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Fruits, vegetables, and bladder cancer risk: a systematic review and meta-analysis.
Cancer Med 2015; 4(1):136-46CM

Abstract

Smoking is estimated to cause about half of all bladder cancer cases. Case-control studies have provided evidence of an inverse association between fruit and vegetable intake and bladder cancer risk. As part of the World Cancer Research/American Institute for Cancer Research Continuous Update Project, we conducted a systematic review and meta-analysis of prospective studies to assess the dose-response relationship between fruit and vegetables and incidence and mortality of bladder cancer. We searched PubMed up to December 2013 for relevant prospective studies. We conducted highest compared with lowest meta-analyses and dose-response meta-analyses using random effects models to estimate summary relative risks (RRs) and 95% confidence intervals (CIs), and used restricted cubic splines to examine possible nonlinear associations. Fifteen prospective studies were included in the review. The summary RR for an increase of 1 serving/day (80 g) were 0.97 (95% CI: 0.95-0.99) I(2) = 0%, eight studies for fruits and vegetables, 0.97 (95% CI: 0.94-1.00, I(2) = 10%, 10 studies) for vegetables and 0.98 (95% CI: 0.96-1.00, I(2) = 0%, 12 studies) for fruits. Results were similar in men and women and in current, former and nonsmokers. Amongst fruits and vegetables subgroups, for citrus fruits the summary RR for the highest compared with the lowest intake was 0.87 (95% CI: 0.76-0.99, I(2) = 0%, eight studies) and for cruciferous vegetables there was evidence of a nonlinear relationship (P = 0.001). The current evidence from cohort studies is not consistent with a role for fruits and vegetables in preventing bladder cancer.

Authors+Show Affiliations

Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Review
Systematic Review

Language

eng

PubMed ID

25461441

Citation

Vieira, Ana R., et al. "Fruits, Vegetables, and Bladder Cancer Risk: a Systematic Review and Meta-analysis." Cancer Medicine, vol. 4, no. 1, 2015, pp. 136-46.
Vieira AR, Vingeliene S, Chan DS, et al. Fruits, vegetables, and bladder cancer risk: a systematic review and meta-analysis. Cancer Med. 2015;4(1):136-46.
Vieira, A. R., Vingeliene, S., Chan, D. S., Aune, D., Abar, L., Navarro Rosenblatt, D., ... Norat, T. (2015). Fruits, vegetables, and bladder cancer risk: a systematic review and meta-analysis. Cancer Medicine, 4(1), pp. 136-46. doi:10.1002/cam4.327.
Vieira AR, et al. Fruits, Vegetables, and Bladder Cancer Risk: a Systematic Review and Meta-analysis. Cancer Med. 2015;4(1):136-46. PubMed PMID: 25461441.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fruits, vegetables, and bladder cancer risk: a systematic review and meta-analysis. AU - Vieira,Ana R, AU - Vingeliene,Snieguole, AU - Chan,Doris S M, AU - Aune,Dagfinn, AU - Abar,Leila, AU - Navarro Rosenblatt,Deborah, AU - Greenwood,Darren C, AU - Norat,Teresa, Y1 - 2014/12/02/ PY - 2014/06/10/received PY - 2014/07/22/revised PY - 2014/07/31/accepted PY - 2014/12/3/entrez PY - 2014/12/3/pubmed PY - 2015/9/17/medline KW - Bladder cancer KW - fruits KW - meta-analysis KW - systematic review KW - vegetables SP - 136 EP - 46 JF - Cancer medicine JO - Cancer Med VL - 4 IS - 1 N2 - Smoking is estimated to cause about half of all bladder cancer cases. Case-control studies have provided evidence of an inverse association between fruit and vegetable intake and bladder cancer risk. As part of the World Cancer Research/American Institute for Cancer Research Continuous Update Project, we conducted a systematic review and meta-analysis of prospective studies to assess the dose-response relationship between fruit and vegetables and incidence and mortality of bladder cancer. We searched PubMed up to December 2013 for relevant prospective studies. We conducted highest compared with lowest meta-analyses and dose-response meta-analyses using random effects models to estimate summary relative risks (RRs) and 95% confidence intervals (CIs), and used restricted cubic splines to examine possible nonlinear associations. Fifteen prospective studies were included in the review. The summary RR for an increase of 1 serving/day (80 g) were 0.97 (95% CI: 0.95-0.99) I(2) = 0%, eight studies for fruits and vegetables, 0.97 (95% CI: 0.94-1.00, I(2) = 10%, 10 studies) for vegetables and 0.98 (95% CI: 0.96-1.00, I(2) = 0%, 12 studies) for fruits. Results were similar in men and women and in current, former and nonsmokers. Amongst fruits and vegetables subgroups, for citrus fruits the summary RR for the highest compared with the lowest intake was 0.87 (95% CI: 0.76-0.99, I(2) = 0%, eight studies) and for cruciferous vegetables there was evidence of a nonlinear relationship (P = 0.001). The current evidence from cohort studies is not consistent with a role for fruits and vegetables in preventing bladder cancer. SN - 2045-7634 UR - https://www.unboundmedicine.com/medline/citation/25461441/Fruits_vegetables_and_bladder_cancer_risk:_a_systematic_review_and_meta_analysis_ L2 - https://doi.org/10.1002/cam4.327 DB - PRIME DP - Unbound Medicine ER -