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Demographic and clinical features of systemic sclerosis patients with anti-RNA polymerase III antibodies.
J Dermatol. 2015 Feb; 42(2):189-92.JD

Abstract

Anti-RNA polymerase III antibody (RNAP) is primarily detected in diffuse cutaneous type systemic sclerosis (dcSSc) patients and strongly associated with renal crisis. Additionally, there has been increasing evidence that cancer in SSc patients is associated with RNAP. The aim of this study was to examine the demographic and clinical features of SSc patients with RNAP. Among 246 SSc patients, 5.7% were positive for RNAP, 20.7% were positive for anti-topoisomerase I antibody (Topo I) alone and 39.4% were positive for anticentromere antibody (ACA) alone. The modified Rodnan total skin score (mRTSS) in SSc patients with RNAP (19.1 ± 2.6) was significantly higher than those in SSc patients with Topo I (11.5 ± 1.1) and patients with ACA (4.4 ± 0.4). Furthermore, among SSc patients with RNAP, the levels of RNAP were positively correlated with mRTSS. Renal crisis is also significantly more prevalent in SSc patients with RNAP than patients without RNAP. Male sex, dcSSc subtype, digital vasculopathy, including digital ulcers and acro-osteolysis, interstitial lung disease and rheumatoid arthritis complications were prevalent in SSc patients with RNAP and patients with Topo-I. Primary biliary cirrhosis and Sjögren's syndrome were more in SSc patients with RNAP and patients with ACA compared with patients with Topo 1. No significant difference in the frequency of complications, including Raynaud's phenomenon, pulmonary artery hypertension and malignancy was observed between the three groups. Thus, measurement of RNAP in SSc patients is useful for the diagnosis and risk stratification of severe manifestation, such as renal crisis and severe skin sclerosis.

Authors+Show Affiliations

Department of Dermatology, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25483258

Citation

Motegi, Sei-Ichiro, et al. "Demographic and Clinical Features of Systemic Sclerosis Patients With anti-RNA Polymerase III Antibodies." The Journal of Dermatology, vol. 42, no. 2, 2015, pp. 189-92.
Motegi S, Toki S, Yamada K, et al. Demographic and clinical features of systemic sclerosis patients with anti-RNA polymerase III antibodies. J Dermatol. 2015;42(2):189-92.
Motegi, S., Toki, S., Yamada, K., Uchiyama, A., & Ishikawa, O. (2015). Demographic and clinical features of systemic sclerosis patients with anti-RNA polymerase III antibodies. The Journal of Dermatology, 42(2), 189-92. https://doi.org/10.1111/1346-8138.12722
Motegi S, et al. Demographic and Clinical Features of Systemic Sclerosis Patients With anti-RNA Polymerase III Antibodies. J Dermatol. 2015;42(2):189-92. PubMed PMID: 25483258.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Demographic and clinical features of systemic sclerosis patients with anti-RNA polymerase III antibodies. AU - Motegi,Sei-Ichiro, AU - Toki,Sayaka, AU - Yamada,Kazuya, AU - Uchiyama,Akihiko, AU - Ishikawa,Osamu, Y1 - 2014/12/06/ PY - 2014/09/11/received PY - 2014/10/16/accepted PY - 2014/12/9/entrez PY - 2014/12/9/pubmed PY - 2016/12/15/medline KW - anti-RNA polymerase III antibody KW - autoantibody KW - malignancy KW - renal crisis KW - systemic sclerosis SP - 189 EP - 92 JF - The Journal of dermatology JO - J. Dermatol. VL - 42 IS - 2 N2 - Anti-RNA polymerase III antibody (RNAP) is primarily detected in diffuse cutaneous type systemic sclerosis (dcSSc) patients and strongly associated with renal crisis. Additionally, there has been increasing evidence that cancer in SSc patients is associated with RNAP. The aim of this study was to examine the demographic and clinical features of SSc patients with RNAP. Among 246 SSc patients, 5.7% were positive for RNAP, 20.7% were positive for anti-topoisomerase I antibody (Topo I) alone and 39.4% were positive for anticentromere antibody (ACA) alone. The modified Rodnan total skin score (mRTSS) in SSc patients with RNAP (19.1 ± 2.6) was significantly higher than those in SSc patients with Topo I (11.5 ± 1.1) and patients with ACA (4.4 ± 0.4). Furthermore, among SSc patients with RNAP, the levels of RNAP were positively correlated with mRTSS. Renal crisis is also significantly more prevalent in SSc patients with RNAP than patients without RNAP. Male sex, dcSSc subtype, digital vasculopathy, including digital ulcers and acro-osteolysis, interstitial lung disease and rheumatoid arthritis complications were prevalent in SSc patients with RNAP and patients with Topo-I. Primary biliary cirrhosis and Sjögren's syndrome were more in SSc patients with RNAP and patients with ACA compared with patients with Topo 1. No significant difference in the frequency of complications, including Raynaud's phenomenon, pulmonary artery hypertension and malignancy was observed between the three groups. Thus, measurement of RNAP in SSc patients is useful for the diagnosis and risk stratification of severe manifestation, such as renal crisis and severe skin sclerosis. SN - 1346-8138 UR - https://www.unboundmedicine.com/medline/citation/25483258/Demographic_and_clinical_features_of_systemic_sclerosis_patients_with_anti_RNA_polymerase_III_antibodies_ L2 - https://doi.org/10.1111/1346-8138.12722 DB - PRIME DP - Unbound Medicine ER -