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Orally administered allyl sulfides from garlic ameliorate murine colitis.
Mol Nutr Food Res 2015; 59(3):434-42MN

Abstract

SCOPE

Inflammatory bowel disease (IBD) is an incurable disease which affects millions of people. Garlic (Allium sativum) preparations have been traditionally employed for the treatment of diseases affecting the digestive tract. Here, we have investigated the effect of diallyl sulfide (DAS) and diallyl disulfide (DADS), two garlic-derived sulfur compounds, on intestinal inflammation in vivo as well as in intestinal isolated cells.

METHODS AND RESULTS

Colitis was induced in mice by intracolonic administration of dinitrobenzenesulfonic acid. Intestinal damage was assessed by evaluating colon weight/colon length ratio and by histology. Murine intestinal epithelial cells stimulated with IFN-γ were used to evaluate the possible in vitro DAS and DADS anti-inflammatory effects. DAS and DADS, given for two consecutive days after DNBS administration, reduced inflammation and damage. In IFN-γ-stimulated intestinal epithelial cells, DADS reduced IP-10 and IL-6 levels, while DAS inhibited nitric oxide production and STAT-1 expression.

CONCLUSION

DAS and DADS exert therapeutic effects in the DNBS model of colitis. The actions of these compounds on the production of IP-10, IL-6, hydrogen sulfide or nitric oxide and on the expression of STAT-1 observed in intestinal cells stimulated with IFN-γ, might explain the protective action of DAS and DADS in experimental IBD.

Authors+Show Affiliations

Department of Pharmacy, University of Naples Federico II, Naples, Italy; Chair of Nutrition and Immunology, ZIEL, Research Center for Nutrition and Food Sciences, Technical University Munich, Freising, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25488545

Citation

Fasolino, Ines, et al. "Orally Administered Allyl Sulfides From Garlic Ameliorate Murine Colitis." Molecular Nutrition & Food Research, vol. 59, no. 3, 2015, pp. 434-42.
Fasolino I, Izzo AA, Clavel T, et al. Orally administered allyl sulfides from garlic ameliorate murine colitis. Mol Nutr Food Res. 2015;59(3):434-42.
Fasolino, I., Izzo, A. A., Clavel, T., Romano, B., Haller, D., & Borrelli, F. (2015). Orally administered allyl sulfides from garlic ameliorate murine colitis. Molecular Nutrition & Food Research, 59(3), pp. 434-42. doi:10.1002/mnfr.201400347.
Fasolino I, et al. Orally Administered Allyl Sulfides From Garlic Ameliorate Murine Colitis. Mol Nutr Food Res. 2015;59(3):434-42. PubMed PMID: 25488545.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Orally administered allyl sulfides from garlic ameliorate murine colitis. AU - Fasolino,Ines, AU - Izzo,Angelo A, AU - Clavel,Thomas, AU - Romano,Barbara, AU - Haller,Dirk, AU - Borrelli,Francesca, Y1 - 2015/01/21/ PY - 2014/05/22/received PY - 2014/11/21/revised PY - 2014/12/01/accepted PY - 2014/12/10/entrez PY - 2014/12/10/pubmed PY - 2016/4/26/medline KW - Colitis KW - Diallyl disulfide KW - Diallyl sulfide KW - Epithelial cells KW - Food supplement KW - Garlic KW - Hydrogen sulfide KW - IFN-γ KW - Inflammatory bowel disease KW - Nitric oxide SP - 434 EP - 42 JF - Molecular nutrition & food research JO - Mol Nutr Food Res VL - 59 IS - 3 N2 - SCOPE: Inflammatory bowel disease (IBD) is an incurable disease which affects millions of people. Garlic (Allium sativum) preparations have been traditionally employed for the treatment of diseases affecting the digestive tract. Here, we have investigated the effect of diallyl sulfide (DAS) and diallyl disulfide (DADS), two garlic-derived sulfur compounds, on intestinal inflammation in vivo as well as in intestinal isolated cells. METHODS AND RESULTS: Colitis was induced in mice by intracolonic administration of dinitrobenzenesulfonic acid. Intestinal damage was assessed by evaluating colon weight/colon length ratio and by histology. Murine intestinal epithelial cells stimulated with IFN-γ were used to evaluate the possible in vitro DAS and DADS anti-inflammatory effects. DAS and DADS, given for two consecutive days after DNBS administration, reduced inflammation and damage. In IFN-γ-stimulated intestinal epithelial cells, DADS reduced IP-10 and IL-6 levels, while DAS inhibited nitric oxide production and STAT-1 expression. CONCLUSION: DAS and DADS exert therapeutic effects in the DNBS model of colitis. The actions of these compounds on the production of IP-10, IL-6, hydrogen sulfide or nitric oxide and on the expression of STAT-1 observed in intestinal cells stimulated with IFN-γ, might explain the protective action of DAS and DADS in experimental IBD. SN - 1613-4133 UR - https://www.unboundmedicine.com/medline/citation/25488545/Orally_administered_allyl_sulfides_from_garlic_ameliorate_murine_colitis_ L2 - https://doi.org/10.1002/mnfr.201400347 DB - PRIME DP - Unbound Medicine ER -