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Are low ultraviolet B and vitamin D associated with higher incidence of multiple myeloma?
J Steroid Biochem Mol Biol. 2015 Apr; 148:245-52.JS

Abstract

BACKGROUND

The purpose of this study was to determine whether an inverse association exists between latitude, solar ultraviolet B (UVB) irradiance, and incidence rates of multiple myeloma.Methods Associations of latitude and UVB irradiance with age-standardized incidence rates of multiple myeloma were analyzed for 175 countries while controlling for sex-specific obesity prevalence, cigarette consumption, and alcohol consumption using multiple linear regression.Results Incidence rates of multiple myeloma were greater at higher latitudes (R(2) for latitude for males=0.31, p<0.0001; females R(2)=0.27, p<0.0001). In regression models for males (R(2)=0.62, p<0.0001) and females (R(2)=0.51, p<0.0001), UVB irradiance was independently inversely associated with incidence rates.Conclusions Age-adjusted incidence rates of multiple myeloma were higher in countries with lower solar UVB irradiance. Further investigation is warranted in individuals of the association of prediagnostic serum 25(OH)D with risk.

Authors+Show Affiliations

Deartment of Family and Preventive Medicine, University of California, San Diego, La Jolla, CA, United States; Naval Health Research Center, San Diego, CA, United States.Deartment of Family and Preventive Medicine, University of California, San Diego, La Jolla, CA, United States; Naval Health Research Center, San Diego, CA, United States.Deartment of Family and Preventive Medicine, University of California, San Diego, La Jolla, CA, United States.Sunlight, Nutrition, and Health Research Center, San Francisco, CA, United States.Deartment of Family and Preventive Medicine, University of California, San Diego, La Jolla, CA, United States; Naval Health Research Center, San Diego, CA, United States.Deartment of Family and Preventive Medicine, University of California, San Diego, La Jolla, CA, United States; Graduate School of Public Health, San Diego State University, San Diego, CA, United States. Electronic address: raphael.e.cuomo@gmail.com.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

25500072

Citation

Mohr, Sharif B., et al. "Are Low Ultraviolet B and Vitamin D Associated With Higher Incidence of Multiple Myeloma?" The Journal of Steroid Biochemistry and Molecular Biology, vol. 148, 2015, pp. 245-52.
Mohr SB, Gorham ED, Garland CF, et al. Are low ultraviolet B and vitamin D associated with higher incidence of multiple myeloma? J Steroid Biochem Mol Biol. 2015;148:245-52.
Mohr, S. B., Gorham, E. D., Garland, C. F., Grant, W. B., Garland, F. C., & Cuomo, R. E. (2015). Are low ultraviolet B and vitamin D associated with higher incidence of multiple myeloma? The Journal of Steroid Biochemistry and Molecular Biology, 148, 245-52. https://doi.org/10.1016/j.jsbmb.2014.12.005
Mohr SB, et al. Are Low Ultraviolet B and Vitamin D Associated With Higher Incidence of Multiple Myeloma. J Steroid Biochem Mol Biol. 2015;148:245-52. PubMed PMID: 25500072.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Are low ultraviolet B and vitamin D associated with higher incidence of multiple myeloma? AU - Mohr,Sharif B, AU - Gorham,Edward D, AU - Garland,Cedric F, AU - Grant,William B, AU - Garland,Frank C, AU - Cuomo,Raphael E, Y1 - 2014/12/10/ PY - 2014/08/28/received PY - 2014/12/02/revised PY - 2014/12/03/accepted PY - 2014/12/16/entrez PY - 2014/12/17/pubmed PY - 2015/5/23/medline KW - Alcohol KW - Cigarettes KW - Incidence KW - International comparisons KW - Multiple regression KW - Myeloma KW - Ultraviolet rays KW - Vitamin D SP - 245 EP - 52 JF - The Journal of steroid biochemistry and molecular biology JO - J. Steroid Biochem. Mol. Biol. VL - 148 N2 - BACKGROUND: The purpose of this study was to determine whether an inverse association exists between latitude, solar ultraviolet B (UVB) irradiance, and incidence rates of multiple myeloma.Methods Associations of latitude and UVB irradiance with age-standardized incidence rates of multiple myeloma were analyzed for 175 countries while controlling for sex-specific obesity prevalence, cigarette consumption, and alcohol consumption using multiple linear regression.Results Incidence rates of multiple myeloma were greater at higher latitudes (R(2) for latitude for males=0.31, p<0.0001; females R(2)=0.27, p<0.0001). In regression models for males (R(2)=0.62, p<0.0001) and females (R(2)=0.51, p<0.0001), UVB irradiance was independently inversely associated with incidence rates.Conclusions Age-adjusted incidence rates of multiple myeloma were higher in countries with lower solar UVB irradiance. Further investigation is warranted in individuals of the association of prediagnostic serum 25(OH)D with risk. SN - 1879-1220 UR - https://www.unboundmedicine.com/medline/citation/25500072/Are_low_ultraviolet_B_and_vitamin_D_associated_with_higher_incidence_of_multiple_myeloma L2 - https://linkinghub.elsevier.com/retrieve/pii/S0960-0760(14)00311-2 DB - PRIME DP - Unbound Medicine ER -