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The value of different insulin resistance indices in assessment of non-alcoholic fatty liver disease in overweight/obese children.
Diabetes Metab Syndr. 2015 Apr-Jun; 9(2):114-9.DM

Abstract

OBJECTIVE

The aim of the present study was to determine the association between insulin resistance (IR) and both non-alcoholic fatty liver disease (NAFLD) and metabolic syndrome (MetS) in a group of Egyptian overweight/obese children and adolescents and to evaluate different IR indices in detection of NAFLD.

PATIENTS AND METHODS

The study included 76 overweight/obese children aged 2-15 years; 52.6% were males. Laboratory analysis included fasting blood glucose, serum insulin, lipid profile, liver biochemical profile, and liver ultrasound. IR was calculated using the following indices; the homeostasis model assessment method (HOMA-IR), the quantitative insulin-sensitivity check index (QUICKI) and hepatic insulin sensitivity. The National Cholesterol Education Program Adult Treatment Panel III criteria were used to estimate prevalence of MetS. Liver biopsy was done when medically indicated and accepted by parents.

RESULTS

IR was detected in 43.4% and 34.2% by using QUICKI and HOMA, respectively. MetS was detected in 36.8% and NAFLD was detected in 45.5% among those performing liver biopsy. Cases with NAFLD had more frequent IR than children with normal histology. QUICKI showed significant difference between normal subjects and both steatosis and non-alcoholic steatohepatitis; while HOMA-IR was sensitive in cases with NASH only. MetS was present in 100% of patients with NASH and in 75% of those with steatosis and they were all obese. Patients with NASH had significantly higher ALT than those with normal histology.

CONCLUSION

IR was significantly associated with NAFLD. QUICKI is considered more sensitive than HOMA-IR in differentiating simple steatosis from normal liver histology.

Authors+Show Affiliations

Department of Pediatrics, Cairo University, Cairo, Egypt. Electronic address: hanaakaraksy@kasralainy.edu.eg.Department of Pediatrics, Cairo University, Cairo, Egypt.Department of Pediatrics, National Hepatology and Tropical Medicine Research Institute, Cairo, Egypt.Department of Pediatrics, Cairo University, Cairo, Egypt.Department of Chemical Pathology, Cairo University, Cairo, Egypt.Department of Pediatrics, Cairo University, Cairo, Egypt.Department of Pathology, Cairo University, Cairo, Egypt.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25470627

Citation

El-Karaksy, Hanaa M., et al. "The Value of Different Insulin Resistance Indices in Assessment of Non-alcoholic Fatty Liver Disease in Overweight/obese Children." Diabetes & Metabolic Syndrome, vol. 9, no. 2, 2015, pp. 114-9.
El-Karaksy HM, El-Raziky MS, Fouad HM, et al. The value of different insulin resistance indices in assessment of non-alcoholic fatty liver disease in overweight/obese children. Diabetes Metab Syndr. 2015;9(2):114-9.
El-Karaksy, H. M., El-Raziky, M. S., Fouad, H. M., Anwar, G. M., El-Mougy, F. M., El-Koofy, N. M., & El-Hennawy, A. M. (2015). The value of different insulin resistance indices in assessment of non-alcoholic fatty liver disease in overweight/obese children. Diabetes & Metabolic Syndrome, 9(2), 114-9. https://doi.org/10.1016/j.dsx.2013.10.008
El-Karaksy HM, et al. The Value of Different Insulin Resistance Indices in Assessment of Non-alcoholic Fatty Liver Disease in Overweight/obese Children. Diabetes Metab Syndr. 2015 Apr-Jun;9(2):114-9. PubMed PMID: 25470627.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The value of different insulin resistance indices in assessment of non-alcoholic fatty liver disease in overweight/obese children. AU - El-Karaksy,Hanaa M, AU - El-Raziky,Mona S, AU - Fouad,Hanan M, AU - Anwar,Ghada M, AU - El-Mougy,Fatma M, AU - El-Koofy,Nehal M, AU - El-Hennawy,Ahmad M, Y1 - 2013/11/14/ PY - 2014/12/4/entrez PY - 2014/12/4/pubmed PY - 2016/2/13/medline KW - Children KW - Insulin resistance KW - Metabolic syndrome KW - Non-alcoholic fatty liver disease KW - Obesity KW - Overweight SP - 114 EP - 9 JF - Diabetes & metabolic syndrome JO - Diabetes Metab Syndr VL - 9 IS - 2 N2 - OBJECTIVE: The aim of the present study was to determine the association between insulin resistance (IR) and both non-alcoholic fatty liver disease (NAFLD) and metabolic syndrome (MetS) in a group of Egyptian overweight/obese children and adolescents and to evaluate different IR indices in detection of NAFLD. PATIENTS AND METHODS: The study included 76 overweight/obese children aged 2-15 years; 52.6% were males. Laboratory analysis included fasting blood glucose, serum insulin, lipid profile, liver biochemical profile, and liver ultrasound. IR was calculated using the following indices; the homeostasis model assessment method (HOMA-IR), the quantitative insulin-sensitivity check index (QUICKI) and hepatic insulin sensitivity. The National Cholesterol Education Program Adult Treatment Panel III criteria were used to estimate prevalence of MetS. Liver biopsy was done when medically indicated and accepted by parents. RESULTS: IR was detected in 43.4% and 34.2% by using QUICKI and HOMA, respectively. MetS was detected in 36.8% and NAFLD was detected in 45.5% among those performing liver biopsy. Cases with NAFLD had more frequent IR than children with normal histology. QUICKI showed significant difference between normal subjects and both steatosis and non-alcoholic steatohepatitis; while HOMA-IR was sensitive in cases with NASH only. MetS was present in 100% of patients with NASH and in 75% of those with steatosis and they were all obese. Patients with NASH had significantly higher ALT than those with normal histology. CONCLUSION: IR was significantly associated with NAFLD. QUICKI is considered more sensitive than HOMA-IR in differentiating simple steatosis from normal liver histology. SN - 1878-0334 UR - https://www.unboundmedicine.com/medline/citation/25470627/The_value_of_different_insulin_resistance_indices_in_assessment_of_non_alcoholic_fatty_liver_disease_in_overweight/obese_children_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1871-4021(13)00098-2 DB - PRIME DP - Unbound Medicine ER -