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Identification of candidate genes for Parkinson's disease through blood transcriptome analysis in LRRK2-G2019S carriers, idiopathic cases, and controls.
Neurobiol Aging. 2015 Feb; 36(2):1105-9.NA

Abstract

The commonest known cause of Parkinson's disease (PD) is the G2019S mutation of the LRRK2 gene, but this mutation is not sufficient for causing PD, and many carriers of the mutation never develop PD symptoms during life. Differences at the expression level of certain genes, resulting from either genetic variations or environmental interactions, might be one of the mechanisms underlying differential risks for developing both idiopathic and genetic PD. To identify the genes involved in PD pathogenesis, we compared genome-wide gene expression (RNA-seq) in peripheral blood of 20 PD patients carrying the G2019S mutation of the LRRK2 gene, 20 asymptomatic carriers of the mutation, 20 subjects with idiopathic PD, 20 controls and 7 PD patients before and after initiating dopaminergic therapy. We identified 13 common genes (ADARB2, CEACAM6, CNTNAP2, COL19A1, DEF4, DRAXIN, FCER2, HBG1, NCAPG2, PVRL2, SLC2A14, SNCA, and TCL1B) showing significant differential expression between G2019S-associated PD and asymptomatic carriers and also between idiopathic PD and controls but not between untreated and treated patients. Some of these genes are functionally involved in the processes known to be involved in PD pathogenesis, such as Akt signaling, glucose metabolism, or immunity. We consider that these genes merit further attention in future studies as potential candidate genes involved in both idiopathic and LRRK2-G2019S-associated forms of PD.

Authors+Show Affiliations

Service of Neurology, University Hospital Marqués de Valdecilla (IDIVAL), University of Cantabria (UC), Santander, Spain; Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain. Electronic address: jinfante@humv.es.Institute of Biomedicine and Biotechnology of Cantabria, Spanish National Research Council (CSIC), Santander, Spain.Service of Neurology, University Hospital Marqués de Valdecilla (IDIVAL), University of Cantabria (UC), Santander, Spain; Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.Service of Neurology, University Hospital Marqués de Valdecilla (IDIVAL), University of Cantabria (UC), Santander, Spain; Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.Service of Neurology, University Hospital Marqués de Valdecilla (IDIVAL), University of Cantabria (UC), Santander, Spain; Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.Service of Neurology, University Hospital Marqués de Valdecilla (IDIVAL), University of Cantabria (UC), Santander, Spain.Service of Neurology, University Hospital Marqués de Valdecilla (IDIVAL), University of Cantabria (UC), Santander, Spain; Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.Service of Neurology, University Hospital Marqués de Valdecilla (IDIVAL), University of Cantabria (UC), Santander, Spain; Centro de Investigación en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.Institute of Biomedicine and Biotechnology of Cantabria, Spanish National Research Council (CSIC), Santander, Spain.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25475535

Citation

Infante, Jon, et al. "Identification of Candidate Genes for Parkinson's Disease Through Blood Transcriptome Analysis in LRRK2-G2019S Carriers, Idiopathic Cases, and Controls." Neurobiology of Aging, vol. 36, no. 2, 2015, pp. 1105-9.
Infante J, Prieto C, Sierra M, et al. Identification of candidate genes for Parkinson's disease through blood transcriptome analysis in LRRK2-G2019S carriers, idiopathic cases, and controls. Neurobiol Aging. 2015;36(2):1105-9.
Infante, J., Prieto, C., Sierra, M., Sánchez-Juan, P., González-Aramburu, I., Sánchez-Quintana, C., Berciano, J., Combarros, O., & Sainz, J. (2015). Identification of candidate genes for Parkinson's disease through blood transcriptome analysis in LRRK2-G2019S carriers, idiopathic cases, and controls. Neurobiology of Aging, 36(2), 1105-9. https://doi.org/10.1016/j.neurobiolaging.2014.10.039
Infante J, et al. Identification of Candidate Genes for Parkinson's Disease Through Blood Transcriptome Analysis in LRRK2-G2019S Carriers, Idiopathic Cases, and Controls. Neurobiol Aging. 2015;36(2):1105-9. PubMed PMID: 25475535.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Identification of candidate genes for Parkinson's disease through blood transcriptome analysis in LRRK2-G2019S carriers, idiopathic cases, and controls. AU - Infante,Jon, AU - Prieto,Carlos, AU - Sierra,María, AU - Sánchez-Juan,Pascual, AU - González-Aramburu,Isabel, AU - Sánchez-Quintana,Coro, AU - Berciano,José, AU - Combarros,Onofre, AU - Sainz,Jesús, Y1 - 2014/11/05/ PY - 2014/05/11/received PY - 2014/10/14/revised PY - 2014/10/30/accepted PY - 2014/12/6/entrez PY - 2014/12/6/pubmed PY - 2015/9/22/medline KW - Gene expression KW - LRRK2 KW - Parkinson's disease KW - Peripheral blood KW - RNA-seq KW - Transcriptome SP - 1105 EP - 9 JF - Neurobiology of aging JO - Neurobiol Aging VL - 36 IS - 2 N2 - The commonest known cause of Parkinson's disease (PD) is the G2019S mutation of the LRRK2 gene, but this mutation is not sufficient for causing PD, and many carriers of the mutation never develop PD symptoms during life. Differences at the expression level of certain genes, resulting from either genetic variations or environmental interactions, might be one of the mechanisms underlying differential risks for developing both idiopathic and genetic PD. To identify the genes involved in PD pathogenesis, we compared genome-wide gene expression (RNA-seq) in peripheral blood of 20 PD patients carrying the G2019S mutation of the LRRK2 gene, 20 asymptomatic carriers of the mutation, 20 subjects with idiopathic PD, 20 controls and 7 PD patients before and after initiating dopaminergic therapy. We identified 13 common genes (ADARB2, CEACAM6, CNTNAP2, COL19A1, DEF4, DRAXIN, FCER2, HBG1, NCAPG2, PVRL2, SLC2A14, SNCA, and TCL1B) showing significant differential expression between G2019S-associated PD and asymptomatic carriers and also between idiopathic PD and controls but not between untreated and treated patients. Some of these genes are functionally involved in the processes known to be involved in PD pathogenesis, such as Akt signaling, glucose metabolism, or immunity. We consider that these genes merit further attention in future studies as potential candidate genes involved in both idiopathic and LRRK2-G2019S-associated forms of PD. SN - 1558-1497 UR - https://www.unboundmedicine.com/medline/citation/25475535/Identification_of_candidate_genes_for_Parkinson's_disease_through_blood_transcriptome_analysis_in_LRRK2_G2019S_carriers_idiopathic_cases_and_controls_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0197-4580(14)00705-2 DB - PRIME DP - Unbound Medicine ER -