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Exposure to free and conjugated forms of bisphenol A and triclosan among pregnant women in the MIREC cohort.
Environ Health Perspect. 2015 Apr; 123(4):277-84.EH

Abstract

BACKGROUND

Bisphenol A (BPA) and triclosan (TCS) are two nonpersistent chemicals that have been frequently measured in spot urine samples from the general population but less so in pregnant women; however, data are limited on the free (bioactive) and conjugated forms of these phenols.

OBJECTIVES

The Maternal-Infant Research on Environmental Chemicals (MIREC) Study addressed these data gaps by utilizing stored maternal urine samples from a large multicenter cohort study of Canadian pregnant women.

METHODS

Concentrations of free and conjugated forms of BPA and TCS were measured in about 1,890 first-trimester urine samples by ultra performance liquid chromatography-tandem mass spectrometry using isotope dilution.

RESULTS

The glucuronides of BPA and TCS were the predominant forms of these chemicals measured (detected in 95% and 99% of samples, respectively), whereas the free forms were detected in 43% and 80% of samples, respectively. The geometric mean urinary concentrations for glucuronides of BPA and TCS were 0.80 μg/L (95% CI: 0.75, 0.85) and 12.30 μg/L (95% CI: 11.08, 13.65), respectively. Significant predictors of BPA included maternal age < 25 vs. ≥ 35 years, current smoking, low vs. high household income, and low vs. high education. For TCS, urinary concentrations were significantly higher in women ≥ 25 years of age, never vs. current smokers, and women with high household income and high education.

CONCLUSIONS

The results from this study represent the largest national-level data on urinary concentrations of free and conjugated forms of BPA and TCS in pregnant women and suggest that maternal characteristics predicting elevated urinary concentrations of these phenols largely act in opposite directions.

Authors+Show Affiliations

Population Studies Division, Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, Ontario, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25494523

Citation

Arbuckle, Tye E., et al. "Exposure to Free and Conjugated Forms of Bisphenol a and Triclosan Among Pregnant Women in the MIREC Cohort." Environmental Health Perspectives, vol. 123, no. 4, 2015, pp. 277-84.
Arbuckle TE, Marro L, Davis K, et al. Exposure to free and conjugated forms of bisphenol A and triclosan among pregnant women in the MIREC cohort. Environ Health Perspect. 2015;123(4):277-84.
Arbuckle, T. E., Marro, L., Davis, K., Fisher, M., Ayotte, P., Bélanger, P., Dumas, P., LeBlanc, A., Bérubé, R., Gaudreau, É., Provencher, G., Faustman, E. M., Vigoren, E., Ettinger, A. S., Dellarco, M., MacPherson, S., & Fraser, W. D. (2015). Exposure to free and conjugated forms of bisphenol A and triclosan among pregnant women in the MIREC cohort. Environmental Health Perspectives, 123(4), 277-84. https://doi.org/10.1289/ehp.1408187
Arbuckle TE, et al. Exposure to Free and Conjugated Forms of Bisphenol a and Triclosan Among Pregnant Women in the MIREC Cohort. Environ Health Perspect. 2015;123(4):277-84. PubMed PMID: 25494523.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Exposure to free and conjugated forms of bisphenol A and triclosan among pregnant women in the MIREC cohort. AU - Arbuckle,Tye E, AU - Marro,Leonora, AU - Davis,Karelyn, AU - Fisher,Mandy, AU - Ayotte,Pierre, AU - Bélanger,Patrick, AU - Dumas,Pierre, AU - LeBlanc,Alain, AU - Bérubé,René, AU - Gaudreau,Éric, AU - Provencher,Gilles, AU - Faustman,Elaine M, AU - Vigoren,Eric, AU - Ettinger,Adrienne S, AU - Dellarco,Michael, AU - MacPherson,Susan, AU - Fraser,William D, Y1 - 2014/11/21/ PY - 2014/01/28/received PY - 2014/11/19/accepted PY - 2014/12/11/entrez PY - 2014/12/11/pubmed PY - 2016/1/28/medline SP - 277 EP - 84 JF - Environmental health perspectives JO - Environ. Health Perspect. VL - 123 IS - 4 N2 - BACKGROUND: Bisphenol A (BPA) and triclosan (TCS) are two nonpersistent chemicals that have been frequently measured in spot urine samples from the general population but less so in pregnant women; however, data are limited on the free (bioactive) and conjugated forms of these phenols. OBJECTIVES: The Maternal-Infant Research on Environmental Chemicals (MIREC) Study addressed these data gaps by utilizing stored maternal urine samples from a large multicenter cohort study of Canadian pregnant women. METHODS: Concentrations of free and conjugated forms of BPA and TCS were measured in about 1,890 first-trimester urine samples by ultra performance liquid chromatography-tandem mass spectrometry using isotope dilution. RESULTS: The glucuronides of BPA and TCS were the predominant forms of these chemicals measured (detected in 95% and 99% of samples, respectively), whereas the free forms were detected in 43% and 80% of samples, respectively. The geometric mean urinary concentrations for glucuronides of BPA and TCS were 0.80 μg/L (95% CI: 0.75, 0.85) and 12.30 μg/L (95% CI: 11.08, 13.65), respectively. Significant predictors of BPA included maternal age < 25 vs. ≥ 35 years, current smoking, low vs. high household income, and low vs. high education. For TCS, urinary concentrations were significantly higher in women ≥ 25 years of age, never vs. current smokers, and women with high household income and high education. CONCLUSIONS: The results from this study represent the largest national-level data on urinary concentrations of free and conjugated forms of BPA and TCS in pregnant women and suggest that maternal characteristics predicting elevated urinary concentrations of these phenols largely act in opposite directions. SN - 1552-9924 UR - https://www.unboundmedicine.com/medline/citation/25494523/Exposure_to_free_and_conjugated_forms_of_bisphenol_A_and_triclosan_among_pregnant_women_in_the_MIREC_cohort_ L2 - https://ehp.niehs.nih.gov/doi/full/10.1289/ehp.1408187?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -