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Airway responsiveness to histamine and leukotriene E4 in subjects with aspirin-induced asthma.
Am Rev Respir Dis. 1989 Jul; 140(1):148-53.AR

Abstract

Airway responsiveness to histamine and leukotriene E4 (LTE4) has been compared between five subjects with aspirin-induced asthma (AIA) and 15 asthmatic subjects without aspirin sensitivity (non-AIA). In the AIA group, the geometric mean doses of histamine and LTE4 causing a 35% fall in specific airway conductance (PD35) were 0.31 mumol and 0.17 nmol, respectively, and LTE4 was 1,870 times more potent than histamine. In the non-AIA group, the histamine and LTE4 PD35 doses were 0.40 mumol (non-AIA versus AIA, NS) and 2.8 nmol (non-AIA versus AIA, p = 0.002), respectively, and LTE4 was 145 times more potent than histamine in eliciting bronchoconstriction (non-AIA versus AIA, p = 0.001). After desensitization to aspirin the geometric mean histamine and LTE4 PD 35 in the AIA group changed to 0.19 mumol (NS) and 3.3 nmol (p = 0.007), respectively, and there was an average 33-fold reduction in the responsiveness of the airways to LTE4 relative to histamine (p less than 0.001). In five non-AIA subjects. Ingestion of 600 mg of aspirin daily did not lead to any significant change in airway responsiveness to histamine or to LTE4. These results demonstrate a selective and marked increase in airway responsiveness to LTE4 in subjects with AIA. The efficacy of desensitization may relate in part to a selective down-regulation of LTE4 receptors within the airways.

Authors+Show Affiliations

Department of Allergy and Allied Respiratory Disorders, UMDS, Guy's Hospital, London, United Kingdom.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

2546469

Citation

Arm, J P., et al. "Airway Responsiveness to Histamine and Leukotriene E4 in Subjects With Aspirin-induced Asthma." The American Review of Respiratory Disease, vol. 140, no. 1, 1989, pp. 148-53.
Arm JP, O'Hickey SP, Spur BW, et al. Airway responsiveness to histamine and leukotriene E4 in subjects with aspirin-induced asthma. Am Rev Respir Dis. 1989;140(1):148-53.
Arm, J. P., O'Hickey, S. P., Spur, B. W., & Lee, T. H. (1989). Airway responsiveness to histamine and leukotriene E4 in subjects with aspirin-induced asthma. The American Review of Respiratory Disease, 140(1), 148-53.
Arm JP, et al. Airway Responsiveness to Histamine and Leukotriene E4 in Subjects With Aspirin-induced Asthma. Am Rev Respir Dis. 1989;140(1):148-53. PubMed PMID: 2546469.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Airway responsiveness to histamine and leukotriene E4 in subjects with aspirin-induced asthma. AU - Arm,J P, AU - O'Hickey,S P, AU - Spur,B W, AU - Lee,T H, PY - 1989/7/1/pubmed PY - 1989/7/1/medline PY - 1989/7/1/entrez SP - 148 EP - 53 JF - The American review of respiratory disease JO - Am Rev Respir Dis VL - 140 IS - 1 N2 - Airway responsiveness to histamine and leukotriene E4 (LTE4) has been compared between five subjects with aspirin-induced asthma (AIA) and 15 asthmatic subjects without aspirin sensitivity (non-AIA). In the AIA group, the geometric mean doses of histamine and LTE4 causing a 35% fall in specific airway conductance (PD35) were 0.31 mumol and 0.17 nmol, respectively, and LTE4 was 1,870 times more potent than histamine. In the non-AIA group, the histamine and LTE4 PD35 doses were 0.40 mumol (non-AIA versus AIA, NS) and 2.8 nmol (non-AIA versus AIA, p = 0.002), respectively, and LTE4 was 145 times more potent than histamine in eliciting bronchoconstriction (non-AIA versus AIA, p = 0.001). After desensitization to aspirin the geometric mean histamine and LTE4 PD 35 in the AIA group changed to 0.19 mumol (NS) and 3.3 nmol (p = 0.007), respectively, and there was an average 33-fold reduction in the responsiveness of the airways to LTE4 relative to histamine (p less than 0.001). In five non-AIA subjects. Ingestion of 600 mg of aspirin daily did not lead to any significant change in airway responsiveness to histamine or to LTE4. These results demonstrate a selective and marked increase in airway responsiveness to LTE4 in subjects with AIA. The efficacy of desensitization may relate in part to a selective down-regulation of LTE4 receptors within the airways. SN - 0003-0805 UR - https://www.unboundmedicine.com/medline/citation/2546469/Airway_responsiveness_to_histamine_and_leukotriene_E4_in_subjects_with_aspirin_induced_asthma_ L2 - https://www.atsjournals.org/doi/10.1164/ajrccm/140.1.148?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -