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Quinolone and indole alkaloids from the fruits of Euodia rutaecarpa and their cytotoxicity against two human cancer cell lines.
Phytochemistry. 2015 Jan; 109:133-9.P

Abstract

Four quinolone alkaloids (1-4) and three indole alkaloids (20-22), together with 30 known alkaloids (5-19, 23-37), were isolated from the fruits of Euodia rutaecarpa. Their structures were established by spectroscopic analyses. The in vitro cytotoxic activities of these alkaloids against leukaemia HL-60 and prostate cancer PC-3 cell lines were evaluated.

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Authors+Show Affiliations

Zhao N
Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, PR China; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, PR China.
Li ZL
Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, PR China; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, PR China. Electronic address: lzl1030@hotmail.com.
Li DH
Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, PR China; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, PR China.
Sun YT
Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, PR China; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, PR China.
Shan DT
Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, PR China; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, PR China.
Bai J
Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, PR China; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, PR China.
Pei YH
Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, PR China; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, PR China.
Jing YK
Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA.
Hua HM
Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, PR China; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, PR China. Electronic address: huimhua@163.com.

MeSH

Antineoplastic Agents, PhytogenicEvodiaFruitHL-60 CellsHumansIndole AlkaloidsMaleMolecular StructurePlant ExtractsProstatic NeoplasmsQuinolones

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25457491

Citation

Zhao, Nan, et al. "Quinolone and Indole Alkaloids From the Fruits of Euodia Rutaecarpa and Their Cytotoxicity Against Two Human Cancer Cell Lines." Phytochemistry, vol. 109, 2015, pp. 133-9.
Zhao N, Li ZL, Li DH, et al. Quinolone and indole alkaloids from the fruits of Euodia rutaecarpa and their cytotoxicity against two human cancer cell lines. Phytochemistry. 2015;109:133-9.
Zhao, N., Li, Z. L., Li, D. H., Sun, Y. T., Shan, D. T., Bai, J., Pei, Y. H., Jing, Y. K., & Hua, H. M. (2015). Quinolone and indole alkaloids from the fruits of Euodia rutaecarpa and their cytotoxicity against two human cancer cell lines. Phytochemistry, 109, 133-9. https://doi.org/10.1016/j.phytochem.2014.10.020
Zhao N, et al. Quinolone and Indole Alkaloids From the Fruits of Euodia Rutaecarpa and Their Cytotoxicity Against Two Human Cancer Cell Lines. Phytochemistry. 2015;109:133-9. PubMed PMID: 25457491.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Quinolone and indole alkaloids from the fruits of Euodia rutaecarpa and their cytotoxicity against two human cancer cell lines. AU - Zhao,Nan, AU - Li,Zhan-Lin, AU - Li,Da-Hong, AU - Sun,Ya-Ting, AU - Shan,Dong-Ting, AU - Bai,Jiao, AU - Pei,Yue-Hu, AU - Jing,Yong-Kui, AU - Hua,Hui-Ming, Y1 - 2014/11/22/ PY - 2014/05/16/received PY - 2014/07/11/revised PY - 2014/10/16/accepted PY - 2014/12/3/entrez PY - 2014/12/3/pubmed PY - 2015/6/3/medline KW - Euodia rutaecarpa KW - Growth inhibitory activity KW - Indole alkaloid KW - Quinolone alkaloid KW - Rutaceae SP - 133 EP - 9 JF - Phytochemistry JO - Phytochemistry VL - 109 N2 - Four quinolone alkaloids (1-4) and three indole alkaloids (20-22), together with 30 known alkaloids (5-19, 23-37), were isolated from the fruits of Euodia rutaecarpa. Their structures were established by spectroscopic analyses. The in vitro cytotoxic activities of these alkaloids against leukaemia HL-60 and prostate cancer PC-3 cell lines were evaluated. SN - 1873-3700 UR - https://www.unboundmedicine.com/medline/citation/25457491/Quinolone_and_indole_alkaloids_from_the_fruits_of_Euodia_rutaecarpa_and_their_cytotoxicity_against_two_human_cancer_cell_lines_ DB - PRIME DP - Unbound Medicine ER -