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In situ synthesis of magnetic CaraPVA IPN nanocomposite hydrogels and controlled drug release.
Mater Sci Eng C Mater Biol Appl. 2014 Dec; 45:250-60.MS

Abstract

In this work, the magnetic nanocomposite hydrogels that focused on targeted drug delivery were synthesized by incorporation of polyvinyl alcohol (PVA), kappa-carrageenan (Cara), and magnetite Fe3O4 nanoparticles. The magnetic nanoparticles were obtained in situ in the presence of a mixture of polyvinyl alcohol/kappa-carrageenan (CaraPVA). The produced magnetite-polymers were cross-linked with freezing-thawing technique and subsequent with K(+) solution. The synthesized hydrogels were thoroughly characterized by transmittance electron microscopy (TEM), scanning electron microscopy (SEM), X-ray diffraction (XRD), thermal gravimetric analysis (TGA), Fourier transform infrared spectroscopy (FT-IR), and vibrating sample magnetometer (VSM) techniques. The dynamic swelling kinetic models of hydrogels were analyzed according to the first- and second-order kinetic models and were found that the experimental kinetics data followed the second-order model well. Drug loading and release efficiency were evaluated by diclofenac sodium (DS) as the model drug. The in vitro drug release studies from hydrogels exhibited significant behaviors on the subject of physiological simulated pHs and external magnetic fields. Investigation on the antibacterial activity revealed the ability of drug-loaded hydrogels to inactivate the Gram-positive Staphylococcus aureus (S. aureus) bacteria. The mucoadhesive properties of the hydrogels were studied and the hydrogels containing kappa-carrageenan showed good mucoadhesiveness in both simulated gastric and intestinal conditions.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Mahdavinia GR
Department of Chemistry, Faculty of Science, University of Maragheh, 55181-83111, Maragheh, Iran. Electronic address: grmnia@maragheh.ac.ir.
Etemadi H
Department of Chemistry, Faculty of Science, University of Maragheh, 55181-83111, Maragheh, Iran.

MeSH

AdsorptionAnti-Bacterial AgentsCarrageenanDiclofenacDrug CarriersDrug LiberationFerrosoferric OxideHydrogelsHydrogen-Ion ConcentrationMagnetic FieldsMagnetite NanoparticlesMicroscopy, Electron, ScanningMucinsPolyvinyl AlcoholSpectroscopy, Fourier Transform InfraredStaphylococcus aureusThermogravimetryX-Ray Diffraction

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25491827

Citation

Mahdavinia, Gholam Reza, and Hossein Etemadi. "In Situ Synthesis of Magnetic CaraPVA IPN Nanocomposite Hydrogels and Controlled Drug Release." Materials Science & Engineering. C, Materials for Biological Applications, vol. 45, 2014, pp. 250-60.
Mahdavinia GR, Etemadi H. In situ synthesis of magnetic CaraPVA IPN nanocomposite hydrogels and controlled drug release. Mater Sci Eng C Mater Biol Appl. 2014;45:250-60.
Mahdavinia, G. R., & Etemadi, H. (2014). In situ synthesis of magnetic CaraPVA IPN nanocomposite hydrogels and controlled drug release. Materials Science & Engineering. C, Materials for Biological Applications, 45, 250-60. https://doi.org/10.1016/j.msec.2014.09.023
Mahdavinia GR, Etemadi H. In Situ Synthesis of Magnetic CaraPVA IPN Nanocomposite Hydrogels and Controlled Drug Release. Mater Sci Eng C Mater Biol Appl. 2014;45:250-60. PubMed PMID: 25491827.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In situ synthesis of magnetic CaraPVA IPN nanocomposite hydrogels and controlled drug release. AU - Mahdavinia,Gholam Reza, AU - Etemadi,Hossein, Y1 - 2014/09/16/ PY - 2013/12/25/received PY - 2014/08/04/revised PY - 2014/09/12/accepted PY - 2014/12/11/entrez PY - 2014/12/11/pubmed PY - 2015/8/22/medline KW - Drug release KW - Hydrogel KW - Magnetic KW - Polyvinyl alcohol KW - kappa-Carrageenan SP - 250 EP - 60 JF - Materials science & engineering. C, Materials for biological applications JO - Mater Sci Eng C Mater Biol Appl VL - 45 N2 - In this work, the magnetic nanocomposite hydrogels that focused on targeted drug delivery were synthesized by incorporation of polyvinyl alcohol (PVA), kappa-carrageenan (Cara), and magnetite Fe3O4 nanoparticles. The magnetic nanoparticles were obtained in situ in the presence of a mixture of polyvinyl alcohol/kappa-carrageenan (CaraPVA). The produced magnetite-polymers were cross-linked with freezing-thawing technique and subsequent with K(+) solution. The synthesized hydrogels were thoroughly characterized by transmittance electron microscopy (TEM), scanning electron microscopy (SEM), X-ray diffraction (XRD), thermal gravimetric analysis (TGA), Fourier transform infrared spectroscopy (FT-IR), and vibrating sample magnetometer (VSM) techniques. The dynamic swelling kinetic models of hydrogels were analyzed according to the first- and second-order kinetic models and were found that the experimental kinetics data followed the second-order model well. Drug loading and release efficiency were evaluated by diclofenac sodium (DS) as the model drug. The in vitro drug release studies from hydrogels exhibited significant behaviors on the subject of physiological simulated pHs and external magnetic fields. Investigation on the antibacterial activity revealed the ability of drug-loaded hydrogels to inactivate the Gram-positive Staphylococcus aureus (S. aureus) bacteria. The mucoadhesive properties of the hydrogels were studied and the hydrogels containing kappa-carrageenan showed good mucoadhesiveness in both simulated gastric and intestinal conditions. SN - 1873-0191 UR - https://www.unboundmedicine.com/medline/citation/25491827/In_situ_synthesis_of_magnetic_CaraPVA_IPN_nanocomposite_hydrogels_and_controlled_drug_release_ DB - PRIME DP - Unbound Medicine ER -