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Effects of anethole in nociception experimental models.

Abstract

This study investigated the antinociceptive activity of anethole (anethole 1-methoxy-4-benzene (1-propenyl)), major compound of the essential oil of star anise (Illicium verum), in different experimental models of nociception. The animals were pretreated with anethole (62.5, 125, 250, and 500 mg/kg) one hour before the experiments. To eliminate a possible sedative effect of anethole, the open field test was conducted. Anethole (62.5, 125, 250, and 500 mg/kg) showed an antinociceptive effect in the writhing model induced by acetic acid, in the second phase of the formalin test (125 and 250 mg/kg) in the test of glutamate (62.5, 125, and 250 mg/kg), and expresses pain induced by ACF (250 mg/kg). In contrast, anethole was not able to increase the latency time on the hot plate and decrease the number of flinches during the initial phase of the formalin test in any of the doses tested. It was also demonstrated that anethole has no association with sedative effects. Therefore, these data showed that anethole, at all used doses, has no sedative effect and has an antinociceptive effect. This effect may be due to a decrease in the production/release of inflammatory mediators.

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  • Authors+Show Affiliations

    ,

    Department of Pharmacology and Therapeutics, Laboratory of Inflammation, State University of Maringá, Avenida Colombo 5790, 87020-900 Maringá, PR, Brazil.

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    Department of Pharmacology and Therapeutics, Laboratory of Inflammation, State University of Maringá, Avenida Colombo 5790, 87020-900 Maringá, PR, Brazil.

    ,

    Department of Pharmacology and Therapeutics, Laboratory of Inflammation, State University of Maringá, Avenida Colombo 5790, 87020-900 Maringá, PR, Brazil.

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    Department of Pharmacology and Therapeutics, Laboratory of Brain Ischemia and Neuroprotection, State University of Maringá, Maringá, PR, Brazil.

    ,

    Department of Pharmacology and Therapeutics, Laboratory of Inflammation, State University of Maringá, Avenida Colombo 5790, 87020-900 Maringá, PR, Brazil.

    Department of Pharmacology and Therapeutics, Laboratory of Inflammation, State University of Maringá, Avenida Colombo 5790, 87020-900 Maringá, PR, Brazil.

    Source

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    25506382

    Citation

    Ritter, Alessandra Mileni Versuti, et al. "Effects of Anethole in Nociception Experimental Models." Evidence-based Complementary and Alternative Medicine : ECAM, vol. 2014, 2014, p. 345829.
    Ritter AM, Ames FQ, Otani F, et al. Effects of anethole in nociception experimental models. Evid Based Complement Alternat Med. 2014;2014:345829.
    Ritter, A. M., Ames, F. Q., Otani, F., de Oliveira, R. M., Cuman, R. K., & Bersani-Amado, C. A. (2014). Effects of anethole in nociception experimental models. Evidence-based Complementary and Alternative Medicine : ECAM, 2014, p. 345829. doi:10.1155/2014/345829.
    Ritter AM, et al. Effects of Anethole in Nociception Experimental Models. Evid Based Complement Alternat Med. 2014;2014:345829. PubMed PMID: 25506382.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Effects of anethole in nociception experimental models. AU - Ritter,Alessandra Mileni Versuti, AU - Ames,Franciele Queiroz, AU - Otani,Fernando, AU - de Oliveira,Rubia Maria Weffort, AU - Cuman,Roberto Kenji Nakamura, AU - Bersani-Amado,Ciomar Aparecida, Y1 - 2014/11/25/ PY - 2014/06/26/received PY - 2014/08/30/revised PY - 2014/09/01/accepted PY - 2014/12/16/entrez PY - 2014/12/17/pubmed PY - 2014/12/17/medline SP - 345829 EP - 345829 JF - Evidence-based complementary and alternative medicine : eCAM JO - Evid Based Complement Alternat Med VL - 2014 N2 - This study investigated the antinociceptive activity of anethole (anethole 1-methoxy-4-benzene (1-propenyl)), major compound of the essential oil of star anise (Illicium verum), in different experimental models of nociception. The animals were pretreated with anethole (62.5, 125, 250, and 500 mg/kg) one hour before the experiments. To eliminate a possible sedative effect of anethole, the open field test was conducted. Anethole (62.5, 125, 250, and 500 mg/kg) showed an antinociceptive effect in the writhing model induced by acetic acid, in the second phase of the formalin test (125 and 250 mg/kg) in the test of glutamate (62.5, 125, and 250 mg/kg), and expresses pain induced by ACF (250 mg/kg). In contrast, anethole was not able to increase the latency time on the hot plate and decrease the number of flinches during the initial phase of the formalin test in any of the doses tested. It was also demonstrated that anethole has no association with sedative effects. Therefore, these data showed that anethole, at all used doses, has no sedative effect and has an antinociceptive effect. This effect may be due to a decrease in the production/release of inflammatory mediators. SN - 1741-427X UR - https://www.unboundmedicine.com/medline/citation/25506382/Effects_of_anethole_in_nociception_experimental_models_ L2 - https://dx.doi.org/10.1155/2014/345829 DB - PRIME DP - Unbound Medicine ER -