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Omega-3 polyunsaturated fatty acids and brain aging.
Curr Opin Clin Nutr Metab Care. 2015 Mar; 18(2):139-46.CO

Abstract

PURPOSE OF REVIEW

The literature on the influence of dietary omega-3 polyunsaturated fatty acid (ω-3 PUFA) on brain aging has grown exponentially during the last decade. Many avenues have been explored but no global picture or clear evidence has emerged. Experimental studies have shown that ω-3 PUFA is involved in many neurobiological processes that are involved in neurotransmission and neuroprotection, indicating that these PUFAs may prevent age-related brain damage. Human studies have revealed only a weak link between ω-3 PUFA status and cognitive aging, whereas interventional studies have yet to confirm it. The purpose of this review is to analyze the developments in the area during the last 2 years.

RECENT FINDINGS

Human brain MRI studies have confirmed previous findings that ω-3 PUFA can protect the brain during aging; two intervention studies obtained clear evidence. We also analyzed the experimental data clarifying the involvement of ω-3 PUFA in neurotransmission, neuroprotection (including prevention of peroxidation, inflammation, and excitotoxicity), and neurogenesis, thereby helping the brain cope with aging.

SUMMARY

These recent human and experimental studies provide support for and clarification of how ω-3 PUFA protect against brain aging and highlight the main lines for future research.

Authors+Show Affiliations

aUnité de Neurobiologie de l'Olfaction, NBO U1197, INRA, Jouy-en-Josas bINSERM UMR 894, Centre de Psychiatrie et Neurosciences, Paris cUnité MICALIS, UMR 1319, INRA, Jouy-en-Josas dUnité NutriNeurO, UMR INRA 1286, Université Victor Segalen Bordeaux 2, Bordeaux, France.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

25501348

Citation

Denis, Isabelle, et al. "Omega-3 Polyunsaturated Fatty Acids and Brain Aging." Current Opinion in Clinical Nutrition and Metabolic Care, vol. 18, no. 2, 2015, pp. 139-46.
Denis I, Potier B, Heberden C, et al. Omega-3 polyunsaturated fatty acids and brain aging. Curr Opin Clin Nutr Metab Care. 2015;18(2):139-46.
Denis, I., Potier, B., Heberden, C., & Vancassel, S. (2015). Omega-3 polyunsaturated fatty acids and brain aging. Current Opinion in Clinical Nutrition and Metabolic Care, 18(2), 139-46. https://doi.org/10.1097/MCO.0000000000000141
Denis I, et al. Omega-3 Polyunsaturated Fatty Acids and Brain Aging. Curr Opin Clin Nutr Metab Care. 2015;18(2):139-46. PubMed PMID: 25501348.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Omega-3 polyunsaturated fatty acids and brain aging. AU - Denis,Isabelle, AU - Potier,Brigitte, AU - Heberden,Christine, AU - Vancassel,Sylvie, PY - 2014/12/16/entrez PY - 2014/12/17/pubmed PY - 2015/9/25/medline SP - 139 EP - 46 JF - Current opinion in clinical nutrition and metabolic care JO - Curr Opin Clin Nutr Metab Care VL - 18 IS - 2 N2 - PURPOSE OF REVIEW: The literature on the influence of dietary omega-3 polyunsaturated fatty acid (ω-3 PUFA) on brain aging has grown exponentially during the last decade. Many avenues have been explored but no global picture or clear evidence has emerged. Experimental studies have shown that ω-3 PUFA is involved in many neurobiological processes that are involved in neurotransmission and neuroprotection, indicating that these PUFAs may prevent age-related brain damage. Human studies have revealed only a weak link between ω-3 PUFA status and cognitive aging, whereas interventional studies have yet to confirm it. The purpose of this review is to analyze the developments in the area during the last 2 years. RECENT FINDINGS: Human brain MRI studies have confirmed previous findings that ω-3 PUFA can protect the brain during aging; two intervention studies obtained clear evidence. We also analyzed the experimental data clarifying the involvement of ω-3 PUFA in neurotransmission, neuroprotection (including prevention of peroxidation, inflammation, and excitotoxicity), and neurogenesis, thereby helping the brain cope with aging. SUMMARY: These recent human and experimental studies provide support for and clarification of how ω-3 PUFA protect against brain aging and highlight the main lines for future research. SN - 1473-6519 UR - https://www.unboundmedicine.com/medline/citation/25501348/Omega_3_polyunsaturated_fatty_acids_and_brain_aging_ L2 - http://dx.doi.org/10.1097/MCO.0000000000000141 DB - PRIME DP - Unbound Medicine ER -