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Improved blend and tablet properties of fine pharmaceutical powders via dry particle coating.
Int J Pharm. 2015 Jan 30; 478(2):447-55.IJ

Abstract

The improvements in the flow and packing of fine pharmaceutical powder blends due to dry coating of micronized acetaminophen (mAPAP, ∼11μm), a model poorly flowing drug, are quantified. Poor flow and packing density of fine excipients (∼20μm) allowed testing the hypothesis that dry coating of cohesive API may counteract poor flow and packing of fine pharmaceutical powder blends. Further, fine excipients could improve compaction and reduce segregation tendency. It was found that flow function coefficient (FFC) and bulk density enhancements for 10%, 30%, and 60% (w/w), API loading blends with dry coated API are significantly higher than those without coated silica. At the highest API loading, for which coarser excipients were also used as reference, the flow and packing of dry coated mAPAP blends were significantly increased regardless of the excipient particle size, exceeding those of a well compacting excipient, Avicel 102. In addition, tensile strength of tablets with fine excipients was significantly higher, indicating improved compactibility. These results show for the first time that dry coating of fine, cohesive API powder leads to significantly improved flow and packing of high API loading blends consisting of fine excipients, while achieving improved tablet compactibility, suggesting suitability for direct compaction.

Authors+Show Affiliations

New Jersey Center for Engineered Particulates, New Jersey Institute of Technology, Newark, NJ 07102, USA.New Jersey Center for Engineered Particulates, New Jersey Institute of Technology, Newark, NJ 07102, USA.New Jersey Center for Engineered Particulates, New Jersey Institute of Technology, Newark, NJ 07102, USA.New Jersey Center for Engineered Particulates, New Jersey Institute of Technology, Newark, NJ 07102, USA. Electronic address: dave@njit.edu.

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

25475016

Citation

Huang, Zhonghui, et al. "Improved Blend and Tablet Properties of Fine Pharmaceutical Powders Via Dry Particle Coating." International Journal of Pharmaceutics, vol. 478, no. 2, 2015, pp. 447-55.
Huang Z, Scicolone JV, Han X, et al. Improved blend and tablet properties of fine pharmaceutical powders via dry particle coating. Int J Pharm. 2015;478(2):447-55.
Huang, Z., Scicolone, J. V., Han, X., & Davé, R. N. (2015). Improved blend and tablet properties of fine pharmaceutical powders via dry particle coating. International Journal of Pharmaceutics, 478(2), 447-55. https://doi.org/10.1016/j.ijpharm.2014.11.068
Huang Z, et al. Improved Blend and Tablet Properties of Fine Pharmaceutical Powders Via Dry Particle Coating. Int J Pharm. 2015 Jan 30;478(2):447-55. PubMed PMID: 25475016.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Improved blend and tablet properties of fine pharmaceutical powders via dry particle coating. AU - Huang,Zhonghui, AU - Scicolone,James V, AU - Han,Xi, AU - Davé,Rajesh N, Y1 - 2014/12/02/ PY - 2014/08/02/received PY - 2014/11/11/revised PY - 2014/11/28/accepted PY - 2014/12/6/entrez PY - 2014/12/6/pubmed PY - 2015/9/29/medline KW - Dry coating KW - Fine cohesive API powder KW - Fine excipients KW - Flow improvement KW - Pharmaceutical blends KW - Tablet hardness SP - 447 EP - 55 JF - International journal of pharmaceutics JO - Int J Pharm VL - 478 IS - 2 N2 - The improvements in the flow and packing of fine pharmaceutical powder blends due to dry coating of micronized acetaminophen (mAPAP, ∼11μm), a model poorly flowing drug, are quantified. Poor flow and packing density of fine excipients (∼20μm) allowed testing the hypothesis that dry coating of cohesive API may counteract poor flow and packing of fine pharmaceutical powder blends. Further, fine excipients could improve compaction and reduce segregation tendency. It was found that flow function coefficient (FFC) and bulk density enhancements for 10%, 30%, and 60% (w/w), API loading blends with dry coated API are significantly higher than those without coated silica. At the highest API loading, for which coarser excipients were also used as reference, the flow and packing of dry coated mAPAP blends were significantly increased regardless of the excipient particle size, exceeding those of a well compacting excipient, Avicel 102. In addition, tensile strength of tablets with fine excipients was significantly higher, indicating improved compactibility. These results show for the first time that dry coating of fine, cohesive API powder leads to significantly improved flow and packing of high API loading blends consisting of fine excipients, while achieving improved tablet compactibility, suggesting suitability for direct compaction. SN - 1873-3476 UR - https://www.unboundmedicine.com/medline/citation/25475016/Improved_blend_and_tablet_properties_of_fine_pharmaceutical_powders_via_dry_particle_coating_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-5173(14)00883-7 DB - PRIME DP - Unbound Medicine ER -