Tags

Type your tag names separated by a space and hit enter

Ameliorative potential of angiotensin-converting enzyme inhibitor (ramipril) on chronic constriction injury of sciatic nerve induced neuropathic pain in mice.
J Renin Angiotensin Aldosterone Syst. 2015 Mar; 16(1):103-12.JR

Abstract

INTRODUCTION

The present study was designed to investigate the effect of ramipril (angiotensin-converting enzyme inhibitor) on the chronic constriction injury of sciatic nerve induced neuropathic pain in mice.

METHODS

The neuropathic pain was induced by four loose ligations of the right sciatic nerve in mice. The battery of behavioral tests, i.e. plantar, pin prick, tail flick, tail pinch, rota rod tests, were performed to assess the degree of thermal and mechanical hyperalgesia in ipsilateral paw and tail, and motor in-coordination activity respectively. In addition, the biochemical tests, i.e. total protein, thiobarbituric acid reactive substances and reduced glutathione, were also performed in sciatic nerve tissue samples.

RESULTS

The administration of ramipril (2 and 4 mg/kg, p.o.) significantly attenuated chronic constriction injury-induced rise in peripheral as well as central pain sensitivity (thermal and mechanical) along with impairment of motor in-coordination activity. Further, it also produces ameliorative effects on chronic constriction injury-induced rise in thiobarbituric acid reactive substances and decrease in glutathione levels when compared with a normal control group.

CONCLUSION

It may be concluded that angiotensin-converting enzyme inhibitor may be a potential new target for the management of neuropathic pain.

Authors+Show Affiliations

Department of Pharmacology, Akal College of Pharmacy & Technical Education, Punjab, India.Department of Pharmacology, Akal College of Pharmacy & Technical Education, Punjab, India arunachalammu@gmail.com.Department of Pharmacology, Akal College of Pharmacy & Technical Education, Punjab, India.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25487978

Citation

Kaur, Parneet, et al. "Ameliorative Potential of Angiotensin-converting Enzyme Inhibitor (ramipril) On Chronic Constriction Injury of Sciatic Nerve Induced Neuropathic Pain in Mice." Journal of the Renin-angiotensin-aldosterone System : JRAAS, vol. 16, no. 1, 2015, pp. 103-12.
Kaur P, Muthuraman A, Kaur J. Ameliorative potential of angiotensin-converting enzyme inhibitor (ramipril) on chronic constriction injury of sciatic nerve induced neuropathic pain in mice. J Renin Angiotensin Aldosterone Syst. 2015;16(1):103-12.
Kaur, P., Muthuraman, A., & Kaur, J. (2015). Ameliorative potential of angiotensin-converting enzyme inhibitor (ramipril) on chronic constriction injury of sciatic nerve induced neuropathic pain in mice. Journal of the Renin-angiotensin-aldosterone System : JRAAS, 16(1), 103-12. https://doi.org/10.1177/1470320314556171
Kaur P, Muthuraman A, Kaur J. Ameliorative Potential of Angiotensin-converting Enzyme Inhibitor (ramipril) On Chronic Constriction Injury of Sciatic Nerve Induced Neuropathic Pain in Mice. J Renin Angiotensin Aldosterone Syst. 2015;16(1):103-12. PubMed PMID: 25487978.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ameliorative potential of angiotensin-converting enzyme inhibitor (ramipril) on chronic constriction injury of sciatic nerve induced neuropathic pain in mice. AU - Kaur,Parneet, AU - Muthuraman,Arunachalam, AU - Kaur,Jaspreet, Y1 - 2014/12/08/ PY - 2014/04/17/received PY - 2014/08/09/accepted PY - 2014/12/10/entrez PY - 2014/12/10/pubmed PY - 2016/2/2/medline KW - Angiotensin-converting enzyme KW - plantar test KW - ramipril KW - reduced glutathione KW - renin-angiotensin-aldosterone system SP - 103 EP - 12 JF - Journal of the renin-angiotensin-aldosterone system : JRAAS JO - J Renin Angiotensin Aldosterone Syst VL - 16 IS - 1 N2 - INTRODUCTION: The present study was designed to investigate the effect of ramipril (angiotensin-converting enzyme inhibitor) on the chronic constriction injury of sciatic nerve induced neuropathic pain in mice. METHODS: The neuropathic pain was induced by four loose ligations of the right sciatic nerve in mice. The battery of behavioral tests, i.e. plantar, pin prick, tail flick, tail pinch, rota rod tests, were performed to assess the degree of thermal and mechanical hyperalgesia in ipsilateral paw and tail, and motor in-coordination activity respectively. In addition, the biochemical tests, i.e. total protein, thiobarbituric acid reactive substances and reduced glutathione, were also performed in sciatic nerve tissue samples. RESULTS: The administration of ramipril (2 and 4 mg/kg, p.o.) significantly attenuated chronic constriction injury-induced rise in peripheral as well as central pain sensitivity (thermal and mechanical) along with impairment of motor in-coordination activity. Further, it also produces ameliorative effects on chronic constriction injury-induced rise in thiobarbituric acid reactive substances and decrease in glutathione levels when compared with a normal control group. CONCLUSION: It may be concluded that angiotensin-converting enzyme inhibitor may be a potential new target for the management of neuropathic pain. SN - 1752-8976 UR - https://www.unboundmedicine.com/medline/citation/25487978/Ameliorative_potential_of_angiotensin_converting_enzyme_inhibitor__ramipril__on_chronic_constriction_injury_of_sciatic_nerve_induced_neuropathic_pain_in_mice_ L2 - https://journals.sagepub.com/doi/10.1177/1470320314556171?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -