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Traffic pollution is associated with early childhood aeroallergen sensitization.

Abstract

BACKGROUND

No large, prospective, epidemiologic study has investigated the association between diesel exhaust particle (DEP) exposure and early aeroallergen sensitization and allergic rhinitis (AR) at 4 years of age.

OBJECTIVE

To determine how exposure to traffic exhaust during infancy is associated with aeroallergen sensitization and AR at 4 years of age and the predictive utility of the wheal area at 1 to 3 years of age on AR at 4 years of age.

METHODS

Infants born to aeroallergen sensitized parents were evaluated annually with skin prick tests to 15 aeroallergens with measurement of wheal areas. At 4 years of age, AR was defined as at least one positive aeroallergen skin prick test result and the presence of sneezing and a runny nose without a cold or flu. Infant (DEP) exposure was estimated using data from 27 air sampling monitors and a land use regression model.

RESULTS

Complete data were available for 634 children at 4 years of age. Prevalence of AR increased annually from 6.9% to 21.9%. A positive trend was observed for high DEP exposure and aeroallergen sensitization at 2 and 3 years of age (odds ratio, 1.40; 95% confidence interval, 0.97-2.0) and (odds ratio, 1.35; 95% confidence interval, 0.98-1.85) but not with AR. At 2 years of age, every 1-mm(2) increase in the wheal area of timothy and Alternaria significantly increased the odds of AR at 4 years of age. At 3 years of age, every 1-mm(2) increase in the wheal area of fescue, dog, and Penicillium significantly increased the odds of AR at 4 years of age.

CONCLUSION

DEP exposure enhances the risk of early aeroallergen sensitization. Aeroallergen wheal area at 2 and 3 years of age is associated with AR at 4 years of age.

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  • Authors+Show Affiliations

    ,

    Department of Internal Medicine, Division of Immunology/Allergy, University of Cincinnati, Cincinnati, Ohio; Department of Environmental Health, University of Cincinnati, Cincinnati, Ohio; Division of Immunology, Microbiology, and Allergy, Rush University Medical Center, Chicago, Illinois. Electronic address: Christopher_d_Codispoti@rush.edu.

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    Department of Environmental Health, University of Cincinnati, Cincinnati, Ohio.

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    Department of Environmental Health, University of Cincinnati, Cincinnati, Ohio.

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    Department of Environmental Health, University of Cincinnati, Cincinnati, Ohio.

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    Department of Environmental Health, University of Cincinnati, Cincinnati, Ohio; Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

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    Division of Asthma Research, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

    ,

    Department of Internal Medicine, Division of Immunology/Allergy, University of Cincinnati, Cincinnati, Ohio.

    ,

    Department of Environmental Health, University of Cincinnati, Cincinnati, Ohio.

    ,

    Department of Internal Medicine, Division of Immunology/Allergy, University of Cincinnati, Cincinnati, Ohio.

    ,

    Department of Environmental Health, University of Cincinnati, Cincinnati, Ohio.

    ,

    Division of Asthma Research, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

    Department of Internal Medicine, Division of Immunology/Allergy, University of Cincinnati, Cincinnati, Ohio.

    Source

    MeSH

    Air Pollutants
    Air Pollution
    Allergens
    Alternaria
    Child, Preschool
    Female
    Humans
    Infant
    Inhalation Exposure
    Male
    Parents
    Penicillium
    Prospective Studies
    Rhinitis, Allergic
    Skin Tests
    Surveys and Questionnaires
    Vehicle Emissions

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural

    Language

    eng

    PubMed ID

    25499550

    Citation

    Codispoti, Christopher D., et al. "Traffic Pollution Is Associated With Early Childhood Aeroallergen Sensitization." Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology, vol. 114, no. 2, 2015, pp. 126-33.
    Codispoti CD, LeMasters GK, Levin L, et al. Traffic pollution is associated with early childhood aeroallergen sensitization. Ann Allergy Asthma Immunol. 2015;114(2):126-33.
    Codispoti, C. D., LeMasters, G. K., Levin, L., Reponen, T., Ryan, P. H., Biagini Myers, J. M., ... Bernstein, D. I. (2015). Traffic pollution is associated with early childhood aeroallergen sensitization. Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology, 114(2), pp. 126-33. doi:10.1016/j.anai.2014.10.020.
    Codispoti CD, et al. Traffic Pollution Is Associated With Early Childhood Aeroallergen Sensitization. Ann Allergy Asthma Immunol. 2015;114(2):126-33. PubMed PMID: 25499550.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Traffic pollution is associated with early childhood aeroallergen sensitization. AU - Codispoti,Christopher D, AU - LeMasters,Grace K, AU - Levin,Linda, AU - Reponen,Tiina, AU - Ryan,Patrick H, AU - Biagini Myers,Jocelyn M, AU - Villareal,Manuel, AU - Burkle,Jeff, AU - Evans,Sherry, AU - Lockey,James E, AU - Khurana Hershey,Gurjit K, AU - Bernstein,David I, Y1 - 2014/12/10/ PY - 2014/06/26/received PY - 2014/10/08/revised PY - 2014/10/28/accepted PY - 2014/12/16/entrez PY - 2014/12/17/pubmed PY - 2015/4/24/medline SP - 126 EP - 33 JF - Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology JO - Ann. Allergy Asthma Immunol. VL - 114 IS - 2 N2 - BACKGROUND: No large, prospective, epidemiologic study has investigated the association between diesel exhaust particle (DEP) exposure and early aeroallergen sensitization and allergic rhinitis (AR) at 4 years of age. OBJECTIVE: To determine how exposure to traffic exhaust during infancy is associated with aeroallergen sensitization and AR at 4 years of age and the predictive utility of the wheal area at 1 to 3 years of age on AR at 4 years of age. METHODS: Infants born to aeroallergen sensitized parents were evaluated annually with skin prick tests to 15 aeroallergens with measurement of wheal areas. At 4 years of age, AR was defined as at least one positive aeroallergen skin prick test result and the presence of sneezing and a runny nose without a cold or flu. Infant (DEP) exposure was estimated using data from 27 air sampling monitors and a land use regression model. RESULTS: Complete data were available for 634 children at 4 years of age. Prevalence of AR increased annually from 6.9% to 21.9%. A positive trend was observed for high DEP exposure and aeroallergen sensitization at 2 and 3 years of age (odds ratio, 1.40; 95% confidence interval, 0.97-2.0) and (odds ratio, 1.35; 95% confidence interval, 0.98-1.85) but not with AR. At 2 years of age, every 1-mm(2) increase in the wheal area of timothy and Alternaria significantly increased the odds of AR at 4 years of age. At 3 years of age, every 1-mm(2) increase in the wheal area of fescue, dog, and Penicillium significantly increased the odds of AR at 4 years of age. CONCLUSION: DEP exposure enhances the risk of early aeroallergen sensitization. Aeroallergen wheal area at 2 and 3 years of age is associated with AR at 4 years of age. SN - 1534-4436 UR - https://www.unboundmedicine.com/medline/citation/25499550/Traffic_pollution_is_associated_with_early_childhood_aeroallergen_sensitization_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1081-1206(14)00756-X DB - PRIME DP - Unbound Medicine ER -