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Expression of HLA-A, -B, -C, -DR, -DP, -DQ, and of HLA-D-associated invariant chain (Ii) in non-neoplastic mammary epithelium, fibroadenoma, adenoma, and carcinoma of the breast.
Am J Pathol. 1989 Jul; 135(1):73-83.AJ

Abstract

Non-neoplastic mammary gland, 20 benign tumors and 206 carcinomas of the breast were immunohistochemically examined for expression of HLA-A, -B, -C, HLA-DR, -DP, and -DQ molecules and the HLA-D associated invariant chain (Ii). In contrast to cells from benign lesions, tumor cells of 51.2% of carcinomas had an abnormally low content of HLA-A, -B, and -C determinants ranging from reduction of antigenic density per cell (28.8%) over an incomplete (15.6%) to complete loss of antigens (6.8%). Associated with lymphohistiocytic stromal infiltrates, HLA-D/Ii determinants were found to be induced in benign duct and acinar epithelium after the order Ii greater than or equal to HLA-DR greater than or equal to HLA-DP greater than or equal to HLA-DQ. These antigens were also expressed, mostly noncoordinately, in 55.5% of carcinomas, and in 98 cases according to the above order. In 28.6%, Ii expression clearly exceeded HLA-D antigen expression; conversely, 6.2% contained HLA-DR+/Ii- tumor cell subsets. In breast carcinoma, the association of reduced HLA-A, -B, and -C expression and a noninduction of HLA-DR was highly significant (P less than 0.0009), suggesting an abnormal signal acting down-regulating on the expression of both classes of antigens. Because the modality of HLA-A, -B, and -C and HLA-D/Ii expression correlated with neither tumor type nor grade, it might be an independent parameter.

Authors+Show Affiliations

Institute of Pathology, Heidelberg University, West Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2549795

Citation

Möller, P, et al. "Expression of HLA-A, -B, -C, -DR, -DP, -DQ, and of HLA-D-associated Invariant Chain (Ii) in Non-neoplastic Mammary Epithelium, Fibroadenoma, Adenoma, and Carcinoma of the Breast." The American Journal of Pathology, vol. 135, no. 1, 1989, pp. 73-83.
Möller P, Mattfeldt T, Gross C, et al. Expression of HLA-A, -B, -C, -DR, -DP, -DQ, and of HLA-D-associated invariant chain (Ii) in non-neoplastic mammary epithelium, fibroadenoma, adenoma, and carcinoma of the breast. Am J Pathol. 1989;135(1):73-83.
Möller, P., Mattfeldt, T., Gross, C., Schlosshauer, P., Koch, A., Koretz, K., Moldenhauer, G., Kaufmann, M., & Otto, H. F. (1989). Expression of HLA-A, -B, -C, -DR, -DP, -DQ, and of HLA-D-associated invariant chain (Ii) in non-neoplastic mammary epithelium, fibroadenoma, adenoma, and carcinoma of the breast. The American Journal of Pathology, 135(1), 73-83.
Möller P, et al. Expression of HLA-A, -B, -C, -DR, -DP, -DQ, and of HLA-D-associated Invariant Chain (Ii) in Non-neoplastic Mammary Epithelium, Fibroadenoma, Adenoma, and Carcinoma of the Breast. Am J Pathol. 1989;135(1):73-83. PubMed PMID: 2549795.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Expression of HLA-A, -B, -C, -DR, -DP, -DQ, and of HLA-D-associated invariant chain (Ii) in non-neoplastic mammary epithelium, fibroadenoma, adenoma, and carcinoma of the breast. AU - Möller,P, AU - Mattfeldt,T, AU - Gross,C, AU - Schlosshauer,P, AU - Koch,A, AU - Koretz,K, AU - Moldenhauer,G, AU - Kaufmann,M, AU - Otto,H F, PY - 1989/7/1/pubmed PY - 1989/7/1/medline PY - 1989/7/1/entrez SP - 73 EP - 83 JF - The American journal of pathology JO - Am J Pathol VL - 135 IS - 1 N2 - Non-neoplastic mammary gland, 20 benign tumors and 206 carcinomas of the breast were immunohistochemically examined for expression of HLA-A, -B, -C, HLA-DR, -DP, and -DQ molecules and the HLA-D associated invariant chain (Ii). In contrast to cells from benign lesions, tumor cells of 51.2% of carcinomas had an abnormally low content of HLA-A, -B, and -C determinants ranging from reduction of antigenic density per cell (28.8%) over an incomplete (15.6%) to complete loss of antigens (6.8%). Associated with lymphohistiocytic stromal infiltrates, HLA-D/Ii determinants were found to be induced in benign duct and acinar epithelium after the order Ii greater than or equal to HLA-DR greater than or equal to HLA-DP greater than or equal to HLA-DQ. These antigens were also expressed, mostly noncoordinately, in 55.5% of carcinomas, and in 98 cases according to the above order. In 28.6%, Ii expression clearly exceeded HLA-D antigen expression; conversely, 6.2% contained HLA-DR+/Ii- tumor cell subsets. In breast carcinoma, the association of reduced HLA-A, -B, and -C expression and a noninduction of HLA-DR was highly significant (P less than 0.0009), suggesting an abnormal signal acting down-regulating on the expression of both classes of antigens. Because the modality of HLA-A, -B, and -C and HLA-D/Ii expression correlated with neither tumor type nor grade, it might be an independent parameter. SN - 0002-9440 UR - https://www.unboundmedicine.com/medline/citation/2549795/Expression_of_HLA_A__B__C__DR__DP__DQ_and_of_HLA_D_associated_invariant_chain__Ii__in_non_neoplastic_mammary_epithelium_fibroadenoma_adenoma_and_carcinoma_of_the_breast_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/2549795/ DB - PRIME DP - Unbound Medicine ER -