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High loading MnO2 nanowires on graphene paper: facile electrochemical synthesis and use as flexible electrode for tracking hydrogen peroxide secretion in live cells.
Anal Chim Acta. 2015 Jan 01; 853:200-206.AC

Abstract

Recent progress in flexible and lightweight electrochemical sensor systems requires the development of paper-like electrode materials. Here, we report a facile and green synthesis of a new type of MnO2 nanowires-graphene nanohybrid paper by one-step electrochemical method. This strategy demonstrates a collection of unique features including the effective electrochemical reduction of graphene oxide (GO) paper and the high loading of MnO2 nanowires on electrochemical reduced GO (ERGO) paper. When used as flexible electrode for nonenzymatic detection of hydrogen peroxide (H2O2), MnO2-ERGO paper exhibits high electrocatalytic activity toward the redox of H2O2 as well as excellent stability, selectivity and reproducibility. The amperometric responses are linearly proportional to H2O2 concentration in the range 0.1-45.4 mM, with a detection limit of 10 μM (S/N=3) and detection sensitivity of 59.0 μA cm(-2) mM(-1). These outstanding sensing performances enable the practical application of MnO2-ERGO paper electrode for the real-time tracking H2O2 secretion by live cells macrophages. Therefore, the proposed graphene-based nanohybrid paper electrode with intrinsic flexibility, tailorable shapes and adjustable properties can contribute to the full realization of high-performance flexible electrode material used in point-of-care testing devices and portable instruments for in-vivo clinical diagnostics and on-site environmental monitoring.

Authors+Show Affiliations

Department of Chemistry and Chemical Engineering, Hubei Key Laboratory of Material Chemistry and Service Failure, Key Laboratory for Large-Format Battery Materials and System, Ministry of Education, Huazhong University of Science & Technology, Wuhan 430074, PR China.Department of Chemistry and Chemical Engineering, Hubei Key Laboratory of Material Chemistry and Service Failure, Key Laboratory for Large-Format Battery Materials and System, Ministry of Education, Huazhong University of Science & Technology, Wuhan 430074, PR China.Department of Chemistry and Chemical Engineering, Hubei Key Laboratory of Material Chemistry and Service Failure, Key Laboratory for Large-Format Battery Materials and System, Ministry of Education, Huazhong University of Science & Technology, Wuhan 430074, PR China.Department of Chemistry and Chemical Engineering, Hubei Key Laboratory of Material Chemistry and Service Failure, Key Laboratory for Large-Format Battery Materials and System, Ministry of Education, Huazhong University of Science & Technology, Wuhan 430074, PR China.Department of Chemistry and Chemical Engineering, Hubei Key Laboratory of Material Chemistry and Service Failure, Key Laboratory for Large-Format Battery Materials and System, Ministry of Education, Huazhong University of Science & Technology, Wuhan 430074, PR China.Department of Chemistry and Chemical Engineering, Hubei Key Laboratory of Material Chemistry and Service Failure, Key Laboratory for Large-Format Battery Materials and System, Ministry of Education, Huazhong University of Science & Technology, Wuhan 430074, PR China. Electronic address: liuhf@hust.edu.cn.Department of Chemistry and Chemical Engineering, Hubei Key Laboratory of Material Chemistry and Service Failure, Key Laboratory for Large-Format Battery Materials and System, Ministry of Education, Huazhong University of Science & Technology, Wuhan 430074, PR China. Electronic address: xiaofei@hust.edu.cn.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25467459

Citation

Dong, Shuang, et al. "High Loading MnO2 Nanowires On Graphene Paper: Facile Electrochemical Synthesis and Use as Flexible Electrode for Tracking Hydrogen Peroxide Secretion in Live Cells." Analytica Chimica Acta, vol. 853, 2015, pp. 200-206.
Dong S, Xi J, Wu Y, et al. High loading MnO2 nanowires on graphene paper: facile electrochemical synthesis and use as flexible electrode for tracking hydrogen peroxide secretion in live cells. Anal Chim Acta. 2015;853:200-206.
Dong, S., Xi, J., Wu, Y., Liu, H., Fu, C., Liu, H., & Xiao, F. (2015). High loading MnO2 nanowires on graphene paper: facile electrochemical synthesis and use as flexible electrode for tracking hydrogen peroxide secretion in live cells. Analytica Chimica Acta, 853, 200-206. https://doi.org/10.1016/j.aca.2014.08.004
Dong S, et al. High Loading MnO2 Nanowires On Graphene Paper: Facile Electrochemical Synthesis and Use as Flexible Electrode for Tracking Hydrogen Peroxide Secretion in Live Cells. Anal Chim Acta. 2015 Jan 1;853:200-206. PubMed PMID: 25467459.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High loading MnO2 nanowires on graphene paper: facile electrochemical synthesis and use as flexible electrode for tracking hydrogen peroxide secretion in live cells. AU - Dong,Shuang, AU - Xi,Jiangbo, AU - Wu,Yanan, AU - Liu,Hongwei, AU - Fu,Chaoyang, AU - Liu,Hongfang, AU - Xiao,Fei, Y1 - 2014/08/20/ PY - 2014/06/06/received PY - 2014/07/30/revised PY - 2014/08/05/accepted PY - 2014/12/4/entrez PY - 2014/12/4/pubmed PY - 2015/7/25/medline KW - Flexible electrode KW - Graphene-based nanohybrid paper KW - Live cell tracking KW - Nonenzymatic hydrogen peroxide sensing KW - One-step electrochemical synthesis SP - 200 EP - 206 JF - Analytica chimica acta JO - Anal. Chim. Acta VL - 853 N2 - Recent progress in flexible and lightweight electrochemical sensor systems requires the development of paper-like electrode materials. Here, we report a facile and green synthesis of a new type of MnO2 nanowires-graphene nanohybrid paper by one-step electrochemical method. This strategy demonstrates a collection of unique features including the effective electrochemical reduction of graphene oxide (GO) paper and the high loading of MnO2 nanowires on electrochemical reduced GO (ERGO) paper. When used as flexible electrode for nonenzymatic detection of hydrogen peroxide (H2O2), MnO2-ERGO paper exhibits high electrocatalytic activity toward the redox of H2O2 as well as excellent stability, selectivity and reproducibility. The amperometric responses are linearly proportional to H2O2 concentration in the range 0.1-45.4 mM, with a detection limit of 10 μM (S/N=3) and detection sensitivity of 59.0 μA cm(-2) mM(-1). These outstanding sensing performances enable the practical application of MnO2-ERGO paper electrode for the real-time tracking H2O2 secretion by live cells macrophages. Therefore, the proposed graphene-based nanohybrid paper electrode with intrinsic flexibility, tailorable shapes and adjustable properties can contribute to the full realization of high-performance flexible electrode material used in point-of-care testing devices and portable instruments for in-vivo clinical diagnostics and on-site environmental monitoring. SN - 1873-4324 UR - https://www.unboundmedicine.com/medline/citation/25467459/High_loading_MnO2_nanowires_on_graphene_paper:_facile_electrochemical_synthesis_and_use_as_flexible_electrode_for_tracking_hydrogen_peroxide_secretion_in_live_cells_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0003-2670(14)00951-9 DB - PRIME DP - Unbound Medicine ER -