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Effects of extracts of leaves from Sparattosperma leucanthum on hyperuricemia and gouty arthritis.
J Ethnopharmacol. 2015 Feb 23; 161:194-9.JE

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE

The species Sparattosperma leucanthum (Vell.) K. Schum is used in Brazilian folk medicine to treat rheumatism, throat ulcers, stomatitis, syphilis, bladder stones and as blood cleanser. The aim of this study was to evaluate the potential, in vitro and in vivo, of the extracts of leaves from Sparattosperma leucanthum to treat hyperuricemia and inflammation in the gouty arthritis model.

MATERIALS AND METHODS

Ethyl acetate extract (SLE), methanolic extract (SLM) and aqueous extract (SLW) were evaluated in vitro on XO inhibitory activity and in vivo in an experimental model with oxonate-induced hyperuricemia in mice which was used to evaluate anti-hyperuricemic activity and liver xanthine oxidase (XOD) inhibition. Anti-inflammatory activity was also investigated on MSU crystal-induced paw edema model.

RESULTS

Sparattosperma leucanthum crude extracts showed expressive results on urate-lowering activity in blood. SLW at the dose of 125 mg/kg has proved to be active in reducing hyperuricemia and was capable to inhibit the hepatic xanthine oxidase enzyme (XOD). SLM showed anti-hyperuricemic activity on all doses tested; however, this extract showed activity on the XOD only at the dose of 500 mg/kg. SLE, at the three evaluated doses, has proved to be active in reducing hyperuricemia in vivo and was able to inhibit XO activity in vitro at the concentration of 100 µg/mL. This extract was also able to inhibit XOD activity in vivo at the doses of 250 mg/kg and 500 mg/kg. SLE (125 and 250 mg/kg) and SLW (500 mg/kg) showed significant anti-inflammatory activity on monosodium urate crystal-induced paw edema model.

CONCLUSIONS

The ethyl acetate, methanolic and aqueous extracts of Sparattosperma leucanthum showed significant results on evaluated models and therefore may be important agents for the treatment of gouty arthritis and hyperuricemia.

Authors+Show Affiliations

Laboratório de Plantas Medicinais, Escola de Farmácia, Universidade Federal de Ouro Preto, Campus Morro do Cruzeiro, s/n. Ouro Preto, Minas Gerais CEP 35400-000, Brazil.Laboratório de Plantas Medicinais, Escola de Farmácia, Universidade Federal de Ouro Preto, Campus Morro do Cruzeiro, s/n. Ouro Preto, Minas Gerais CEP 35400-000, Brazil.Laboratório de Plantas Medicinais, Escola de Farmácia, Universidade Federal de Ouro Preto, Campus Morro do Cruzeiro, s/n. Ouro Preto, Minas Gerais CEP 35400-000, Brazil.Laboratório de Plantas Medicinais, Escola de Farmácia, Universidade Federal de Ouro Preto, Campus Morro do Cruzeiro, s/n. Ouro Preto, Minas Gerais CEP 35400-000, Brazil.Laboratório de Plantas Medicinais, Escola de Farmácia, Universidade Federal de Ouro Preto, Campus Morro do Cruzeiro, s/n. Ouro Preto, Minas Gerais CEP 35400-000, Brazil.Laboratório de Plantas Medicinais, Escola de Farmácia, Universidade Federal de Ouro Preto, Campus Morro do Cruzeiro, s/n. Ouro Preto, Minas Gerais CEP 35400-000, Brazil. Electronic address: saude@ef.ufop.br.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25500302

Citation

Lemos Lima, Rita de Cássia, et al. "Effects of Extracts of Leaves From Sparattosperma Leucanthum On Hyperuricemia and Gouty Arthritis." Journal of Ethnopharmacology, vol. 161, 2015, pp. 194-9.
Lemos Lima Rde C, Ferrari FC, de Souza MR, et al. Effects of extracts of leaves from Sparattosperma leucanthum on hyperuricemia and gouty arthritis. J Ethnopharmacol. 2015;161:194-9.
Lemos Lima, R. d. e. . C., Ferrari, F. C., de Souza, M. R., de Sá Pereira, B. M., de Paula, C. A., & Saúde-Guimarães, D. A. (2015). Effects of extracts of leaves from Sparattosperma leucanthum on hyperuricemia and gouty arthritis. Journal of Ethnopharmacology, 161, 194-9. https://doi.org/10.1016/j.jep.2014.11.051
Lemos Lima Rde C, et al. Effects of Extracts of Leaves From Sparattosperma Leucanthum On Hyperuricemia and Gouty Arthritis. J Ethnopharmacol. 2015 Feb 23;161:194-9. PubMed PMID: 25500302.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of extracts of leaves from Sparattosperma leucanthum on hyperuricemia and gouty arthritis. AU - Lemos Lima,Rita de Cássia, AU - Ferrari,Fernanda Cristina, AU - de Souza,Maíra Ribeiro, AU - de Sá Pereira,Bruna Maria, AU - de Paula,Carmen Aparecida, AU - Saúde-Guimarães,Dênia Antunes, Y1 - 2014/12/08/ PY - 2014/08/15/received PY - 2014/11/25/revised PY - 2014/11/29/accepted PY - 2014/12/16/entrez PY - 2014/12/17/pubmed PY - 2015/10/7/medline KW - Gout KW - Hyperuricemia KW - Inflammation KW - Sparattosperma leucanthum KW - Xanthine oxidase SP - 194 EP - 9 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 161 N2 - ETHNOPHARMACOLOGICAL RELEVANCE: The species Sparattosperma leucanthum (Vell.) K. Schum is used in Brazilian folk medicine to treat rheumatism, throat ulcers, stomatitis, syphilis, bladder stones and as blood cleanser. The aim of this study was to evaluate the potential, in vitro and in vivo, of the extracts of leaves from Sparattosperma leucanthum to treat hyperuricemia and inflammation in the gouty arthritis model. MATERIALS AND METHODS: Ethyl acetate extract (SLE), methanolic extract (SLM) and aqueous extract (SLW) were evaluated in vitro on XO inhibitory activity and in vivo in an experimental model with oxonate-induced hyperuricemia in mice which was used to evaluate anti-hyperuricemic activity and liver xanthine oxidase (XOD) inhibition. Anti-inflammatory activity was also investigated on MSU crystal-induced paw edema model. RESULTS: Sparattosperma leucanthum crude extracts showed expressive results on urate-lowering activity in blood. SLW at the dose of 125 mg/kg has proved to be active in reducing hyperuricemia and was capable to inhibit the hepatic xanthine oxidase enzyme (XOD). SLM showed anti-hyperuricemic activity on all doses tested; however, this extract showed activity on the XOD only at the dose of 500 mg/kg. SLE, at the three evaluated doses, has proved to be active in reducing hyperuricemia in vivo and was able to inhibit XO activity in vitro at the concentration of 100 µg/mL. This extract was also able to inhibit XOD activity in vivo at the doses of 250 mg/kg and 500 mg/kg. SLE (125 and 250 mg/kg) and SLW (500 mg/kg) showed significant anti-inflammatory activity on monosodium urate crystal-induced paw edema model. CONCLUSIONS: The ethyl acetate, methanolic and aqueous extracts of Sparattosperma leucanthum showed significant results on evaluated models and therefore may be important agents for the treatment of gouty arthritis and hyperuricemia. SN - 1872-7573 UR - https://www.unboundmedicine.com/medline/citation/25500302/Effects_of_extracts_of_leaves_from_Sparattosperma_leucanthum_on_hyperuricemia_and_gouty_arthritis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(14)00872-1 DB - PRIME DP - Unbound Medicine ER -