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[Extramammary Paget´s disease of the vulva - a case report].
Ceska Gynekol 2014; 79(5):394-8CG

Abstract

OBJECTIVE

Analysis of one case of vulvar extramammary Paget´s disease (EMPD) and associated well differentiated endometrial adenocarcinoma.Desing: A case report.

METHODS AND RESULTS

On this case report we present current theoretical knowledge about EMPD, difficulty of diagnostics, treatment and dispensarization the patients with this rare intraepithelial non-squamous neoplasia. We report a rare case of a 62 years old female patient with extramammary Paget´s disease of vulva and associated well differentiated endometrial adenocarcinoma.

CONCLUSIONS

EMPD is a rare intraephitelial non-squamous neoplasia, which represents less then 1% vulvar tumors. Predominantly it affects white women between 60 and 80 years of age. EMPD occurs in cutaneous areas bearing apocrine glands - vulva, perineum, perianal area, axilla, penis, scrotum and rarely region of tights or buttocks. It is characterized microscopically by the presence of specific tumor cells called Paget´s cells - atypical large cells with pale clear cytoplasm and large round nuclei.

KEYWORDS

extramammary Paget´s disease, EMPD, Paget´s cells, vulvectomy, imiquimod 5%, photodynamic therapy, imunotherapy, radiotherapy.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

cze

PubMed ID

25472459

Citation

Kolářová, D, et al. "[Extramammary Paget´s Disease of the Vulva - a Case Report]." Ceska Gynekologie, vol. 79, no. 5, 2014, pp. 394-8.
Kolářová D, Havránková A, Líbalová P, et al. [Extramammary Paget´s disease of the vulva - a case report]. Ceska Gynekol. 2014;79(5):394-8.
Kolářová, D., Havránková, A., Líbalová, P., Frühaufová, S., Vernerová, Z., & Kučera, E. (2014). [Extramammary Paget´s disease of the vulva - a case report]. Ceska Gynekologie, 79(5), pp. 394-8.
Kolářová D, et al. [Extramammary Paget´s Disease of the Vulva - a Case Report]. Ceska Gynekol. 2014;79(5):394-8. PubMed PMID: 25472459.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Extramammary Paget´s disease of the vulva - a case report]. AU - Kolářová,D, AU - Havránková,A, AU - Líbalová,P, AU - Frühaufová,S, AU - Vernerová,Z, AU - Kučera,E, PY - 2014/12/5/entrez PY - 2014/12/5/pubmed PY - 2014/12/5/medline SP - 394 EP - 8 JF - Ceska gynekologie JO - Ceska Gynekol VL - 79 IS - 5 N2 - OBJECTIVE: Analysis of one case of vulvar extramammary Paget´s disease (EMPD) and associated well differentiated endometrial adenocarcinoma.Desing: A case report. METHODS AND RESULTS: On this case report we present current theoretical knowledge about EMPD, difficulty of diagnostics, treatment and dispensarization the patients with this rare intraepithelial non-squamous neoplasia. We report a rare case of a 62 years old female patient with extramammary Paget´s disease of vulva and associated well differentiated endometrial adenocarcinoma. CONCLUSIONS: EMPD is a rare intraephitelial non-squamous neoplasia, which represents less then 1% vulvar tumors. Predominantly it affects white women between 60 and 80 years of age. EMPD occurs in cutaneous areas bearing apocrine glands - vulva, perineum, perianal area, axilla, penis, scrotum and rarely region of tights or buttocks. It is characterized microscopically by the presence of specific tumor cells called Paget´s cells - atypical large cells with pale clear cytoplasm and large round nuclei. KEYWORDS: extramammary Paget´s disease, EMPD, Paget´s cells, vulvectomy, imiquimod 5%, photodynamic therapy, imunotherapy, radiotherapy. SN - 1210-7832 UR - https://www.unboundmedicine.com/medline/citation/25472459/[Extramammary_Paget´s_disease_of_the_vulva___a_case_report]_ L2 - https://www.prolekare.cz/linkout/50525 DB - PRIME DP - Unbound Medicine ER -