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Poly(3,4-ethylenedioxythiophene):dextran sulfate (PEDOT:DS) - a highly processable conductive organic biopolymer.
Acta Biomater 2015; 14:33-42AB

Abstract

A novel water-dispersible conducting polymer analogous to poly(3,4-dioxythiophene):polystyrene sulfonate (PEDOT:PSS) has been chemically synthesized in a single reaction in high yield. PEDOT:DS, a new member of the polythiophene family, is composed of a complex between PEDOT and the sulfonated polysaccharide polyanion dextran sulfate. Drop-cast films of aqueous suspensions of the material display a native conductivity of up to 7 ± 1 S cm(-1), increasing to 20 ± 2 S cm(-1) after treatment with ethylene glycol and thermal annealing. Mass ratios of the precursors NaDS and EDOT were varied from 5:1 to 2:1 and a decrease in the NaDS:EDOT ratio produces tougher, less hygroscopic films of higher conductivity. Ultraviolet-visible spectroelectrochemistry yields spectra typical of PEDOT complexes. Cyclic voltammetry reveals that PEDOT:DS is electrochemically active from -1.0 to 0.8 V vs. Ag/Ag(+) in acetonitrile, with similar characteristics to PEDOT:PSS. Water dispersions of PEDOT:DS are successfully processed by drop casting, spray coating, inkjet printing and extrusion printing. Furthermore, laser etching of dried films allows the creation of patterns with excellent definition. To assess the cytotoxicity of PEDOT:DS, L-929 cells were cultured with a polymer complex concentration range of 0.002 to 0.2 g l(-1) in cell culture medium. No significant difference is found between the proliferation rates of L-929 cells exposed to PEDOT:DS and those in plain medium after 96h. However, PEDOT:PSS shows around 25% less cell growth after 4 days, even at the lowest concentration. Taken together, these results suggest PEDOT:DS has exceptional potential as an electromaterial for the biointerface.

Authors+Show Affiliations

Intelligent Polymer Research Institute, ARC Centre of Excellence for Electromaterials Science, AIIM Facility, University of Wollongong, Wollongong, NSW 2522, Australia.Intelligent Polymer Research Institute, ARC Centre of Excellence for Electromaterials Science, AIIM Facility, University of Wollongong, Wollongong, NSW 2522, Australia.Intelligent Polymer Research Institute, ARC Centre of Excellence for Electromaterials Science, AIIM Facility, University of Wollongong, Wollongong, NSW 2522, Australia.Intelligent Polymer Research Institute, ARC Centre of Excellence for Electromaterials Science, AIIM Facility, University of Wollongong, Wollongong, NSW 2522, Australia.Intelligent Polymer Research Institute, ARC Centre of Excellence for Electromaterials Science, AIIM Facility, University of Wollongong, Wollongong, NSW 2522, Australia.Intelligent Polymer Research Institute, ARC Centre of Excellence for Electromaterials Science, AIIM Facility, University of Wollongong, Wollongong, NSW 2522, Australia.Intelligent Polymer Research Institute, ARC Centre of Excellence for Electromaterials Science, AIIM Facility, University of Wollongong, Wollongong, NSW 2522, Australia.Intelligent Polymer Research Institute, ARC Centre of Excellence for Electromaterials Science, AIIM Facility, University of Wollongong, Wollongong, NSW 2522, Australia; Soft Materials Group, School of Chemistry, University of Wollongong, Wollongong, NSW 2522, Australia.Intelligent Polymer Research Institute, ARC Centre of Excellence for Electromaterials Science, AIIM Facility, University of Wollongong, Wollongong, NSW 2522, Australia. Electronic address: gwallace@uow.edu.au.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25484333

Citation

Harman, David G., et al. "Poly(3,4-ethylenedioxythiophene):dextran Sulfate (PEDOT:DS) - a Highly Processable Conductive Organic Biopolymer." Acta Biomaterialia, vol. 14, 2015, pp. 33-42.
Harman DG, Gorkin R, Stevens L, et al. Poly(3,4-ethylenedioxythiophene):dextran sulfate (PEDOT:DS) - a highly processable conductive organic biopolymer. Acta Biomater. 2015;14:33-42.
Harman, D. G., Gorkin, R., Stevens, L., Thompson, B., Wagner, K., Weng, B., ... Wallace, G. G. (2015). Poly(3,4-ethylenedioxythiophene):dextran sulfate (PEDOT:DS) - a highly processable conductive organic biopolymer. Acta Biomaterialia, 14, pp. 33-42. doi:10.1016/j.actbio.2014.11.049.
Harman DG, et al. Poly(3,4-ethylenedioxythiophene):dextran Sulfate (PEDOT:DS) - a Highly Processable Conductive Organic Biopolymer. Acta Biomater. 2015;14:33-42. PubMed PMID: 25484333.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Poly(3,4-ethylenedioxythiophene):dextran sulfate (PEDOT:DS) - a highly processable conductive organic biopolymer. AU - Harman,David G, AU - Gorkin,Robert,3rd AU - Stevens,Leo, AU - Thompson,Brianna, AU - Wagner,Klaudia, AU - Weng,Bo, AU - Chung,Johnson H Y, AU - In Het Panhuis,Marc, AU - Wallace,Gordon G, Y1 - 2014/12/04/ PY - 2014/07/08/received PY - 2014/11/24/revised PY - 2014/11/26/accepted PY - 2014/12/9/entrez PY - 2014/12/9/pubmed PY - 2015/10/3/medline KW - Bioelectronics KW - Dextran sulfate KW - Electromaterial KW - Organic electronics KW - PEDOT SP - 33 EP - 42 JF - Acta biomaterialia JO - Acta Biomater VL - 14 N2 - A novel water-dispersible conducting polymer analogous to poly(3,4-dioxythiophene):polystyrene sulfonate (PEDOT:PSS) has been chemically synthesized in a single reaction in high yield. PEDOT:DS, a new member of the polythiophene family, is composed of a complex between PEDOT and the sulfonated polysaccharide polyanion dextran sulfate. Drop-cast films of aqueous suspensions of the material display a native conductivity of up to 7 ± 1 S cm(-1), increasing to 20 ± 2 S cm(-1) after treatment with ethylene glycol and thermal annealing. Mass ratios of the precursors NaDS and EDOT were varied from 5:1 to 2:1 and a decrease in the NaDS:EDOT ratio produces tougher, less hygroscopic films of higher conductivity. Ultraviolet-visible spectroelectrochemistry yields spectra typical of PEDOT complexes. Cyclic voltammetry reveals that PEDOT:DS is electrochemically active from -1.0 to 0.8 V vs. Ag/Ag(+) in acetonitrile, with similar characteristics to PEDOT:PSS. Water dispersions of PEDOT:DS are successfully processed by drop casting, spray coating, inkjet printing and extrusion printing. Furthermore, laser etching of dried films allows the creation of patterns with excellent definition. To assess the cytotoxicity of PEDOT:DS, L-929 cells were cultured with a polymer complex concentration range of 0.002 to 0.2 g l(-1) in cell culture medium. No significant difference is found between the proliferation rates of L-929 cells exposed to PEDOT:DS and those in plain medium after 96h. However, PEDOT:PSS shows around 25% less cell growth after 4 days, even at the lowest concentration. Taken together, these results suggest PEDOT:DS has exceptional potential as an electromaterial for the biointerface. SN - 1878-7568 UR - https://www.unboundmedicine.com/medline/citation/25484333/Poly_34_ethylenedioxythiophene_:dextran_sulfate__PEDOT:DS____a_highly_processable_conductive_organic_biopolymer_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1742-7061(14)00552-2 DB - PRIME DP - Unbound Medicine ER -