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Micronutrient levels and supplement intake in pregnancy after bariatric surgery: a prospective cohort study.

Abstract

BACKGROUND

Studies report frequent micronutrient deficiencies after bariatric surgery, but less is known about micronutrient levels of pregnant women after bariatric surgery.

OBJECTIVE

To prospectively evaluate micronutrient levels and supplement intake in pregnancy following bariatric surgery.

DESIGN

A multicenter prospective cohort study including women with restrictive or malabsorptive types of bariatric surgery. Nutritional deficiencies, together with supplement intake, were screened during pregnancy.

RESULTS

The total population included 18 women in the restrictive and 31 in the malabsorptive group. Most micronutrients were depleted and declined significantly during pregnancy. The proportion of women with low vitamin A and B-1 levels increased to respectively 58 and 17% at delivery (P = 0.005 and 0.002). The proportion of women with vitamin D deficiency decreased from 14% at trimester 1 to 6% at delivery (P = 0.030). Mild anemia was found in respectively 22 and 40% of the women at trimester 1 and delivery. In the first trimester, most women took a multivitamin (57.1%). In the second and third trimester, the majority took additional supplements (69.4 and 73.5%). No associations were found between supplement intake and micronutrient deficiencies.

CONCLUSION

Pregnant women with bariatric surgery show frequent low micronutrient levels. Supplementation partially normalizes low levels of micronutrients.

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  • Authors+Show Affiliations

    ,

    Department of Obstetrics and Gynecology, University Hospitals Leuven, Leuven, Belgium; Department of Development and Regeneration, KU Leuven, Leuven, Belgium.

    ,

    Department of Public Health and Primary Care, KU Leuven, Leuven, Belgium.

    ,

    Department of Development and Regeneration, KU Leuven, Leuven, Belgium.

    ,

    Jessa Hospital, 3500 Hasselt, Belgium.

    ,

    Department of Obstetrics and Gynecology, University Hospitals Leuven, Leuven, Belgium; Department of Development and Regeneration, KU Leuven, Leuven, Belgium; Hospital Oost-Limburg (ZOL), 3600 Genk, Belgium.

    Department of Public Health and Primary Care, KU Leuven, Leuven, Belgium.

    Source

    PloS one 9:12 2014 pg e114192

    MeSH

    Adolescent
    Adult
    Anemia
    Bariatric Surgery
    Cholecalciferol
    Cohort Studies
    Dietary Supplements
    Female
    Folic Acid
    Humans
    Micronutrients
    Obesity
    Pregnancy
    Pregnancy Complications
    Pregnancy Trimester, Third
    Prospective Studies
    Vitamin A
    Vitamin B 12
    Vitamin D Deficiency
    Vitamins
    Young Adult

    Pub Type(s)

    Journal Article
    Multicenter Study
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    25470614

    Citation

    Devlieger, Roland, et al. "Micronutrient Levels and Supplement Intake in Pregnancy After Bariatric Surgery: a Prospective Cohort Study." PloS One, vol. 9, no. 12, 2014, pp. e114192.
    Devlieger R, Guelinckx I, Jans G, et al. Micronutrient levels and supplement intake in pregnancy after bariatric surgery: a prospective cohort study. PLoS ONE. 2014;9(12):e114192.
    Devlieger, R., Guelinckx, I., Jans, G., Voets, W., Vanholsbeke, C., & Vansant, G. (2014). Micronutrient levels and supplement intake in pregnancy after bariatric surgery: a prospective cohort study. PloS One, 9(12), pp. e114192. doi:10.1371/journal.pone.0114192.
    Devlieger R, et al. Micronutrient Levels and Supplement Intake in Pregnancy After Bariatric Surgery: a Prospective Cohort Study. PLoS ONE. 2014;9(12):e114192. PubMed PMID: 25470614.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Micronutrient levels and supplement intake in pregnancy after bariatric surgery: a prospective cohort study. AU - Devlieger,Roland, AU - Guelinckx,Isabelle, AU - Jans,Goele, AU - Voets,Willy, AU - Vanholsbeke,Caroline, AU - Vansant,Greet, Y1 - 2014/12/03/ PY - 2014/06/06/received PY - 2014/11/05/accepted PY - 2014/12/4/entrez PY - 2014/12/4/pubmed PY - 2015/12/15/medline SP - e114192 EP - e114192 JF - PloS one JO - PLoS ONE VL - 9 IS - 12 N2 - BACKGROUND: Studies report frequent micronutrient deficiencies after bariatric surgery, but less is known about micronutrient levels of pregnant women after bariatric surgery. OBJECTIVE: To prospectively evaluate micronutrient levels and supplement intake in pregnancy following bariatric surgery. DESIGN: A multicenter prospective cohort study including women with restrictive or malabsorptive types of bariatric surgery. Nutritional deficiencies, together with supplement intake, were screened during pregnancy. RESULTS: The total population included 18 women in the restrictive and 31 in the malabsorptive group. Most micronutrients were depleted and declined significantly during pregnancy. The proportion of women with low vitamin A and B-1 levels increased to respectively 58 and 17% at delivery (P = 0.005 and 0.002). The proportion of women with vitamin D deficiency decreased from 14% at trimester 1 to 6% at delivery (P = 0.030). Mild anemia was found in respectively 22 and 40% of the women at trimester 1 and delivery. In the first trimester, most women took a multivitamin (57.1%). In the second and third trimester, the majority took additional supplements (69.4 and 73.5%). No associations were found between supplement intake and micronutrient deficiencies. CONCLUSION: Pregnant women with bariatric surgery show frequent low micronutrient levels. Supplementation partially normalizes low levels of micronutrients. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/25470614/Micronutrient_levels_and_supplement_intake_in_pregnancy_after_bariatric_surgery:_a_prospective_cohort_study_ L2 - http://dx.plos.org/10.1371/journal.pone.0114192 DB - PRIME DP - Unbound Medicine ER -