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Susceptibility of Stenotrophomonas maltophilia clinical isolates to antibiotics and contact lens multipurpose disinfecting solutions.
Invest Ophthalmol Vis Sci. 2014 Dec 02; 55(12):8475-9.IO

Abstract

PURPOSE

To determine the susceptibility of Stenotrophomonas maltophilia to various antibiotics and contact lens multipurpose disinfecting solutions.

METHODS

Forty S. maltophilia strains from contact lens cases, contact lenses, or eye swabs of contact lens wearers including 27 asymptomatic wearers and 13 keratitis patients were examined for their susceptibility to different antibiotics, using a disc diffusion assay, and to multipurpose disinfecting solutions using a broth microdilution method.

RESULTS

Certain strains were resistant to aztreonum (15%), imipenem (93%), chroramphenicol (13%), and cefepime (8%). Two of those strains were multidrug resistant. All strains were sensitive to trimethoprim-sulfamethoxazole, tigecycline, ceftazidime, and fluoroquinolones. Overall, the minimum inhibitory concentration (MIC) for all strains was significantly higher (P < 0.05) for AQuify (50% dilution) and OPTI-FREE RepleniSH (25%) than all other multipurpose contact lens disinfecting solutions (MPDS) (3%-14%, except RepleniSH versus MeniCare Soft [14%]). AQuify, OPTI-FREE RepleniSH, and MeniCare Soft had significantly higher minimum bactericidal concentrations (undiluted MPDS) than other disinfecting solutions (P < 0.05).

CONCLUSIONS

The Australian ocular isolates of S. maltophilia remain susceptible to trimethoprim-sulfamethozole, tigecycline, and most fluoroquinolones. However, the isolates showed resistance to certain multipurpose disinfecting solutions.

Authors+Show Affiliations

Department of Ophthalmology, Kinki University Faculty of Medicine, Osaka, Japan Brien Holden Vision Institute, University of New South Wales, Sydney, Australia.Brien Holden Vision Institute, University of New South Wales, Sydney, Australia School of Optometry and Vision Science, University of New South Wales, Sydney, Australia.School of Optometry and Vision Science, University of New South Wales, Sydney, Australia.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25468893

Citation

Watanabe, Keizo, et al. "Susceptibility of Stenotrophomonas Maltophilia Clinical Isolates to Antibiotics and Contact Lens Multipurpose Disinfecting Solutions." Investigative Ophthalmology & Visual Science, vol. 55, no. 12, 2014, pp. 8475-9.
Watanabe K, Zhu H, Willcox M. Susceptibility of Stenotrophomonas maltophilia clinical isolates to antibiotics and contact lens multipurpose disinfecting solutions. Invest Ophthalmol Vis Sci. 2014;55(12):8475-9.
Watanabe, K., Zhu, H., & Willcox, M. (2014). Susceptibility of Stenotrophomonas maltophilia clinical isolates to antibiotics and contact lens multipurpose disinfecting solutions. Investigative Ophthalmology & Visual Science, 55(12), 8475-9. https://doi.org/10.1167/iovs.14-15667
Watanabe K, Zhu H, Willcox M. Susceptibility of Stenotrophomonas Maltophilia Clinical Isolates to Antibiotics and Contact Lens Multipurpose Disinfecting Solutions. Invest Ophthalmol Vis Sci. 2014 Dec 2;55(12):8475-9. PubMed PMID: 25468893.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Susceptibility of Stenotrophomonas maltophilia clinical isolates to antibiotics and contact lens multipurpose disinfecting solutions. AU - Watanabe,Keizo, AU - Zhu,Hua, AU - Willcox,Mark, Y1 - 2014/12/02/ PY - 2014/12/4/entrez PY - 2014/12/4/pubmed PY - 2015/1/27/medline KW - Stenotrophomonas KW - antibiotics KW - disinfection SP - 8475 EP - 9 JF - Investigative ophthalmology & visual science JO - Invest Ophthalmol Vis Sci VL - 55 IS - 12 N2 - PURPOSE: To determine the susceptibility of Stenotrophomonas maltophilia to various antibiotics and contact lens multipurpose disinfecting solutions. METHODS: Forty S. maltophilia strains from contact lens cases, contact lenses, or eye swabs of contact lens wearers including 27 asymptomatic wearers and 13 keratitis patients were examined for their susceptibility to different antibiotics, using a disc diffusion assay, and to multipurpose disinfecting solutions using a broth microdilution method. RESULTS: Certain strains were resistant to aztreonum (15%), imipenem (93%), chroramphenicol (13%), and cefepime (8%). Two of those strains were multidrug resistant. All strains were sensitive to trimethoprim-sulfamethoxazole, tigecycline, ceftazidime, and fluoroquinolones. Overall, the minimum inhibitory concentration (MIC) for all strains was significantly higher (P < 0.05) for AQuify (50% dilution) and OPTI-FREE RepleniSH (25%) than all other multipurpose contact lens disinfecting solutions (MPDS) (3%-14%, except RepleniSH versus MeniCare Soft [14%]). AQuify, OPTI-FREE RepleniSH, and MeniCare Soft had significantly higher minimum bactericidal concentrations (undiluted MPDS) than other disinfecting solutions (P < 0.05). CONCLUSIONS: The Australian ocular isolates of S. maltophilia remain susceptible to trimethoprim-sulfamethozole, tigecycline, and most fluoroquinolones. However, the isolates showed resistance to certain multipurpose disinfecting solutions. SN - 1552-5783 UR - https://www.unboundmedicine.com/medline/citation/25468893/Susceptibility_of_Stenotrophomonas_maltophilia_clinical_isolates_to_antibiotics_and_contact_lens_multipurpose_disinfecting_solutions_ L2 - https://iovs.arvojournals.org/article.aspx?doi=10.1167/iovs.14-15667 DB - PRIME DP - Unbound Medicine ER -