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Novel triple reassortant H1N2 influenza viruses bearing six internal genes of the pandemic 2009/H1N1 influenza virus were detected in pigs in China.
J Clin Virol 2014; 61(4):529-34JC

Abstract

BACKGROUND

The pandemic A/H1N1 influenza viruses emerged in both Mexico and the United States in March 2009, and were transmitted efficiently in the human population. Transmissions of the pandemic 2009/H1N1 virus from humans to poultry and other species of mammals were reported from several continents during the course of the 2009 H1N1 pandemic. Reassortant H1N1, H1N2, and H3N2 viruses containing genes of the pandemic 2009/H1N1 viruses appeared in pigs in some countries.

STUDY DESIGN

In winter of 2012, a total of 2600 nasal swabs were collected from healthy pigs in slaughterhouses located throughout 10 provinces in China. The isolated viruses were subjected to genetic and antigenic analysis. Two novel triple-reassortant H1N2 influenza viruses were isolated from swine in China in 2012, with the HA gene derived from Eurasian avian-like swine H1N1, the NA gene from North American swine H1N2, and the six internal genes from the pandemic 2009/H1N1 viruses. The two viruses had similar antigenic features and some significant changes in antigenic characteristics emerged when compared to the previously identified isolates.

CONCLUSION

We inferred that the novel reassortant viruses in China may have arisen from the accumulation of the three types of influenza viruses, which further indicates that swine herds serve as "mixing vessels" for influenza viruses. Influenza virus reassortment is an ongoing process, and our findings highlight the urgent need for continued influenza surveillance among swine herds.

Authors+Show Affiliations

State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150001, PR China.State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150001, PR China.State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150001, PR China.State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150001, PR China.State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150001, PR China.State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150001, PR China. Electronic address: chenhualan@caas.cn.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25467861

Citation

Qiao, Chuanling, et al. "Novel Triple Reassortant H1N2 Influenza Viruses Bearing Six Internal Genes of the Pandemic 2009/H1N1 Influenza Virus Were Detected in Pigs in China." Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology, vol. 61, no. 4, 2014, pp. 529-34.
Qiao C, Liu L, Yang H, et al. Novel triple reassortant H1N2 influenza viruses bearing six internal genes of the pandemic 2009/H1N1 influenza virus were detected in pigs in China. J Clin Virol. 2014;61(4):529-34.
Qiao, C., Liu, L., Yang, H., Chen, Y., Xu, H., & Chen, H. (2014). Novel triple reassortant H1N2 influenza viruses bearing six internal genes of the pandemic 2009/H1N1 influenza virus were detected in pigs in China. Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology, 61(4), pp. 529-34. doi:10.1016/j.jcv.2014.10.014.
Qiao C, et al. Novel Triple Reassortant H1N2 Influenza Viruses Bearing Six Internal Genes of the Pandemic 2009/H1N1 Influenza Virus Were Detected in Pigs in China. J Clin Virol. 2014;61(4):529-34. PubMed PMID: 25467861.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Novel triple reassortant H1N2 influenza viruses bearing six internal genes of the pandemic 2009/H1N1 influenza virus were detected in pigs in China. AU - Qiao,Chuanling, AU - Liu,Liping, AU - Yang,Huanliang, AU - Chen,Yan, AU - Xu,Huiyang, AU - Chen,Hualan, Y1 - 2014/10/28/ PY - 2014/08/21/received PY - 2014/09/30/revised PY - 2014/10/20/accepted PY - 2014/12/4/entrez PY - 2014/12/4/pubmed PY - 2015/7/15/medline KW - Genetic analysis KW - H1N2 KW - Novel reassortant KW - Swine influenza virus SP - 529 EP - 34 JF - Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology JO - J. Clin. Virol. VL - 61 IS - 4 N2 - BACKGROUND: The pandemic A/H1N1 influenza viruses emerged in both Mexico and the United States in March 2009, and were transmitted efficiently in the human population. Transmissions of the pandemic 2009/H1N1 virus from humans to poultry and other species of mammals were reported from several continents during the course of the 2009 H1N1 pandemic. Reassortant H1N1, H1N2, and H3N2 viruses containing genes of the pandemic 2009/H1N1 viruses appeared in pigs in some countries. STUDY DESIGN: In winter of 2012, a total of 2600 nasal swabs were collected from healthy pigs in slaughterhouses located throughout 10 provinces in China. The isolated viruses were subjected to genetic and antigenic analysis. Two novel triple-reassortant H1N2 influenza viruses were isolated from swine in China in 2012, with the HA gene derived from Eurasian avian-like swine H1N1, the NA gene from North American swine H1N2, and the six internal genes from the pandemic 2009/H1N1 viruses. The two viruses had similar antigenic features and some significant changes in antigenic characteristics emerged when compared to the previously identified isolates. CONCLUSION: We inferred that the novel reassortant viruses in China may have arisen from the accumulation of the three types of influenza viruses, which further indicates that swine herds serve as "mixing vessels" for influenza viruses. Influenza virus reassortment is an ongoing process, and our findings highlight the urgent need for continued influenza surveillance among swine herds. SN - 1873-5967 UR - https://www.unboundmedicine.com/medline/citation/25467861/Novel_triple_reassortant_H1N2_influenza_viruses_bearing_six_internal_genes_of_the_pandemic_2009/H1N1_influenza_virus_were_detected_in_pigs_in_China_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1386-6532(14)00401-6 DB - PRIME DP - Unbound Medicine ER -