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Improved longitudinal [(18)F]-AV45 amyloid PET by white matter reference and VOI-based partial volume effect correction.
Neuroimage. 2015 Mar; 108:450-9.N

Abstract

Amyloid positron-emission-tomography (PET) offers an important research and diagnostic tool for investigating Alzheimer's disease (AD). The majority of amyloid PET studies have used the cerebellum as a reference region, and clinical studies have not accounted for atrophy-based partial volume effects (PVE). Longitudinal studies using cerebellum as reference tissue have revealed only small mean increases and high inter-subject variability in amyloid binding. We aimed to test the effects of different reference regions and PVE-correction (PVEC) on the discriminatory power and longitudinal performance of amyloid PET. We analyzed [(18)F]-AV45 PET and T1-weighted MRI data of 962 subjects at baseline and two-year follow-up data of 258 subjects. Cortical composite volume-of-interest (VOI) values (COMP) for tracer uptake were generated using either full brain atlas VOIs, gray matter segmented VOIs or gray matter segmented VOIs after VOI-based PVEC. Standard-uptake-value ratios (SUVR) were calculated by scaling the COMP values to uptake in cerebellum (SUVRCBL), brainstem (SUVRBST) or white matter (SUVRWM). Mean SUV, SUVR, and changes after PVEC were compared at baseline between diagnostic groups of healthy controls (HC; N=316), mild cognitive impairment (MCI; N=483) and AD (N=163). Receiver operating characteristics (ROC) were calculated for the discriminations between HC, MCI and AD, and expressed as area under the curve (AUC). Finally, the longitudinal [(18)F]-AV45-PET data were used to analyze the impact of quantitation procedures on apparent changes in amyloid load over time. Reference region SUV was most constant between diagnosis groups for the white matter. PVEC led to decreases of COMP-SUV in HC (-18%) and MCI (-10%), but increases in AD (+7%). Highest AUCs were found when using PVEC with white matter scaling for the contrast between HC/AD (0.907) or with brainstem scaling for the contrast between HC/MCI (0.658). Longitudinal increases were greatest in all diagnosis groups with application of PVEC, and inter-subject variability was lowest for the white matter reference. Thus, discriminatory power of [(18)F]-AV45-PET was improved by use of a VOI-based PVEC and white matter or brainstem rather than cerebellum reference region. Detection of longitudinal amyloid increases was optimized with PVEC and white matter reference tissue.

Authors+Show Affiliations

Dept. of Nuclear Medicine, University of Munich, Germany.Dept. of Nuclear Medicine, University of Munich, Germany.Dept. of Nuclear Medicine, University of Munich, Germany.Dept. of Nuclear Medicine, University of Munich, Germany.Dept. of Nuclear Medicine, University of Munich, Germany.MNI, New Haven, USA.Dept. of Nuclear Medicine, University of Munich, Germany. Electronic address: axel.rominger@med.uni-muenchen.de.No affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

25482269

Citation

Brendel, Matthias, et al. "Improved Longitudinal [(18)F]-AV45 Amyloid PET By White Matter Reference and VOI-based Partial Volume Effect Correction." NeuroImage, vol. 108, 2015, pp. 450-9.
Brendel M, Högenauer M, Delker A, et al. Improved longitudinal [(18)F]-AV45 amyloid PET by white matter reference and VOI-based partial volume effect correction. Neuroimage. 2015;108:450-9.
Brendel, M., Högenauer, M., Delker, A., Sauerbeck, J., Bartenstein, P., Seibyl, J., & Rominger, A. (2015). Improved longitudinal [(18)F]-AV45 amyloid PET by white matter reference and VOI-based partial volume effect correction. NeuroImage, 108, 450-9. https://doi.org/10.1016/j.neuroimage.2014.11.055
Brendel M, et al. Improved Longitudinal [(18)F]-AV45 Amyloid PET By White Matter Reference and VOI-based Partial Volume Effect Correction. Neuroimage. 2015;108:450-9. PubMed PMID: 25482269.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Improved longitudinal [(18)F]-AV45 amyloid PET by white matter reference and VOI-based partial volume effect correction. AU - Brendel,Matthias, AU - Högenauer,Marcus, AU - Delker,Andreas, AU - Sauerbeck,Julia, AU - Bartenstein,Peter, AU - Seibyl,John, AU - Rominger,Axel, AU - ,, Y1 - 2014/12/04/ PY - 2014/10/14/received PY - 2014/11/20/revised PY - 2014/11/26/accepted PY - 2014/12/9/entrez PY - 2014/12/9/pubmed PY - 2016/1/29/medline KW - (18)F-AV45-PET KW - Alzheimer's disease KW - Partial volume effect correction KW - Reference region SP - 450 EP - 9 JF - NeuroImage JO - Neuroimage VL - 108 N2 - Amyloid positron-emission-tomography (PET) offers an important research and diagnostic tool for investigating Alzheimer's disease (AD). The majority of amyloid PET studies have used the cerebellum as a reference region, and clinical studies have not accounted for atrophy-based partial volume effects (PVE). Longitudinal studies using cerebellum as reference tissue have revealed only small mean increases and high inter-subject variability in amyloid binding. We aimed to test the effects of different reference regions and PVE-correction (PVEC) on the discriminatory power and longitudinal performance of amyloid PET. We analyzed [(18)F]-AV45 PET and T1-weighted MRI data of 962 subjects at baseline and two-year follow-up data of 258 subjects. Cortical composite volume-of-interest (VOI) values (COMP) for tracer uptake were generated using either full brain atlas VOIs, gray matter segmented VOIs or gray matter segmented VOIs after VOI-based PVEC. Standard-uptake-value ratios (SUVR) were calculated by scaling the COMP values to uptake in cerebellum (SUVRCBL), brainstem (SUVRBST) or white matter (SUVRWM). Mean SUV, SUVR, and changes after PVEC were compared at baseline between diagnostic groups of healthy controls (HC; N=316), mild cognitive impairment (MCI; N=483) and AD (N=163). Receiver operating characteristics (ROC) were calculated for the discriminations between HC, MCI and AD, and expressed as area under the curve (AUC). Finally, the longitudinal [(18)F]-AV45-PET data were used to analyze the impact of quantitation procedures on apparent changes in amyloid load over time. Reference region SUV was most constant between diagnosis groups for the white matter. PVEC led to decreases of COMP-SUV in HC (-18%) and MCI (-10%), but increases in AD (+7%). Highest AUCs were found when using PVEC with white matter scaling for the contrast between HC/AD (0.907) or with brainstem scaling for the contrast between HC/MCI (0.658). Longitudinal increases were greatest in all diagnosis groups with application of PVEC, and inter-subject variability was lowest for the white matter reference. Thus, discriminatory power of [(18)F]-AV45-PET was improved by use of a VOI-based PVEC and white matter or brainstem rather than cerebellum reference region. Detection of longitudinal amyloid increases was optimized with PVEC and white matter reference tissue. SN - 1095-9572 UR - https://www.unboundmedicine.com/medline/citation/25482269/Improved_longitudinal_[_18_F]_AV45_amyloid_PET_by_white_matter_reference_and_VOI_based_partial_volume_effect_correction_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1053-8119(14)00985-9 DB - PRIME DP - Unbound Medicine ER -