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Uterine and umbilical artery Doppler at 28 weeks for predicting adverse pregnancy outcomes in women with abnormal uterine artery Doppler findings in the early second trimester.
Prenat Diagn 2015; 35(3):294-8PD

Abstract

OBJECTIVE

The objective of this study was to determine the contribution of uterine (UtA) and umbilical arteries (UA) Doppler examination at 28 weeks to predict adverse pregnancy outcomes in women who had increased resistance in UtA in the early second trimester.

METHODS

Women with UtA mean pulsatility index (PI) above the 95th centile at 19-22 weeks of gestation were offered a growth scan including Doppler examination of UtA and UA at 28 weeks. Adverse pregnancy outcomes included small for gestational age (SGA), defined as birth weight below the tenth centile, preeclampsia (PE) and early-onset PE (PE before 34 weeks).

RESULTS

We studied 266 pregnant women with elevated PI in the UtAs in the second trimester and ultrasound reassessment at 28 weeks. UtA PI >95th centile at 28 weeks was associated with subsequent PE [odds ratio (OR): 10.0, 95% CI: 2.3-43.5], early-onset PE (OR: 57.7, 95% CI: 3.8-87.6) and SGA less than the tenth centile (OR: 5.5, 2.2-13.9). UA PI >95th centile at 28 weeks was not significantly associated with any adverse outcome.

CONCLUSIONS

In women with abnormal UtA Doppler in the early second trimester scan, persistence of elevated UtA PI, but not abnormal UA PI, is associated with adverse pregnancy outcomes including PE, early-onset PE and SGA. © 2014 John Wiley & Sons, Ltd.

Authors+Show Affiliations

Fetal Medicine Unit, Instituto Nacional Materno Perinatal, Lima, Peru.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25483940

Citation

Ventura, Walter, et al. "Uterine and Umbilical Artery Doppler at 28 Weeks for Predicting Adverse Pregnancy Outcomes in Women With Abnormal Uterine Artery Doppler Findings in the Early Second Trimester." Prenatal Diagnosis, vol. 35, no. 3, 2015, pp. 294-8.
Ventura W, De Paco Matallana C, Prieto-Sanchez MT, et al. Uterine and umbilical artery Doppler at 28 weeks for predicting adverse pregnancy outcomes in women with abnormal uterine artery Doppler findings in the early second trimester. Prenat Diagn. 2015;35(3):294-8.
Ventura, W., De Paco Matallana, C., Prieto-Sanchez, M. T., Macizo, M. I., Pertegal, M., Nieto, A., & Delgado, J. L. (2015). Uterine and umbilical artery Doppler at 28 weeks for predicting adverse pregnancy outcomes in women with abnormal uterine artery Doppler findings in the early second trimester. Prenatal Diagnosis, 35(3), pp. 294-8. doi:10.1002/pd.4542.
Ventura W, et al. Uterine and Umbilical Artery Doppler at 28 Weeks for Predicting Adverse Pregnancy Outcomes in Women With Abnormal Uterine Artery Doppler Findings in the Early Second Trimester. Prenat Diagn. 2015;35(3):294-8. PubMed PMID: 25483940.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Uterine and umbilical artery Doppler at 28 weeks for predicting adverse pregnancy outcomes in women with abnormal uterine artery Doppler findings in the early second trimester. AU - Ventura,Walter, AU - De Paco Matallana,Catalina, AU - Prieto-Sanchez,Maria Teresa, AU - Macizo,María Isabel, AU - Pertegal,Miriam, AU - Nieto,Aníbal, AU - Delgado,Juan L, Y1 - 2015/01/05/ PY - 2014/07/28/received PY - 2014/11/24/revised PY - 2014/11/26/accepted PY - 2014/12/9/entrez PY - 2014/12/9/pubmed PY - 2015/12/15/medline SP - 294 EP - 8 JF - Prenatal diagnosis JO - Prenat. Diagn. VL - 35 IS - 3 N2 - OBJECTIVE: The objective of this study was to determine the contribution of uterine (UtA) and umbilical arteries (UA) Doppler examination at 28 weeks to predict adverse pregnancy outcomes in women who had increased resistance in UtA in the early second trimester. METHODS: Women with UtA mean pulsatility index (PI) above the 95th centile at 19-22 weeks of gestation were offered a growth scan including Doppler examination of UtA and UA at 28 weeks. Adverse pregnancy outcomes included small for gestational age (SGA), defined as birth weight below the tenth centile, preeclampsia (PE) and early-onset PE (PE before 34 weeks). RESULTS: We studied 266 pregnant women with elevated PI in the UtAs in the second trimester and ultrasound reassessment at 28 weeks. UtA PI >95th centile at 28 weeks was associated with subsequent PE [odds ratio (OR): 10.0, 95% CI: 2.3-43.5], early-onset PE (OR: 57.7, 95% CI: 3.8-87.6) and SGA less than the tenth centile (OR: 5.5, 2.2-13.9). UA PI >95th centile at 28 weeks was not significantly associated with any adverse outcome. CONCLUSIONS: In women with abnormal UtA Doppler in the early second trimester scan, persistence of elevated UtA PI, but not abnormal UA PI, is associated with adverse pregnancy outcomes including PE, early-onset PE and SGA. © 2014 John Wiley & Sons, Ltd. SN - 1097-0223 UR - https://www.unboundmedicine.com/medline/citation/25483940/Uterine_and_umbilical_artery_Doppler_at_28_weeks_for_predicting_adverse_pregnancy_outcomes_in_women_with_abnormal_uterine_artery_Doppler_findings_in_the_early_second_trimester_ L2 - https://doi.org/10.1002/pd.4542 DB - PRIME DP - Unbound Medicine ER -