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Two new triterpenoid saponins from rhizome of Anemone amurensis.
J Asian Nat Prod Res. 2015; 17(2):132-7.JA

Abstract

Two new triterpenoid saponins were isolated from the 70% ethanol extract of the rhizome of Anemone amurensis, they are oleanolic acid 28-O-β-d-glucopyranosyl-(1 → 3)-α-l-rhamnopyranosyl-(1 → 4)-β-d-glucopyranosyl-(1 → 6)-β-d-glucopyranosyl ester (1) and 23,27-dihydroxy oleanolic acid 3-O-α-l-arabinopyranoside (2). The structures of 1 and 2 were elucidated on the basis of chemical and spectral analysis, including 1D and 2D NMR data and HR-ESI-MS. Compounds 1 and 2 were tested for cytotoxicities against three human cancer cell lines (A549, Hep-G2, and MCF-7). Compound 1 showed potent cytotoxicity with IC50 values of 34.76, 41.17, and 28.92 μM, respectively, while compound 2 with IC50>100 μM.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Lv CN
a School of Traditional Chinese Materia Medica , Shenyang Pharmaceutical University , Shenyang 110016 , China.
Fan L
No affiliation info available
Wang J
No affiliation info available
Qin RL
No affiliation info available
Xu TY
No affiliation info available
Lei TL
No affiliation info available
Lu JC
No affiliation info available

MeSH

AnemoneAntineoplastic Agents, PhytogenicDrug Screening Assays, AntitumorDrugs, Chinese HerbalHep G2 CellsHumansMCF-7 CellsMolecular StructureNuclear Magnetic Resonance, BiomolecularOleanolic AcidRhizomeSaponins

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25486328

Citation

Lv, Chong-Ning, et al. "Two New Triterpenoid Saponins From Rhizome of Anemone Amurensis." Journal of Asian Natural Products Research, vol. 17, no. 2, 2015, pp. 132-7.
Lv CN, Fan L, Wang J, et al. Two new triterpenoid saponins from rhizome of Anemone amurensis. J Asian Nat Prod Res. 2015;17(2):132-7.
Lv, C. N., Fan, L., Wang, J., Qin, R. L., Xu, T. Y., Lei, T. L., & Lu, J. C. (2015). Two new triterpenoid saponins from rhizome of Anemone amurensis. Journal of Asian Natural Products Research, 17(2), 132-7. https://doi.org/10.1080/10286020.2014.983091
Lv CN, et al. Two New Triterpenoid Saponins From Rhizome of Anemone Amurensis. J Asian Nat Prod Res. 2015;17(2):132-7. PubMed PMID: 25486328.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Two new triterpenoid saponins from rhizome of Anemone amurensis. AU - Lv,Chong-Ning, AU - Fan,Li, AU - Wang,Jing, AU - Qin,Ru-Lan, AU - Xu,Tan-Ye, AU - Lei,Tian-Li, AU - Lu,Jin-Cai, Y1 - 2014/12/08/ PY - 2014/12/9/entrez PY - 2014/12/9/pubmed PY - 2015/6/19/medline KW - Anemone amurensis KW - NMR KW - cytotoxic activity KW - triterpenoid saponins SP - 132 EP - 7 JF - Journal of Asian natural products research JO - J Asian Nat Prod Res VL - 17 IS - 2 N2 - Two new triterpenoid saponins were isolated from the 70% ethanol extract of the rhizome of Anemone amurensis, they are oleanolic acid 28-O-β-d-glucopyranosyl-(1 → 3)-α-l-rhamnopyranosyl-(1 → 4)-β-d-glucopyranosyl-(1 → 6)-β-d-glucopyranosyl ester (1) and 23,27-dihydroxy oleanolic acid 3-O-α-l-arabinopyranoside (2). The structures of 1 and 2 were elucidated on the basis of chemical and spectral analysis, including 1D and 2D NMR data and HR-ESI-MS. Compounds 1 and 2 were tested for cytotoxicities against three human cancer cell lines (A549, Hep-G2, and MCF-7). Compound 1 showed potent cytotoxicity with IC50 values of 34.76, 41.17, and 28.92 μM, respectively, while compound 2 with IC50>100 μM. SN - 1477-2213 UR - https://www.unboundmedicine.com/medline/citation/25486328/Two_new_triterpenoid_saponins_from_rhizome_of_Anemone_amurensis_ DB - PRIME DP - Unbound Medicine ER -