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Serum CYFRA 21-1 in Biliary Tract Cancers: A Reliable Biomarker for Gallbladder Carcinoma and Intrahepatic Cholangiocarcinoma.
Dig Dis Sci. 2015 May; 60(5):1273-83.DD

Abstract

BACKGROUND

Biliary tract cancers encompass gallbladder carcinoma, and intrahepatic, perihilar and distal cholangiocarcinoma. Upregulated serum CYFRA 21-1 has been reported in intrahepatic cholangiocarcinoma.

AIMS

The present study aimed to explore the clinical significance of serum CYFRA 21-1 in all biliary tract cancer subtypes.

METHODS

Serum CYFRA 21-1, carbohydrate antigen 19-9 and carcinoembryonic antigen were quantitated preoperatively, postoperatively and during follow-up in 134 malignant and 52 benign patients. Receiver operator characteristic curves of biomarkers were analyzed. Level of CYFRA 21-1 was correlated with patients' clinicopathological features and follow-up data.

RESULTS

CYFRA 21-1 was significantly upregulated in biliary malignancies, and expressional difference existed between these subtypes. Based on the maximal Youden's index, cutoff values were selected (ng/mL): 2.61 for biliary tract cancers (sensitivity 74.6 % and specificity 84.6 %); 3.27 for intrahepatic cholangiocarcinoma (75.6 and 96.2 %) and gallbladder carcinoma (93.7 and 96.2 %); 2.27 for perihilar cholangiocarcinoma (71.0 and 71.2 %); and 2.61 for distal cholangiocarcinoma (63.3 and 84.6 %). CYFRA 21-1 showed better diagnostic performance than other biomarkers in gallbladder carcinoma and intrahepatic cholangiocarcinoma; its performance was not inferior to that of the combination of these three biomarkers and declined after curative resection and re-elevated when tumor recurred, which was correlated with tumor aggressiveness and TNM stage; it was an independent predictor for 1-year recurrence-free survival and overall survival on multivariate analysis.

CONCLUSION

Serum CYFRA 21-1 represents a reliable biomarker for gallbladder carcinoma and intrahepatic cholangiocarcinoma.

Authors+Show Affiliations

Department of Hepatobiliary Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25487191

Citation

Huang, Li, et al. "Serum CYFRA 21-1 in Biliary Tract Cancers: a Reliable Biomarker for Gallbladder Carcinoma and Intrahepatic Cholangiocarcinoma." Digestive Diseases and Sciences, vol. 60, no. 5, 2015, pp. 1273-83.
Huang L, Chen W, Liang P, et al. Serum CYFRA 21-1 in Biliary Tract Cancers: A Reliable Biomarker for Gallbladder Carcinoma and Intrahepatic Cholangiocarcinoma. Dig Dis Sci. 2015;60(5):1273-83.
Huang, L., Chen, W., Liang, P., Hu, W., Zhang, K., Shen, S., Chen, J., Zhang, Z., Chen, B., Han, Y., Meng, F., DeMorrow, S., Yin, X., Lai, J., & Liang, L. (2015). Serum CYFRA 21-1 in Biliary Tract Cancers: A Reliable Biomarker for Gallbladder Carcinoma and Intrahepatic Cholangiocarcinoma. Digestive Diseases and Sciences, 60(5), 1273-83. https://doi.org/10.1007/s10620-014-3472-0
Huang L, et al. Serum CYFRA 21-1 in Biliary Tract Cancers: a Reliable Biomarker for Gallbladder Carcinoma and Intrahepatic Cholangiocarcinoma. Dig Dis Sci. 2015;60(5):1273-83. PubMed PMID: 25487191.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum CYFRA 21-1 in Biliary Tract Cancers: A Reliable Biomarker for Gallbladder Carcinoma and Intrahepatic Cholangiocarcinoma. AU - Huang,Li, AU - Chen,Wei, AU - Liang,Peiwen, AU - Hu,Wenjie, AU - Zhang,Kunsong, AU - Shen,Shunli, AU - Chen,Jiancong, AU - Zhang,Zhaohui, AU - Chen,Bin, AU - Han,Yuyan, AU - Meng,Fanyin, AU - DeMorrow,Sharon, AU - Yin,Xiaoyu, AU - Lai,Jiaming, AU - Liang,Lijian, Y1 - 2014/12/09/ PY - 2014/08/28/received PY - 2014/11/27/accepted PY - 2014/12/10/entrez PY - 2014/12/10/pubmed PY - 2015/7/28/medline SP - 1273 EP - 83 JF - Digestive diseases and sciences JO - Dig Dis Sci VL - 60 IS - 5 N2 - BACKGROUND: Biliary tract cancers encompass gallbladder carcinoma, and intrahepatic, perihilar and distal cholangiocarcinoma. Upregulated serum CYFRA 21-1 has been reported in intrahepatic cholangiocarcinoma. AIMS: The present study aimed to explore the clinical significance of serum CYFRA 21-1 in all biliary tract cancer subtypes. METHODS: Serum CYFRA 21-1, carbohydrate antigen 19-9 and carcinoembryonic antigen were quantitated preoperatively, postoperatively and during follow-up in 134 malignant and 52 benign patients. Receiver operator characteristic curves of biomarkers were analyzed. Level of CYFRA 21-1 was correlated with patients' clinicopathological features and follow-up data. RESULTS: CYFRA 21-1 was significantly upregulated in biliary malignancies, and expressional difference existed between these subtypes. Based on the maximal Youden's index, cutoff values were selected (ng/mL): 2.61 for biliary tract cancers (sensitivity 74.6 % and specificity 84.6 %); 3.27 for intrahepatic cholangiocarcinoma (75.6 and 96.2 %) and gallbladder carcinoma (93.7 and 96.2 %); 2.27 for perihilar cholangiocarcinoma (71.0 and 71.2 %); and 2.61 for distal cholangiocarcinoma (63.3 and 84.6 %). CYFRA 21-1 showed better diagnostic performance than other biomarkers in gallbladder carcinoma and intrahepatic cholangiocarcinoma; its performance was not inferior to that of the combination of these three biomarkers and declined after curative resection and re-elevated when tumor recurred, which was correlated with tumor aggressiveness and TNM stage; it was an independent predictor for 1-year recurrence-free survival and overall survival on multivariate analysis. CONCLUSION: Serum CYFRA 21-1 represents a reliable biomarker for gallbladder carcinoma and intrahepatic cholangiocarcinoma. SN - 1573-2568 UR - https://www.unboundmedicine.com/medline/citation/25487191/Serum_CYFRA_21_1_in_Biliary_Tract_Cancers:_A_Reliable_Biomarker_for_Gallbladder_Carcinoma_and_Intrahepatic_Cholangiocarcinoma_ L2 - https://doi.org/10.1007/s10620-014-3472-0 DB - PRIME DP - Unbound Medicine ER -