leisure activities, apolipoprotein E e4 status, and the risk of dementia. AU - Yang,Sheng-Ying, AU - Weng,Pei-Hsuan, AU - Chen,Jen-Hau, AU - Chiou,Jeng-Min, AU - Lew-Ting,Chih-Yin, AU - Chen,Ta-Fu, AU - Sun,Yu, AU - Wen,Li-Li, AU - Yip,Ping-Keung, AU - Chu,Yi-Min, AU - Chen,Yen-Ching, Y1 - 2014/11/04/ PY - 2013/11/22/received PY - 2014/09/25/revised PY - 2014/09/26/accepted PY - 2014/12/3/entrez PY - 2014/12/3/pubmed PY - 2016/12/15/medline KW - Alzheimer's disease KW - apolipoprotein E KW - dementia KW - leisure activities KW - vascular SP - 1216 EP - 24 JF - Journal of the Formosan Medical Association = Taiwan yi zhi JO - J. Formos. Med. Assoc. VL - 114 IS - 12 N2 - BACKGROUND/PURPOSE: Leisure activities have been associated with a decreased risk of dementia. However, to date, no study has explored how apolipoprotein E (ApoE) e4 status or vascular risk factors modified the association between leisure activities and dementia risks. METHODS: This case-control study recruited patients (age ≥ 60 years) with Alzheimer's disease (AD; n = 292) and vascular dementia (VaD; n = 144) and healthy controls (n = 506) from three teaching hospitals in Taiwan between 2007 and 2010. Information on patient's leisure activities were obtained through a questionnaire. Conditional logistic regression models were used to assess the association of leisure activities and ApoE e4 status with the risk of dementia. RESULTS: High-frequency physical activity was associated with a decreased risk of AD [adjusted odds ratio (AOR) = 0.45], and the results become more evident among ApoE e4 carriers with AD (AOR = 0.30) and VaD (AOR = 0.26). Similar findings were observed for cognitive (AOR = 0.42) and social activities (AOR = 0.55) for AD. High-frequency physical, cognitive, and social activities were associated with a decreased risk of VaD (AOR = 0.29-0.60). Physical and social activities significantly interacted with each other on the risk of VaD (pinteraction = 0.04). CONCLUSION: Physical activity consistently protects against AD and VaD. Significant interactions were identified across different types of leisure activities in lowering dementia risk. SN - 0929-6646 UR - https://www.unboundmedicine.com/medline/citation/25457293/Leisure_activities_apolipoprotein_E_e4_status_and_the_risk_of_dementia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0929-6646(14)00269-1 DB - PRIME DP - Unbound Medicine ER -