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Obesity and PCOS: the effect of metabolic derangements on endometrial receptivity at the time of implantation.
Reprod Sci. 2015 Jan; 22(1):6-14.RS

Abstract

Successful embryonic implantation is the result of a receptive endometrium, a functional embryo at the blastocyst stage and a synchronized dialog between maternal and embryonic tissues. Successful implantation requires the endometrium to undergo steroid-dependent change during each menstrual cycle, exhibiting a short period of embryonic receptivity known as the window of implantation. The term "endometrial receptivity" was introduced to define the state of the endometrium during the window of implantation. It refers to the ability of the endometrium to undergo changes that will allow the blastocyst to attach, penetrate, and induce localized changes in the endometrial stroma. These changes are metabolically demanding, and glucose metabolism has been proven to be important for the preparation of the endometrium for embryo implantation. Obesity and polycystic ovary syndrome (PCOS) represent 2 common metabolic disorders that are associated with subfertility. The aim of this review is to summarize the effect of obesity and PCOS on endometrial receptivity at the time of implantation. Focus will be on metabolic alterations that regulate decidualization, including glucose metabolism, hyperinsulinemia, and hyperandrogenism.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, MO, USA.Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, MO, USA.Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, MO, USA moleyk@wustl.edu.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

25488942

Citation

Schulte, Maureen M B., et al. "Obesity and PCOS: the Effect of Metabolic Derangements On Endometrial Receptivity at the Time of Implantation." Reproductive Sciences (Thousand Oaks, Calif.), vol. 22, no. 1, 2015, pp. 6-14.
Schulte MM, Tsai JH, Moley KH. Obesity and PCOS: the effect of metabolic derangements on endometrial receptivity at the time of implantation. Reprod Sci. 2015;22(1):6-14.
Schulte, M. M., Tsai, J. H., & Moley, K. H. (2015). Obesity and PCOS: the effect of metabolic derangements on endometrial receptivity at the time of implantation. Reproductive Sciences (Thousand Oaks, Calif.), 22(1), 6-14. https://doi.org/10.1177/1933719114561552
Schulte MM, Tsai JH, Moley KH. Obesity and PCOS: the Effect of Metabolic Derangements On Endometrial Receptivity at the Time of Implantation. Reprod Sci. 2015;22(1):6-14. PubMed PMID: 25488942.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Obesity and PCOS: the effect of metabolic derangements on endometrial receptivity at the time of implantation. AU - Schulte,Maureen M B, AU - Tsai,Jui-he, AU - Moley,Kelle H, Y1 - 2014/12/07/ PY - 2014/12/10/entrez PY - 2014/12/10/pubmed PY - 2016/3/17/medline KW - PCOS KW - endometrial receptivity KW - implantation KW - metabolism KW - obesity SP - 6 EP - 14 JF - Reproductive sciences (Thousand Oaks, Calif.) JO - Reprod Sci VL - 22 IS - 1 N2 - Successful embryonic implantation is the result of a receptive endometrium, a functional embryo at the blastocyst stage and a synchronized dialog between maternal and embryonic tissues. Successful implantation requires the endometrium to undergo steroid-dependent change during each menstrual cycle, exhibiting a short period of embryonic receptivity known as the window of implantation. The term "endometrial receptivity" was introduced to define the state of the endometrium during the window of implantation. It refers to the ability of the endometrium to undergo changes that will allow the blastocyst to attach, penetrate, and induce localized changes in the endometrial stroma. These changes are metabolically demanding, and glucose metabolism has been proven to be important for the preparation of the endometrium for embryo implantation. Obesity and polycystic ovary syndrome (PCOS) represent 2 common metabolic disorders that are associated with subfertility. The aim of this review is to summarize the effect of obesity and PCOS on endometrial receptivity at the time of implantation. Focus will be on metabolic alterations that regulate decidualization, including glucose metabolism, hyperinsulinemia, and hyperandrogenism. SN - 1933-7205 UR - https://www.unboundmedicine.com/medline/citation/25488942/Obesity_and_PCOS:_the_effect_of_metabolic_derangements_on_endometrial_receptivity_at_the_time_of_implantation_ L2 - http://journals.sagepub.com/doi/full/10.1177/1933719114561552?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -