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Endoscopic gastric cancer screening and surveillance in high-risk groups.

Abstract

Gastric cancer remains a major cancer problem world-wide and future incidence will likely increase due to rapidly aging population demographics. Population-based screening is being undertaken in Korea and Japan, where gastric cancer incidence rates are high, and seems to be effective in reducing mortality from gastric cancer. However, such strategies are difficult to implement in countries with a low incidence or limited resources. Thus, screening strategies should be directed towards high-risk population subgroups. Gastric cancer has a relatively long mean sojourn time, and prognosis of early-stage disease is excellent. In general population, screening at 2-year interval in Korea seems to be effective for early-stage diagnosis. In subjects with atrophic gastritis or intestinal metaplasia, surveillance is recommended at 1 to 3 years intervals according to European and Japanese recommendation. Screening intervals for family members with sporadic gastric cancer has not yet been adequately evaluated, but 1-year interval is recommended for hereditary diffuse gastric cancer family-members. Gastric cancer patients treated by endoscopic resection are the highest-risk group, and 1-year interval surveillance can detect most metachronous gastric cancers at an early stage. Future gastric cancer surveillance strategies using endoscopy should be guided by risk-stratification assessment, and further refinement of optimal surveillance intervals is needed.

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  • Authors+Show Affiliations

    Center for Gastric Cancer, National Cancer Center, Goyang, Korea.

    Source

    Clinical endoscopy 47:6 2014 Nov pg 497-503

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    25505714

    Citation

    Choi, Il Ju. "Endoscopic Gastric Cancer Screening and Surveillance in High-risk Groups." Clinical Endoscopy, vol. 47, no. 6, 2014, pp. 497-503.
    Choi IJ. Endoscopic gastric cancer screening and surveillance in high-risk groups. Clin Endosc. 2014;47(6):497-503.
    Choi, I. J. (2014). Endoscopic gastric cancer screening and surveillance in high-risk groups. Clinical Endoscopy, 47(6), pp. 497-503. doi:10.5946/ce.2014.47.6.497.
    Choi IJ. Endoscopic Gastric Cancer Screening and Surveillance in High-risk Groups. Clin Endosc. 2014;47(6):497-503. PubMed PMID: 25505714.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Endoscopic gastric cancer screening and surveillance in high-risk groups. A1 - Choi,Il Ju, Y1 - 2014/11/30/ PY - 2014/11/10/received PY - 2014/11/10/accepted PY - 2014/12/16/entrez PY - 2014/12/17/pubmed PY - 2014/12/17/medline KW - Endoscopy KW - Screening KW - Stomach neoplasms KW - Surveillance SP - 497 EP - 503 JF - Clinical endoscopy JO - Clin Endosc VL - 47 IS - 6 N2 - Gastric cancer remains a major cancer problem world-wide and future incidence will likely increase due to rapidly aging population demographics. Population-based screening is being undertaken in Korea and Japan, where gastric cancer incidence rates are high, and seems to be effective in reducing mortality from gastric cancer. However, such strategies are difficult to implement in countries with a low incidence or limited resources. Thus, screening strategies should be directed towards high-risk population subgroups. Gastric cancer has a relatively long mean sojourn time, and prognosis of early-stage disease is excellent. In general population, screening at 2-year interval in Korea seems to be effective for early-stage diagnosis. In subjects with atrophic gastritis or intestinal metaplasia, surveillance is recommended at 1 to 3 years intervals according to European and Japanese recommendation. Screening intervals for family members with sporadic gastric cancer has not yet been adequately evaluated, but 1-year interval is recommended for hereditary diffuse gastric cancer family-members. Gastric cancer patients treated by endoscopic resection are the highest-risk group, and 1-year interval surveillance can detect most metachronous gastric cancers at an early stage. Future gastric cancer surveillance strategies using endoscopy should be guided by risk-stratification assessment, and further refinement of optimal surveillance intervals is needed. SN - 2234-2400 UR - https://www.unboundmedicine.com/medline/citation/25505714/full_citation L2 - https://dx.doi.org/10.5946/ce.2014.47.6.497 DB - PRIME DP - Unbound Medicine ER -