Abstract
OBJECTIVES
The aim of this study was to perform an updated review to evaluate the effect of coffee consumption on the risk of gastric cancer.
METHODS
We searched the PubMed and Embase database up to October 14th, 2013. Risk ratio (RR) and corresponding 95% confidence intervals (CIs) for the risk of gastric cancer were used as effect sizes. Overall effect sizes were derived using a fixed-effects model or a random-effects model when appropriate. Then in subgroup analyses, the data were reanalyzed, which were stratified by gender, area and follow-up time.
RESULTS
A total of 8 separate studies, including 312,993 volunteers (among them 1429 were diagnosed with gastric cancer in 10-18 years' follow-up), were considered in the meta-analysis. The overall estimate of coffee consumption on the risk of gastric cancer showed a pooled RR of 1.24 (95% CI: 1.03-1.49; P=0.026). In subgroup analyses, the pooled RR of gastric cancer was 1.36 (95% CI: 1.06-1.75) for USA volunteers and 1.29 (95% CI: 1.05-1.59) for people with more than 15-year follow-up time. The sensitivity analysis proved the stability and credibility of our results, and there was no significant bias (Begg's test P=0.640, Egger's test P=0.600) among the studies.
CONCLUSIONS
It indicated that coffee consumption was associated with the development of gastric cancer. More coffee drinking could result in the increased risk of gastric cancer.
TY - JOUR
T1 - Coffee consumption and risk of gastric cancer: an updated meta-analysis.
AU - Shen,Zhiyong,
AU - Liu,Hua,
AU - Cao,Hui,
Y1 - 2014/11/11/
PY - 2014/07/07/received
PY - 2014/09/04/revised
PY - 2014/09/17/accepted
PY - 2014/12/3/entrez
PY - 2014/12/3/pubmed
PY - 2016/1/27/medline
SP - 245
EP - 53
JF - Clinics and research in hepatology and gastroenterology
JO - Clin Res Hepatol Gastroenterol
VL - 39
IS - 2
N2 - OBJECTIVES: The aim of this study was to perform an updated review to evaluate the effect of coffee consumption on the risk of gastric cancer. METHODS: We searched the PubMed and Embase database up to October 14th, 2013. Risk ratio (RR) and corresponding 95% confidence intervals (CIs) for the risk of gastric cancer were used as effect sizes. Overall effect sizes were derived using a fixed-effects model or a random-effects model when appropriate. Then in subgroup analyses, the data were reanalyzed, which were stratified by gender, area and follow-up time. RESULTS: A total of 8 separate studies, including 312,993 volunteers (among them 1429 were diagnosed with gastric cancer in 10-18 years' follow-up), were considered in the meta-analysis. The overall estimate of coffee consumption on the risk of gastric cancer showed a pooled RR of 1.24 (95% CI: 1.03-1.49; P=0.026). In subgroup analyses, the pooled RR of gastric cancer was 1.36 (95% CI: 1.06-1.75) for USA volunteers and 1.29 (95% CI: 1.05-1.59) for people with more than 15-year follow-up time. The sensitivity analysis proved the stability and credibility of our results, and there was no significant bias (Begg's test P=0.640, Egger's test P=0.600) among the studies. CONCLUSIONS: It indicated that coffee consumption was associated with the development of gastric cancer. More coffee drinking could result in the increased risk of gastric cancer.
SN - 2210-741X
UR - https://www.unboundmedicine.com/medline/citation/25459992/Coffee_consumption_and_risk_of_gastric_cancer:_an_updated_meta_analysis_
DB - PRIME
DP - Unbound Medicine
ER -
