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A pathological study of the association between Lewy body disease and Alzheimer's disease.
J Neurol Neurosurg Psychiatry. 1989 Jun; 52(6):701-8.JN

Abstract

The possibility of an association between Parkinson's disease and Alzheimer's disease has been examined by studying the age-specific prevalence of Lewy bodies in the substantia nigra in a group of 273 control cases without Parkinson's disease and 121 cases of Alzheimer's disease. The substantia nigra was also studied in 14 cases of Down's syndrome, 13 of which had cortical Alzheimer pathology. Twelve (7.8%) of the controls aged over 60 years showed nigral Lewy bodies. There was mild nerve cell degeneration and/or an extranigral distribution of Lewy bodies, suggestive of presymptomatic Parkinson's disease. Twenty five (22.5%) of the Alzheimer's disease cases over 60 years showed Lewy bodies, but only 14 (14.0%) of these had mild nigral cell loss consistent with presymptomatic Parkinson's disease. No case of Down's syndrome had Lewy bodies. Counts of tangles and plaques in hippocampus, frontal and temporal cortex were lower in cases of Alzheimer's disease with Lewy bodies compared with those without, but cortical choline acetyltransferase (ChAT) activities were similar. This suggests that Lewy body degeneration in the nucleus basalis of Meynert contributes to the deficit of cortical ChAT, but not to the cortical Alzheimer pathology. The relatively small difference in the prevalence of Lewy bodies between controls and Alzheimer's disease could be explained by the additive effects of Lewy body and tangle pathology causing dementia, rather than a greater than chance association between Parkinson's disease and Alzheimer's disease.

Authors+Show Affiliations

Department of Neuropathology, National Hospital for Nervous Diseases, Maida Vale, London, UK.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2545826

Citation

Gibb, W R., et al. "A Pathological Study of the Association Between Lewy Body Disease and Alzheimer's Disease." Journal of Neurology, Neurosurgery, and Psychiatry, vol. 52, no. 6, 1989, pp. 701-8.
Gibb WR, Mountjoy CQ, Mann DM, et al. A pathological study of the association between Lewy body disease and Alzheimer's disease. J Neurol Neurosurg Psychiatry. 1989;52(6):701-8.
Gibb, W. R., Mountjoy, C. Q., Mann, D. M., & Lees, A. J. (1989). A pathological study of the association between Lewy body disease and Alzheimer's disease. Journal of Neurology, Neurosurgery, and Psychiatry, 52(6), 701-8.
Gibb WR, et al. A Pathological Study of the Association Between Lewy Body Disease and Alzheimer's Disease. J Neurol Neurosurg Psychiatry. 1989;52(6):701-8. PubMed PMID: 2545826.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A pathological study of the association between Lewy body disease and Alzheimer's disease. AU - Gibb,W R, AU - Mountjoy,C Q, AU - Mann,D M, AU - Lees,A J, PY - 1989/6/1/pubmed PY - 1989/6/1/medline PY - 1989/6/1/entrez SP - 701 EP - 8 JF - Journal of neurology, neurosurgery, and psychiatry JO - J Neurol Neurosurg Psychiatry VL - 52 IS - 6 N2 - The possibility of an association between Parkinson's disease and Alzheimer's disease has been examined by studying the age-specific prevalence of Lewy bodies in the substantia nigra in a group of 273 control cases without Parkinson's disease and 121 cases of Alzheimer's disease. The substantia nigra was also studied in 14 cases of Down's syndrome, 13 of which had cortical Alzheimer pathology. Twelve (7.8%) of the controls aged over 60 years showed nigral Lewy bodies. There was mild nerve cell degeneration and/or an extranigral distribution of Lewy bodies, suggestive of presymptomatic Parkinson's disease. Twenty five (22.5%) of the Alzheimer's disease cases over 60 years showed Lewy bodies, but only 14 (14.0%) of these had mild nigral cell loss consistent with presymptomatic Parkinson's disease. No case of Down's syndrome had Lewy bodies. Counts of tangles and plaques in hippocampus, frontal and temporal cortex were lower in cases of Alzheimer's disease with Lewy bodies compared with those without, but cortical choline acetyltransferase (ChAT) activities were similar. This suggests that Lewy body degeneration in the nucleus basalis of Meynert contributes to the deficit of cortical ChAT, but not to the cortical Alzheimer pathology. The relatively small difference in the prevalence of Lewy bodies between controls and Alzheimer's disease could be explained by the additive effects of Lewy body and tangle pathology causing dementia, rather than a greater than chance association between Parkinson's disease and Alzheimer's disease. SN - 0022-3050 UR - https://www.unboundmedicine.com/medline/citation/2545826/A_pathological_study_of_the_association_between_Lewy_body_disease_and_Alzheimer's_disease_ L2 - https://jnnp.bmj.com/lookup/pmidlookup?view=long&pmid=2545826 DB - PRIME DP - Unbound Medicine ER -