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Generalizability of the Proportional Recovery Model for the Upper Extremity After an Ischemic Stroke.
Neurorehabil Neural Repair 2015; 29(7):614-22NN

Abstract

BACKGROUND AND OBJECTIVE

Spontaneous neurological recovery after stroke is a poorly understood process. The aim of the present article was to test the proportional recovery model for the upper extremity poststroke and to identify clinical characteristics of patients who do not fit this model.

METHODS

A change in the Fugl-Meyer Assessment Upper Extremity score (FMA-UE) measured within 72 hours and at 6 months poststroke served to define motor recovery. Recovery on FMA-UE was predicted using the proportional recovery model: ΔFMA-UEpredicted = 0.7·(66 - FMA-UEinitial) + 0.4. Hierarchical cluster analysis on 211 patients was used to separate nonfitters (outliers) from fitters, and differences between these groups were studied using clinical determinants measured within 72 hours poststroke. Subsequent logistic regression analysis served to predict patients who may not fit the model.

RESULTS

The majority of patients (~70%; n = 146) showed a fixed proportional upper extremity motor recovery of about 78%; 65 patients had substantially less improvement than predicted. These nonfitters had more severe neurological impairments within 72 hours poststroke (P values <.01). Logistic regression analysis revealed that absence of finger extension, presence of facial palsy, more severe lower extremity paresis, and more severe type of stroke as defined by the Bamford classification were significant predictors of not fitting the proportional recovery model.

CONCLUSIONS

These results confirm in an independent sample that stroke patients with mild to moderate initial impairments show an almost fixed proportional upper extremity motor recovery. Patients who will most likely not achieve the predicted amount of recovery were identified using clinical determinants measured within 72 hours poststroke.

Authors+Show Affiliations

Department of Rehabilitation Medicine, MOVE Research Institute Amsterdam, VU University Medical Center, Amsterdam, The Netherlands.Department of Rehabilitation Medicine, MOVE Research Institute Amsterdam, VU University Medical Center, Amsterdam, The Netherlands e.vanwegen@vumc.nl.MOVE Research Institute Amsterdam, Faculty of Human Movement Sciences, VU University, Amsterdam, The Netherlands.Department of Rehabilitation Medicine, MOVE Research Institute Amsterdam, VU University Medical Center, Amsterdam, The Netherlands Department of Neurorehabilitation, Reade Centre for Rehabilitation and Rheumatology, Amsterdam, The Netherlands.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25505223

Citation

Winters, Caroline, et al. "Generalizability of the Proportional Recovery Model for the Upper Extremity After an Ischemic Stroke." Neurorehabilitation and Neural Repair, vol. 29, no. 7, 2015, pp. 614-22.
Winters C, van Wegen EE, Daffertshofer A, et al. Generalizability of the Proportional Recovery Model for the Upper Extremity After an Ischemic Stroke. Neurorehabil Neural Repair. 2015;29(7):614-22.
Winters, C., van Wegen, E. E., Daffertshofer, A., & Kwakkel, G. (2015). Generalizability of the Proportional Recovery Model for the Upper Extremity After an Ischemic Stroke. Neurorehabilitation and Neural Repair, 29(7), pp. 614-22. doi:10.1177/1545968314562115.
Winters C, et al. Generalizability of the Proportional Recovery Model for the Upper Extremity After an Ischemic Stroke. Neurorehabil Neural Repair. 2015;29(7):614-22. PubMed PMID: 25505223.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Generalizability of the Proportional Recovery Model for the Upper Extremity After an Ischemic Stroke. AU - Winters,Caroline, AU - van Wegen,Erwin E H, AU - Daffertshofer,Andreas, AU - Kwakkel,Gert, Y1 - 2014/12/11/ PY - 2014/12/16/entrez PY - 2014/12/17/pubmed PY - 2016/4/14/medline KW - prognosis KW - stroke KW - upper extremity SP - 614 EP - 22 JF - Neurorehabilitation and neural repair JO - Neurorehabil Neural Repair VL - 29 IS - 7 N2 - BACKGROUND AND OBJECTIVE: Spontaneous neurological recovery after stroke is a poorly understood process. The aim of the present article was to test the proportional recovery model for the upper extremity poststroke and to identify clinical characteristics of patients who do not fit this model. METHODS: A change in the Fugl-Meyer Assessment Upper Extremity score (FMA-UE) measured within 72 hours and at 6 months poststroke served to define motor recovery. Recovery on FMA-UE was predicted using the proportional recovery model: ΔFMA-UEpredicted = 0.7·(66 - FMA-UEinitial) + 0.4. Hierarchical cluster analysis on 211 patients was used to separate nonfitters (outliers) from fitters, and differences between these groups were studied using clinical determinants measured within 72 hours poststroke. Subsequent logistic regression analysis served to predict patients who may not fit the model. RESULTS: The majority of patients (~70%; n = 146) showed a fixed proportional upper extremity motor recovery of about 78%; 65 patients had substantially less improvement than predicted. These nonfitters had more severe neurological impairments within 72 hours poststroke (P values <.01). Logistic regression analysis revealed that absence of finger extension, presence of facial palsy, more severe lower extremity paresis, and more severe type of stroke as defined by the Bamford classification were significant predictors of not fitting the proportional recovery model. CONCLUSIONS: These results confirm in an independent sample that stroke patients with mild to moderate initial impairments show an almost fixed proportional upper extremity motor recovery. Patients who will most likely not achieve the predicted amount of recovery were identified using clinical determinants measured within 72 hours poststroke. SN - 1552-6844 UR - https://www.unboundmedicine.com/medline/citation/25505223/Generalizability_of_the_Proportional_Recovery_Model_for_the_Upper_Extremity_After_an_Ischemic_Stroke_ L2 - http://journals.sagepub.com/doi/full/10.1177/1545968314562115?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -