Tags

Type your tag names separated by a space and hit enter

Polarity specific effects of transcranial direct current stimulation on interhemispheric inhibition.
PLoS One 2014; 9(12):e114244Plos

Abstract

Transcranial direct current stimulation (tDCS) has been used as a useful interventional brain stimulation technique to improve unilateral upper-limb motor function in healthy humans, as well as in stroke patients. Although tDCS applications are supposed to modify the interhemispheric balance between the motor cortices, the tDCS after-effects on interhemispheric interactions are still poorly understood. To address this issue, we investigated the tDCS after-effects on interhemispheric inhibition (IHI) between the primary motor cortices (M1) in healthy humans. Three types of tDCS electrode montage were tested on separate days; anodal tDCS over the right M1, cathodal tDCS over the left M1, bilateral tDCS with anode over the right M1 and cathode over the left M1. Single-pulse and paired-pulse transcranial magnetic stimulations were given to the left M1 and right M1 before and after tDCS to assess the bilateral corticospinal excitabilities and mutual direction of IHI. Regardless of the electrode montages, corticospinal excitability was increased on the same side of anodal stimulation and decreased on the same side of cathodal stimulation. However, neither unilateral tDCS changed the corticospinal excitability at the unstimulated side. Unilateral anodal tDCS increased IHI from the facilitated side M1 to the unchanged side M1, but it did not change IHI in the other direction. Unilateral cathodal tDCS suppressed IHI both from the inhibited side M1 to the unchanged side M1 and from the unchanged side M1 to the inhibited side M1. Bilateral tDCS increased IHI from the facilitated side M1 to the inhibited side M1 and attenuated IHI in the opposite direction. Sham-tDCS affected neither corticospinal excitability nor IHI. These findings indicate that tDCS produced polarity-specific after-effects on the interhemispheric interactions between M1 and that those after-effects on interhemispheric interactions were mainly dependent on whether tDCS resulted in the facilitation or inhibition of the M1 sending interhemispheric volleys.

Authors+Show Affiliations

Department of Rehabilitation for Movement Functions, Research Institute, National Rehabilitation Center for Persons with Disabilities, Tokorozawa, Japan; Japan Society for the Promotion of Science, Tokyo, Japan.Department of Rehabilitation for Movement Functions, Research Institute, National Rehabilitation Center for Persons with Disabilities, Tokorozawa, Japan; Faculty of Child Development and Education, Uekusa Gakuen University, Chiba, Japan.Department of Rehabilitation for Movement Functions, Research Institute, National Rehabilitation Center for Persons with Disabilities, Tokorozawa, Japan; Division of Functional Control Systems, Graduate School of Engineering and Science, Shibaura Institute of Technology, Saitama, Japan.Department of Rehabilitation for Movement Functions, Research Institute, National Rehabilitation Center for Persons with Disabilities, Tokorozawa, Japan.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25478912

Citation

Tazoe, Toshiki, et al. "Polarity Specific Effects of Transcranial Direct Current Stimulation On Interhemispheric Inhibition." PloS One, vol. 9, no. 12, 2014, pp. e114244.
Tazoe T, Endoh T, Kitamura T, et al. Polarity specific effects of transcranial direct current stimulation on interhemispheric inhibition. PLoS ONE. 2014;9(12):e114244.
Tazoe, T., Endoh, T., Kitamura, T., & Ogata, T. (2014). Polarity specific effects of transcranial direct current stimulation on interhemispheric inhibition. PloS One, 9(12), pp. e114244. doi:10.1371/journal.pone.0114244.
Tazoe T, et al. Polarity Specific Effects of Transcranial Direct Current Stimulation On Interhemispheric Inhibition. PLoS ONE. 2014;9(12):e114244. PubMed PMID: 25478912.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Polarity specific effects of transcranial direct current stimulation on interhemispheric inhibition. AU - Tazoe,Toshiki, AU - Endoh,Takashi, AU - Kitamura,Taku, AU - Ogata,Toru, Y1 - 2014/12/05/ PY - 2014/07/24/received PY - 2014/11/05/accepted PY - 2014/12/6/entrez PY - 2014/12/6/pubmed PY - 2015/7/30/medline SP - e114244 EP - e114244 JF - PloS one JO - PLoS ONE VL - 9 IS - 12 N2 - Transcranial direct current stimulation (tDCS) has been used as a useful interventional brain stimulation technique to improve unilateral upper-limb motor function in healthy humans, as well as in stroke patients. Although tDCS applications are supposed to modify the interhemispheric balance between the motor cortices, the tDCS after-effects on interhemispheric interactions are still poorly understood. To address this issue, we investigated the tDCS after-effects on interhemispheric inhibition (IHI) between the primary motor cortices (M1) in healthy humans. Three types of tDCS electrode montage were tested on separate days; anodal tDCS over the right M1, cathodal tDCS over the left M1, bilateral tDCS with anode over the right M1 and cathode over the left M1. Single-pulse and paired-pulse transcranial magnetic stimulations were given to the left M1 and right M1 before and after tDCS to assess the bilateral corticospinal excitabilities and mutual direction of IHI. Regardless of the electrode montages, corticospinal excitability was increased on the same side of anodal stimulation and decreased on the same side of cathodal stimulation. However, neither unilateral tDCS changed the corticospinal excitability at the unstimulated side. Unilateral anodal tDCS increased IHI from the facilitated side M1 to the unchanged side M1, but it did not change IHI in the other direction. Unilateral cathodal tDCS suppressed IHI both from the inhibited side M1 to the unchanged side M1 and from the unchanged side M1 to the inhibited side M1. Bilateral tDCS increased IHI from the facilitated side M1 to the inhibited side M1 and attenuated IHI in the opposite direction. Sham-tDCS affected neither corticospinal excitability nor IHI. These findings indicate that tDCS produced polarity-specific after-effects on the interhemispheric interactions between M1 and that those after-effects on interhemispheric interactions were mainly dependent on whether tDCS resulted in the facilitation or inhibition of the M1 sending interhemispheric volleys. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/25478912/Polarity_specific_effects_of_transcranial_direct_current_stimulation_on_interhemispheric_inhibition_ L2 - http://dx.plos.org/10.1371/journal.pone.0114244 DB - PRIME DP - Unbound Medicine ER -