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Impact of sulfidation on the bioavailability and toxicity of silver nanoparticles to Caenorhabditis elegans.
Environ Pollut. 2015 Jan; 196:239-46.EP

Abstract

Sulfidation is a major transformation product for manufactured silver nanoparticles (Ag-MNPs) in the wastewater treatment process.We studied the dissolution, uptake, and toxicity of Ag-MNP and sulfidized Ag-MNPs (sAg-MNPs) to a model soil organism, Caenorhabditis elegans. Our results show that reproduction was the most sensitive endpoint tested for both Ag-MNPs and sAg-MNPs. We also demonstrate that sulfidation not only decreases solubility of Ag-MNP, but also reduces the bioavailability of intact sAg-MNP. The relative contribution of released Ag(+) compared to intact particles to toxicity was concentration dependent. At lower total Ag concentration, a greater proportion of the toxicity could be explained by dissolved Ag, whereas at higher total Ag concentration, the toxicity appeared to be dominated by particle specific effects.

Authors+Show Affiliations

Starnes DL
Department of Plant and Soil Sciences, University of Kentucky, Lexington, KY 40546, USA.
Unrine JM
No affiliation info available
Starnes CP
No affiliation info available
Collin BE
No affiliation info available
Oostveen EK
No affiliation info available
Ma R
No affiliation info available
Lowry GV
No affiliation info available
Bertsch PM
No affiliation info available
Tsyusko OV
No affiliation info available

MeSH

AnimalsBiological AvailabilityCaenorhabditis elegansMetal NanoparticlesNanoparticlesSilverSoilSolubilityWaste Disposal, FluidWastewaterWater Pollutants, Chemical

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

25463719

Citation

Starnes, Daniel L., et al. "Impact of Sulfidation On the Bioavailability and Toxicity of Silver Nanoparticles to Caenorhabditis Elegans." Environmental Pollution (Barking, Essex : 1987), vol. 196, 2015, pp. 239-46.
Starnes DL, Unrine JM, Starnes CP, et al. Impact of sulfidation on the bioavailability and toxicity of silver nanoparticles to Caenorhabditis elegans. Environ Pollut. 2015;196:239-46.
Starnes, D. L., Unrine, J. M., Starnes, C. P., Collin, B. E., Oostveen, E. K., Ma, R., Lowry, G. V., Bertsch, P. M., & Tsyusko, O. V. (2015). Impact of sulfidation on the bioavailability and toxicity of silver nanoparticles to Caenorhabditis elegans. Environmental Pollution (Barking, Essex : 1987), 196, 239-46.
Starnes DL, et al. Impact of Sulfidation On the Bioavailability and Toxicity of Silver Nanoparticles to Caenorhabditis Elegans. Environ Pollut. 2015;196:239-46. PubMed PMID: 25463719.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of sulfidation on the bioavailability and toxicity of silver nanoparticles to Caenorhabditis elegans. AU - Starnes,Daniel L, AU - Unrine,Jason M, AU - Starnes,Catherine P, AU - Collin,Blanche E, AU - Oostveen,Emily K, AU - Ma,Rui, AU - Lowry,Gregory V, AU - Bertsch,Paul M, AU - Tsyusko,Olga V, PY - 2014/07/15/received PY - 2014/09/26/revised PY - 2014/10/02/accepted PY - 2014/12/3/entrez PY - 2014/12/3/pubmed PY - 2015/8/1/medline SP - 239 EP - 46 JF - Environmental pollution (Barking, Essex : 1987) JO - Environ Pollut VL - 196 N2 - Sulfidation is a major transformation product for manufactured silver nanoparticles (Ag-MNPs) in the wastewater treatment process.We studied the dissolution, uptake, and toxicity of Ag-MNP and sulfidized Ag-MNPs (sAg-MNPs) to a model soil organism, Caenorhabditis elegans. Our results show that reproduction was the most sensitive endpoint tested for both Ag-MNPs and sAg-MNPs. We also demonstrate that sulfidation not only decreases solubility of Ag-MNP, but also reduces the bioavailability of intact sAg-MNP. The relative contribution of released Ag(+) compared to intact particles to toxicity was concentration dependent. At lower total Ag concentration, a greater proportion of the toxicity could be explained by dissolved Ag, whereas at higher total Ag concentration, the toxicity appeared to be dominated by particle specific effects. SN - 1873-6424 UR - https://www.unboundmedicine.com/medline/citation/25463719/Impact_of_sulfidation_on_the_bioavailability_and_toxicity_of_silver_nanoparticles_to_Caenorhabditis_elegans_ DB - PRIME DP - Unbound Medicine ER -