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Optimizing the diagnosis of food allergy.
Immunol Allergy Clin North Am. 2015 Feb; 35(1):61-76.IA

Abstract

Accurately diagnosing a patient with a possible food allergy is important to avoid unnecessary dietary restrictions and prevent life-threatening reactions. Routine testing modalities have limited accuracy, and an oral food challenge is often required to make a definitive diagnosis. Given that they are labor intensive and risk inducing an allergic reaction, several alternative diagnostic modalities have been investigated. Testing for IgE antibodies to particular protein components in foods has shown promise to improve diagnostics and has entered clinical practice. Additional modalities show potential, including epitope binding, T-cell studies, and basophil activation.

Authors+Show Affiliations

Department of Pediatric Allergy and Immunology, Jaffe Food Allergy Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, Box 1198, New York, NY 10029, USA. Electronic address: jacob.kattan@mssm.edu.Department of Pediatric Allergy and Immunology, Jaffe Food Allergy Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, Box 1198, New York, NY 10029, USA.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

25459577

Citation

Kattan, Jacob D., and Scott H. Sicherer. "Optimizing the Diagnosis of Food Allergy." Immunology and Allergy Clinics of North America, vol. 35, no. 1, 2015, pp. 61-76.
Kattan JD, Sicherer SH. Optimizing the diagnosis of food allergy. Immunol Allergy Clin North Am. 2015;35(1):61-76.
Kattan, J. D., & Sicherer, S. H. (2015). Optimizing the diagnosis of food allergy. Immunology and Allergy Clinics of North America, 35(1), 61-76. https://doi.org/10.1016/j.iac.2014.09.009
Kattan JD, Sicherer SH. Optimizing the Diagnosis of Food Allergy. Immunol Allergy Clin North Am. 2015;35(1):61-76. PubMed PMID: 25459577.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Optimizing the diagnosis of food allergy. AU - Kattan,Jacob D, AU - Sicherer,Scott H, Y1 - 2014/11/21/ PY - 2014/12/3/entrez PY - 2014/12/3/pubmed PY - 2015/8/1/medline KW - Basophil activation KW - Component-resolved diagnostics KW - Diagnosis KW - Epitope KW - Food allergy KW - Food-specific IgE KW - Oral food challenge KW - Skin prick testing SP - 61 EP - 76 JF - Immunology and allergy clinics of North America JO - Immunol Allergy Clin North Am VL - 35 IS - 1 N2 - Accurately diagnosing a patient with a possible food allergy is important to avoid unnecessary dietary restrictions and prevent life-threatening reactions. Routine testing modalities have limited accuracy, and an oral food challenge is often required to make a definitive diagnosis. Given that they are labor intensive and risk inducing an allergic reaction, several alternative diagnostic modalities have been investigated. Testing for IgE antibodies to particular protein components in foods has shown promise to improve diagnostics and has entered clinical practice. Additional modalities show potential, including epitope binding, T-cell studies, and basophil activation. SN - 1557-8607 UR - https://www.unboundmedicine.com/medline/citation/25459577/Optimizing_the_diagnosis_of_food_allergy_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0889-8561(14)00109-X DB - PRIME DP - Unbound Medicine ER -