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Protective glove use and hygiene habits modify the associations of specific pesticides with Parkinson's disease.
Environ Int. 2015 Feb; 75:144-50.EI

Abstract

Pesticides have been associated with Parkinson's disease (PD), and protective gloves and workplace hygiene can reduce pesticide exposure. We assessed whether use of gloves and workplace hygiene modified associations between pesticides and PD. The Farming and Movement Evaluation (FAME) study is a nested case-control study within the Agricultural Health Study. Use of protective gloves, other PPE, and hygiene practices were determined by questionnaire (69 cases and 237 controls were included). We considered interactions of gloves and hygiene with ever-use of pesticides for all pesticides with ≥5 exposed and unexposed cases and controls in each glove-use stratum (paraquat, permethrin, rotenone, and trifluralin). 61% of respondents consistently used protective gloves and 87% consistently used ≥2 hygiene practices. Protective glove use modified the associations of paraquat and permethrin with PD: neither pesticide was associated with PD among protective glove users, while both pesticides were associated with PD among non-users (paraquat OR 3.9 [95% CI 1.3, 11.7], interaction p=0.15; permethrin OR 4.3 [95% CI 1.2, 15.6] interaction p=0.05). Rotenone was associated with PD regardless of glove use. Trifluralin was associated with PD among participants who used <2 hygiene practices (OR 5.5 [95% CI 1.1, 27.1]) but was not associated with PD among participants who used 2 or more practices (interaction p=0.02). Although sample size was limited in the FAME study, protective glove use and hygiene practices appeared to be important modifiers of the association between pesticides and PD and may reduce risk of PD associated with certain pesticides.

Authors+Show Affiliations

University of North Carolina at Chapel Hill, Gillings School of Global Public Health, Department of Epidemiology, Chapel Hill, NC, United States. Electronic address: furlongm@med.unc.edu.San Francisco Veteran's Affairs Medical Center, Parkinson's Disease Research, Education and Clinical Center, San Francisco, CA, United States; The University of California at San Francisco School of Medicine, Department of Neurology, United States.The University of California at San Francisco School of Medicine, Department of Neurology, United States.The Parkinson's Institute and Clinical Center, Sunnyvale, CA, United States.National Cancer Institute, Occupational and Environmental Epidemiology Branch, United States.Favaloro University, Institute of Neuroscience, Buenos Aires, Argentina.The University of California at San Francisco School of Medicine, Department of Neurology, United States.North Carolina State University, Department of Biological Sciences, Raleigh, NC, United States.University of Lubeck, Department of Psychiatry, Lubeck, Germany.The University of California at San Francisco School of Medicine, Department of Neurology, United States.The Parkinson's Institute and Clinical Center, Sunnyvale, CA, United States.University of Toronto, Toronto, Ontario, Canada.San Francisco Veteran's Affairs Medical Center, Parkinson's Disease Research, Education and Clinical Center, San Francisco, CA, United States; The University of California at San Francisco School of Medicine, Department of Neurology, United States.Westat Inc., Durham, NC, United States.VA Pacific Islands Health Care System, Honolulu, HI, United States.National Institutes of Environmental Health Sciences, Biostatistics Branch, Research Triangle Park, NC, United States.National Institutes of Environmental Health Sciences, Epidemiology Branch, Research Triangle Park, NC, United States.National Institutes of Environmental Health Sciences, Epidemiology Branch, Research Triangle Park, NC, United States.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural

Language

eng

PubMed ID

25461423

Citation

Furlong, Melissa, et al. "Protective Glove Use and Hygiene Habits Modify the Associations of Specific Pesticides With Parkinson's Disease." Environment International, vol. 75, 2015, pp. 144-50.
Furlong M, Tanner CM, Goldman SM, et al. Protective glove use and hygiene habits modify the associations of specific pesticides with Parkinson's disease. Environ Int. 2015;75:144-50.
Furlong, M., Tanner, C. M., Goldman, S. M., Bhudhikanok, G. S., Blair, A., Chade, A., Comyns, K., Hoppin, J. A., Kasten, M., Korell, M., Langston, J. W., Marras, C., Meng, C., Richards, M., Ross, G. W., Umbach, D. M., Sandler, D. P., & Kamel, F. (2015). Protective glove use and hygiene habits modify the associations of specific pesticides with Parkinson's disease. Environment International, 75, 144-50. https://doi.org/10.1016/j.envint.2014.11.002
Furlong M, et al. Protective Glove Use and Hygiene Habits Modify the Associations of Specific Pesticides With Parkinson's Disease. Environ Int. 2015;75:144-50. PubMed PMID: 25461423.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protective glove use and hygiene habits modify the associations of specific pesticides with Parkinson's disease. AU - Furlong,Melissa, AU - Tanner,Caroline M, AU - Goldman,Samuel M, AU - Bhudhikanok,Grace S, AU - Blair,Aaron, AU - Chade,Anabel, AU - Comyns,Kathleen, AU - Hoppin,Jane A, AU - Kasten,Meike, AU - Korell,Monica, AU - Langston,J William, AU - Marras,Connie, AU - Meng,Cheryl, AU - Richards,Marie, AU - Ross,G Webster, AU - Umbach,David M, AU - Sandler,Dale P, AU - Kamel,Freya, Y1 - 2014/11/21/ PY - 2014/07/17/received PY - 2014/10/12/revised PY - 2014/11/06/accepted PY - 2014/12/3/entrez PY - 2014/12/3/pubmed PY - 2015/9/1/medline KW - Movement disorders KW - Neurodegenerative diseases KW - Parkinson's disease KW - Personal protective equipment KW - Pesticides SP - 144 EP - 50 JF - Environment international JO - Environ Int VL - 75 N2 - Pesticides have been associated with Parkinson's disease (PD), and protective gloves and workplace hygiene can reduce pesticide exposure. We assessed whether use of gloves and workplace hygiene modified associations between pesticides and PD. The Farming and Movement Evaluation (FAME) study is a nested case-control study within the Agricultural Health Study. Use of protective gloves, other PPE, and hygiene practices were determined by questionnaire (69 cases and 237 controls were included). We considered interactions of gloves and hygiene with ever-use of pesticides for all pesticides with ≥5 exposed and unexposed cases and controls in each glove-use stratum (paraquat, permethrin, rotenone, and trifluralin). 61% of respondents consistently used protective gloves and 87% consistently used ≥2 hygiene practices. Protective glove use modified the associations of paraquat and permethrin with PD: neither pesticide was associated with PD among protective glove users, while both pesticides were associated with PD among non-users (paraquat OR 3.9 [95% CI 1.3, 11.7], interaction p=0.15; permethrin OR 4.3 [95% CI 1.2, 15.6] interaction p=0.05). Rotenone was associated with PD regardless of glove use. Trifluralin was associated with PD among participants who used <2 hygiene practices (OR 5.5 [95% CI 1.1, 27.1]) but was not associated with PD among participants who used 2 or more practices (interaction p=0.02). Although sample size was limited in the FAME study, protective glove use and hygiene practices appeared to be important modifiers of the association between pesticides and PD and may reduce risk of PD associated with certain pesticides. SN - 1873-6750 UR - https://www.unboundmedicine.com/medline/citation/25461423/Protective_glove_use_and_hygiene_habits_modify_the_associations_of_specific_pesticides_with_Parkinson's_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0160-4120(14)00324-9 DB - PRIME DP - Unbound Medicine ER -