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Severe vitamin D deficiency is associated with frequent exacerbations and hospitalization in COPD patients.
Respir Res 2014; 15:131RR

Abstract

BACKGROUND

Acute exacerbations of COPD (AECOPD) are common and strongly influence disease severity and relative healthcare costs. Vitamin D deficiency is frequent among COPD patients and its contributory role in disease exacerbations is widely debated. Our aim was to assess the relationship of serum vitamin D levels with COPD severity and AECOPD.

METHODS

Serum vitamin D (25-hydroxyvitamin D) levels were measured in 97 COPD patients and related to lung function, comorbidities, FEV1 decline, AECOPD and hospital admission during the previous year.

RESULTS

Most patients (96%) had vitamin D deficiency, which was severe in 35 (36%). No significant relationship was found between vitamin D and FEV1 or annual FEV1 decline. No difference between patients with and without severe vitamin D deficiency was found in age, gender, BMI, smoking history, lung function, and comorbidities, apart from osteoporosis (60.9% in severe deficiency vs 22.7%, p = 0.001). In multiple logistic regression models, severe deficiency was independently associated with AECOPD [adjusted odds ratios (aOR) of 30.5 (95% CI 5.55, 168), p < 0.001] and hospitalization [aOR 3.83 (95% CI 1.29, 11.4), p = 0.02]. The odds ratio of being a frequent exacerbator if having severe vitamin D deficiency was 18.1 (95% CI 4.98, 65.8) (p < 0.001), while that of hospitalization was 4.57 (95% CI 1.83, 11.4) (p = 0.001).

CONCLUSIONS

In COPD patients severe vitamin D deficiency was related to more frequent disease exacerbations and hospitalization during the year previous to the measurement of vitamin D. This association was independent of patients' characteristics and comorbidities.

Authors+Show Affiliations

Department of Medical Sciences, Clinical Physiology, Uppsala University, Uppsala, Sweden. andrei.malinovschi@medsci.uu.se.Department of Medical Sciences, University of Turin, Via Lamarmora 41, 10128, Turin, Italy. raerte@yahoo.it.Department of Medical Sciences, University of Turin, Via Lamarmora 41, 10128, Turin, Italy. michela.bellocchia@libero.it.Department of Medical Sciences, University of Turin, Via Lamarmora 41, 10128, Turin, Italy. antociu88@gmail.com.Cardiovascular and Thoracic Department, Città della Salute, Turin, Italy. psolidoro@cittadellasalute.to.it.Cardiovascular and Thoracic Department, Città della Salute, Turin, Italy. amattei@cittadellasalute.to.it.Cardiovascular and Thoracic Department, Città della Salute, Turin, Italy. lmercante@cittadellasalute.to.it.Department of Medical Sciences, University of Turin, Via Lamarmora 41, 10128, Turin, Italy. heffler.enrico@gmail.com.Department of Medical Sciences, University of Turin, Via Lamarmora 41, 10128, Turin, Italy. giovanni.rolla@unito.it.Department of Medical Sciences, University of Turin, Via Lamarmora 41, 10128, Turin, Italy. caterina.bucca@unito.it.

Pub Type(s)

Journal Article
Observational Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25496239

Citation

Malinovschi, Andrei, et al. "Severe Vitamin D Deficiency Is Associated With Frequent Exacerbations and Hospitalization in COPD Patients." Respiratory Research, vol. 15, 2014, p. 131.
Malinovschi A, Masoero M, Bellocchia M, et al. Severe vitamin D deficiency is associated with frequent exacerbations and hospitalization in COPD patients. Respir Res. 2014;15:131.
Malinovschi, A., Masoero, M., Bellocchia, M., Ciuffreda, A., Solidoro, P., Mattei, A., ... Bucca, C. (2014). Severe vitamin D deficiency is associated with frequent exacerbations and hospitalization in COPD patients. Respiratory Research, 15, p. 131. doi:10.1186/s12931-014-0131-0.
Malinovschi A, et al. Severe Vitamin D Deficiency Is Associated With Frequent Exacerbations and Hospitalization in COPD Patients. Respir Res. 2014 Dec 13;15:131. PubMed PMID: 25496239.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Severe vitamin D deficiency is associated with frequent exacerbations and hospitalization in COPD patients. AU - Malinovschi,Andrei, AU - Masoero,Monica, AU - Bellocchia,Michela, AU - Ciuffreda,Antonio, AU - Solidoro,Paolo, AU - Mattei,Alessio, AU - Mercante,Lorena, AU - Heffler,Enrico, AU - Rolla,Giovanni, AU - Bucca,Caterina, Y1 - 2014/12/13/ PY - 2014/07/03/received PY - 2014/10/14/accepted PY - 2014/12/16/entrez PY - 2014/12/17/pubmed PY - 2015/12/19/medline SP - 131 EP - 131 JF - Respiratory research JO - Respir. Res. VL - 15 N2 - BACKGROUND: Acute exacerbations of COPD (AECOPD) are common and strongly influence disease severity and relative healthcare costs. Vitamin D deficiency is frequent among COPD patients and its contributory role in disease exacerbations is widely debated. Our aim was to assess the relationship of serum vitamin D levels with COPD severity and AECOPD. METHODS: Serum vitamin D (25-hydroxyvitamin D) levels were measured in 97 COPD patients and related to lung function, comorbidities, FEV1 decline, AECOPD and hospital admission during the previous year. RESULTS: Most patients (96%) had vitamin D deficiency, which was severe in 35 (36%). No significant relationship was found between vitamin D and FEV1 or annual FEV1 decline. No difference between patients with and without severe vitamin D deficiency was found in age, gender, BMI, smoking history, lung function, and comorbidities, apart from osteoporosis (60.9% in severe deficiency vs 22.7%, p = 0.001). In multiple logistic regression models, severe deficiency was independently associated with AECOPD [adjusted odds ratios (aOR) of 30.5 (95% CI 5.55, 168), p < 0.001] and hospitalization [aOR 3.83 (95% CI 1.29, 11.4), p = 0.02]. The odds ratio of being a frequent exacerbator if having severe vitamin D deficiency was 18.1 (95% CI 4.98, 65.8) (p < 0.001), while that of hospitalization was 4.57 (95% CI 1.83, 11.4) (p = 0.001). CONCLUSIONS: In COPD patients severe vitamin D deficiency was related to more frequent disease exacerbations and hospitalization during the year previous to the measurement of vitamin D. This association was independent of patients' characteristics and comorbidities. SN - 1465-993X UR - https://www.unboundmedicine.com/medline/citation/25496239/Severe_vitamin_D_deficiency_is_associated_with_frequent_exacerbations_and_hospitalization_in_COPD_patients_ L2 - https://respiratory-research.biomedcentral.com/articles/10.1186/s12931-014-0131-0 DB - PRIME DP - Unbound Medicine ER -