TY - JOUR T1 - Nine μg intradermal influenza vaccine and 15 μg intramuscular influenza vaccine induce similar cellular and humoral immune responses in adults. AU - Nougarede,Nolwenn, AU - Bisceglia,Hélène, AU - Rozières,Aurore, AU - Goujon,Catherine, AU - Boudet,Florence, AU - Laurent,Philippe, AU - Vanbervliet,Beatrice, AU - Rodet,Karen, AU - Hennino,Ana, AU - Nicolas,Jean-François, PY - 2014/12/9/entrez PY - 2014/12/9/pubmed PY - 2016/5/18/medline KW - BSA, bovine serum albumin KW - CHMP, Committee for Medicinal Products for Human Use KW - ELISA, enzyme-linked immunosorbent assay KW - ELISPOT, enzyme-linked immunospot KW - HI, hemagglutination inhibition KW - ID, intradermal KW - IM, intramuscular KW - Ig, immunoglobulin KW - PBMC, peripheral blood mononuclear cells KW - PBS, phosphate-buffered saline KW - adult KW - immunogenicity KW - intradermal influenza vaccine KW - intramuscular vaccination KW - trivalent influenza vaccine SP - 2713 EP - 20 JF - Human vaccines & immunotherapeutics JO - Hum Vaccin Immunother VL - 10 IS - 9 N2 - Intanza® 9 μg (Sanofi Pasteur), a trivalent split-virion vaccine administered by intradermal (ID) injection, was approved in Europe in 2009 for the prevention of seasonal influenza in adults 18 to 59 years. Here, we examined the immune responses induced in adults by the ID 9 μg vaccine and the standard trivalent intramuscular (IM) vaccine (Vaxigrip® 15 μg, Sanofi Pasteur). This trial was a randomized, controlled, single-center, open-label study in healthy adults 18 to 40 years of age during the 2007/8 influenza season. Subjects received a single vaccination with the ID 9 μg (n=38) or IM 15 μg (n=42) vaccine. Serum, saliva, and peripheral blood mononuclear cells were collected up to 180 days post-vaccination. Geometric mean hemagglutination inhibition titers, seroprotection rates, seroconversion rates, and pre-vaccination-to-post-vaccination ratios of geometric mean hemagglutination inhibition titers did not differ between the two vaccines. Compared with pre-vaccination, the vaccines induced similar increases in vaccine-specific circulating B cells at day 7 but did not induce significant increases in vaccine-specific memory B cells at day 180. Cell-mediated immunity to all three vaccine strains, measured in peripheral blood mononuclear cells, was high at baseline and not increased by either vaccine. Neither vaccine induced a mucosal immune response. These results show that the humoral and cellular immune responses to the ID 9 μg vaccine are similar to those to the standard IM 15 μg vaccine. SN - 2164-554X UR - https://www.unboundmedicine.com/medline/citation/25483667/Nine_μg_intradermal_influenza_vaccine_and_15_μg_intramuscular_influenza_vaccine_induce_similar_cellular_and_humoral_immune_responses_in_adults_ DB - PRIME DP - Unbound Medicine ER -