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Coffee consumption and risk of gastric cancer: an updated meta-analysis.
Clin Res Hepatol Gastroenterol. 2015 Apr; 39(2):245-53.CR

Abstract

OBJECTIVES

The aim of this study was to perform an updated review to evaluate the effect of coffee consumption on the risk of gastric cancer.

METHODS

We searched the PubMed and Embase database up to October 14th, 2013. Risk ratio (RR) and corresponding 95% confidence intervals (CIs) for the risk of gastric cancer were used as effect sizes. Overall effect sizes were derived using a fixed-effects model or a random-effects model when appropriate. Then in subgroup analyses, the data were reanalyzed, which were stratified by gender, area and follow-up time.

RESULTS

A total of 8 separate studies, including 312,993 volunteers (among them 1429 were diagnosed with gastric cancer in 10-18 years' follow-up), were considered in the meta-analysis. The overall estimate of coffee consumption on the risk of gastric cancer showed a pooled RR of 1.24 (95% CI: 1.03-1.49; P=0.026). In subgroup analyses, the pooled RR of gastric cancer was 1.36 (95% CI: 1.06-1.75) for USA volunteers and 1.29 (95% CI: 1.05-1.59) for people with more than 15-year follow-up time. The sensitivity analysis proved the stability and credibility of our results, and there was no significant bias (Begg's test P=0.640, Egger's test P=0.600) among the studies.

CONCLUSIONS

It indicated that coffee consumption was associated with the development of gastric cancer. More coffee drinking could result in the increased risk of gastric cancer.

Authors+Show Affiliations

Department of General Surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, 200127 Shanghai, China.Department of General Surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, 200127 Shanghai, China.Department of General Surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, 200127 Shanghai, China. Electronic address: HuiCaohc@163.com.

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

25459992

Citation

Shen, Zhiyong, et al. "Coffee Consumption and Risk of Gastric Cancer: an Updated Meta-analysis." Clinics and Research in Hepatology and Gastroenterology, vol. 39, no. 2, 2015, pp. 245-53.
Shen Z, Liu H, Cao H. Coffee consumption and risk of gastric cancer: an updated meta-analysis. Clin Res Hepatol Gastroenterol. 2015;39(2):245-53.
Shen, Z., Liu, H., & Cao, H. (2015). Coffee consumption and risk of gastric cancer: an updated meta-analysis. Clinics and Research in Hepatology and Gastroenterology, 39(2), 245-53. https://doi.org/10.1016/j.clinre.2014.09.005
Shen Z, Liu H, Cao H. Coffee Consumption and Risk of Gastric Cancer: an Updated Meta-analysis. Clin Res Hepatol Gastroenterol. 2015;39(2):245-53. PubMed PMID: 25459992.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Coffee consumption and risk of gastric cancer: an updated meta-analysis. AU - Shen,Zhiyong, AU - Liu,Hua, AU - Cao,Hui, Y1 - 2014/11/11/ PY - 2014/07/07/received PY - 2014/09/04/revised PY - 2014/09/17/accepted PY - 2014/12/3/entrez PY - 2014/12/3/pubmed PY - 2016/1/27/medline SP - 245 EP - 53 JF - Clinics and research in hepatology and gastroenterology JO - Clin Res Hepatol Gastroenterol VL - 39 IS - 2 N2 - OBJECTIVES: The aim of this study was to perform an updated review to evaluate the effect of coffee consumption on the risk of gastric cancer. METHODS: We searched the PubMed and Embase database up to October 14th, 2013. Risk ratio (RR) and corresponding 95% confidence intervals (CIs) for the risk of gastric cancer were used as effect sizes. Overall effect sizes were derived using a fixed-effects model or a random-effects model when appropriate. Then in subgroup analyses, the data were reanalyzed, which were stratified by gender, area and follow-up time. RESULTS: A total of 8 separate studies, including 312,993 volunteers (among them 1429 were diagnosed with gastric cancer in 10-18 years' follow-up), were considered in the meta-analysis. The overall estimate of coffee consumption on the risk of gastric cancer showed a pooled RR of 1.24 (95% CI: 1.03-1.49; P=0.026). In subgroup analyses, the pooled RR of gastric cancer was 1.36 (95% CI: 1.06-1.75) for USA volunteers and 1.29 (95% CI: 1.05-1.59) for people with more than 15-year follow-up time. The sensitivity analysis proved the stability and credibility of our results, and there was no significant bias (Begg's test P=0.640, Egger's test P=0.600) among the studies. CONCLUSIONS: It indicated that coffee consumption was associated with the development of gastric cancer. More coffee drinking could result in the increased risk of gastric cancer. SN - 2210-741X UR - https://www.unboundmedicine.com/medline/citation/25459992/Coffee_consumption_and_risk_of_gastric_cancer:_an_updated_meta_analysis_ DB - PRIME DP - Unbound Medicine ER -
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