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Hereditary and common familial colorectal cancer: evidence for colorectal screening.
Dig Dis Sci. 2015 Mar; 60(3):734-47.DD

Abstract

Colorectal cancer (CRC) is the fourth most common cancer among men and women. Between 3 and 6% of all CRCs are attributed to well-defined inherited syndromes, including Lynch syndrome, familial adenomatous polyposis, MUTYH-associated polyposis and several hamartomatous conditions. Up to 30% of CRC cases exhibit common familial risk, likely related to a combination of inherited factors and environment. Identification of these patients through family history and appropriate genetic testing can provide estimates of cancer risk that inform appropriate cancer screening, surveillance and/or preventative interventions. This article examines the colon cancer syndromes, their genetic basis, clinical management and evidence supporting colorectal screening. It also deals with the category of common (non-syndromic) familial risk including risk determination and screening guidelines.

Authors+Show Affiliations

High Risk GI Cancers Program, Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope, Salt Lake City, UT, 84112, USA, jewel.samadder@hsc.utah.edu.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

25501924

Citation

Samadder, N Jewel, et al. "Hereditary and Common Familial Colorectal Cancer: Evidence for Colorectal Screening." Digestive Diseases and Sciences, vol. 60, no. 3, 2015, pp. 734-47.
Samadder NJ, Jasperson K, Burt RW. Hereditary and common familial colorectal cancer: evidence for colorectal screening. Dig Dis Sci. 2015;60(3):734-47.
Samadder, N. J., Jasperson, K., & Burt, R. W. (2015). Hereditary and common familial colorectal cancer: evidence for colorectal screening. Digestive Diseases and Sciences, 60(3), 734-47. https://doi.org/10.1007/s10620-014-3465-z
Samadder NJ, Jasperson K, Burt RW. Hereditary and Common Familial Colorectal Cancer: Evidence for Colorectal Screening. Dig Dis Sci. 2015;60(3):734-47. PubMed PMID: 25501924.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hereditary and common familial colorectal cancer: evidence for colorectal screening. AU - Samadder,N Jewel, AU - Jasperson,Kory, AU - Burt,Randall W, Y1 - 2014/12/12/ PY - 2014/07/17/received PY - 2014/11/24/accepted PY - 2014/12/16/entrez PY - 2014/12/17/pubmed PY - 2015/6/2/medline SP - 734 EP - 47 JF - Digestive diseases and sciences JO - Dig. Dis. Sci. VL - 60 IS - 3 N2 - Colorectal cancer (CRC) is the fourth most common cancer among men and women. Between 3 and 6% of all CRCs are attributed to well-defined inherited syndromes, including Lynch syndrome, familial adenomatous polyposis, MUTYH-associated polyposis and several hamartomatous conditions. Up to 30% of CRC cases exhibit common familial risk, likely related to a combination of inherited factors and environment. Identification of these patients through family history and appropriate genetic testing can provide estimates of cancer risk that inform appropriate cancer screening, surveillance and/or preventative interventions. This article examines the colon cancer syndromes, their genetic basis, clinical management and evidence supporting colorectal screening. It also deals with the category of common (non-syndromic) familial risk including risk determination and screening guidelines. SN - 1573-2568 UR - https://www.unboundmedicine.com/medline/citation/25501924/Hereditary_and_common_familial_colorectal_cancer:_evidence_for_colorectal_screening_ L2 - https://doi.org/10.1007/s10620-014-3465-z DB - PRIME DP - Unbound Medicine ER -