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Brainstem auditory evoked potentials in children with lead exposure.
Braz J Otorhinolaryngol. 2015 Jan-Feb; 81(1):37-43.BJ

Abstract

INTRODUCTION

Earlier studies have demonstrated an auditory effect of lead exposure in children, but information on the effects of low chronic exposures needs to be further elucidated.

OBJECTIVE

To investigate the effect of low chronic exposures of the auditory system in children with a history of low blood lead levels, using an auditory electrophysiological test.

METHODS

Contemporary cross-sectional cohort. Study participants underwent tympanometry, pure tone and speech audiometry, transient evoked otoacoustic emissions, and brainstem auditory evoked potentials, with blood lead monitoring over a period of 35.5 months. The study included 130 children, with ages ranging from 18 months to 14 years, 5 months (mean age 6 years, 8 months ± 3 years, 2 months).

RESULTS

The mean time-integrated cumulative blood lead index was 12 μg/dL (SD ± 5.7, range: 2.433). All participants had hearing thresholds equal to or below 20 dBHL and normal amplitudes of transient evoked otoacoustic emissions. No association was found between the absolute latencies of waves I, III, and V, the interpeak latencies I-III, III-V, and I-V, and the cumulative lead values.

CONCLUSION

No evidence of toxic effects from chronic low lead exposures was observed on the auditory function of children living in a lead contaminated area.

Authors+Show Affiliations

Department of Speech Therapy and Audiology, Faculdade de Odontologia de Bauru, Universidade de São Paulo (FOB-USP), Bauru, SP, Brazil.National Institute for Occupational Safety and Health (NIOSH), Division of Applied Research and Technology, Cincinnati, OH, United States.Department of Speech Therapy and Audiology, Faculdade de Odontologia de Bauru, Universidade de São Paulo (FOB-USP), Bauru, SP, Brazil.Department of Speech Therapy and Audiology, Faculdade de Odontologia de Bauru, Universidade de São Paulo (FOB-USP), Bauru, SP, Brazil.Department of Speech Therapy and Audiology, Faculdade de Odontologia de Bauru, Universidade de São Paulo (FOB-USP), Bauru, SP, Brazil. Electronic address: lilianjacob@fob.usp.br.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25458254

Citation

Alvarenga, Katia de Freitas, et al. "Brainstem Auditory Evoked Potentials in Children With Lead Exposure." Brazilian Journal of Otorhinolaryngology, vol. 81, no. 1, 2015, pp. 37-43.
Alvarenga Kde F, Morata TC, Lopes AC, et al. Brainstem auditory evoked potentials in children with lead exposure. Braz J Otorhinolaryngol. 2015;81(1):37-43.
Alvarenga, K. d. e. . F., Morata, T. C., Lopes, A. C., Feniman, M. R., & Corteletti, L. C. (2015). Brainstem auditory evoked potentials in children with lead exposure. Brazilian Journal of Otorhinolaryngology, 81(1), 37-43. https://doi.org/10.1016/j.bjorl.2013.12.001
Alvarenga Kde F, et al. Brainstem Auditory Evoked Potentials in Children With Lead Exposure. Braz J Otorhinolaryngol. 2015 Jan-Feb;81(1):37-43. PubMed PMID: 25458254.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Brainstem auditory evoked potentials in children with lead exposure. AU - Alvarenga,Katia de Freitas, AU - Morata,Thais Catalani, AU - Lopes,Andrea Cintra, AU - Feniman,Mariza Ribeiro, AU - Corteletti,Lilian Cassia Bornia Jacob, Y1 - 2014/10/18/ PY - 2013/09/11/received PY - 2013/12/23/accepted PY - 2014/12/3/entrez PY - 2014/12/3/pubmed PY - 2016/5/18/medline KW - Audiometria de tons puros KW - Brainstem auditory evoked potentials KW - Intoxicação por chumbo KW - Lead poisoning KW - Potenciais evocados auditivos do tronco encefálico KW - Pure-tone audiometry KW - Toxicidade KW - Toxicity SP - 37 EP - 43 JF - Brazilian journal of otorhinolaryngology JO - Braz J Otorhinolaryngol VL - 81 IS - 1 N2 - INTRODUCTION: Earlier studies have demonstrated an auditory effect of lead exposure in children, but information on the effects of low chronic exposures needs to be further elucidated. OBJECTIVE: To investigate the effect of low chronic exposures of the auditory system in children with a history of low blood lead levels, using an auditory electrophysiological test. METHODS: Contemporary cross-sectional cohort. Study participants underwent tympanometry, pure tone and speech audiometry, transient evoked otoacoustic emissions, and brainstem auditory evoked potentials, with blood lead monitoring over a period of 35.5 months. The study included 130 children, with ages ranging from 18 months to 14 years, 5 months (mean age 6 years, 8 months ± 3 years, 2 months). RESULTS: The mean time-integrated cumulative blood lead index was 12 μg/dL (SD ± 5.7, range: 2.433). All participants had hearing thresholds equal to or below 20 dBHL and normal amplitudes of transient evoked otoacoustic emissions. No association was found between the absolute latencies of waves I, III, and V, the interpeak latencies I-III, III-V, and I-V, and the cumulative lead values. CONCLUSION: No evidence of toxic effects from chronic low lead exposures was observed on the auditory function of children living in a lead contaminated area. SN - 1808-8686 UR - https://www.unboundmedicine.com/medline/citation/25458254/Brainstem_auditory_evoked_potentials_in_children_with_lead_exposure_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1808-8694(14)00124-4 DB - PRIME DP - Unbound Medicine ER -