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Variations in vascular mortality trends, 2001-2010, among 1.3 million women with different lifestyle risk factors for the disease.
Eur J Prev Cardiol 2015; 22(12):1626-34EJ

Abstract

AIMS

Vascular disease mortality has declined rapidly in most Western countries, against a background of improved treatments and falling prevalence of smoking, but rising obesity. We examined whether this decline differed by lifestyle risk factors for vascular disease.

METHODS AND RESULTS

During 2001-2010, there were 9241 vascular disease deaths in a prospective study of 1.3 million women in middle age, about one-quarter of all UK women in the eligible age range (50-64 years in 1996-2001). We estimated percentage declines in mortality from coronary heart disease, cerebrovascular disease and other vascular diseases, overall and by age, smoking, alcohol consumption, adiposity, physical activity, socioeconomic status and age at leaving school. Over 10 years, coronary heart disease mortality fell by half (52%), cerebrovascular disease mortality by two-fifths (42%) and other vascular disease mortality by one-fifth (22%). Lean women experienced greater declines in coronary heart disease mortality than overweight or obese women (70%, 48% and 26%, respectively; P < 0.001 for heterogeneity) and women in the highest and middle thirds of socioeconomic status experienced greater declines in other (non-coronary, non-cerebrovascular) vascular disease mortality than women in the lowest third (41% and 42% and -9%, respectively; P = 0.001). After accounting for multiple testing, there were no other significant differences in vascular mortality trends by any lifestyle risk factor, including by smoking status.

CONCLUSION

Vascular disease mortality trends varied in this cohort by adiposity and socioeconomic status, but not by smoking status or other lifestyle risk factors. Prevention and treatment of vascular disease appear not to have been equally effective in all subgroups of UK women.

Authors+Show Affiliations

Cancer Epidemiology Unit, University of Oxford, Oxford, UK ben.cairns@ceu.ox.ac.uk.Cancer Epidemiology Unit, University of Oxford, Oxford, UK.Cancer Epidemiology Unit, University of Oxford, Oxford, UK.Cancer Epidemiology Unit, University of Oxford, Oxford, UK.Cancer Epidemiology Unit, University of Oxford, Oxford, UK.Cancer Epidemiology Unit, University of Oxford, Oxford, UK.No affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25510657

Citation

Cairns, Benjamin J., et al. "Variations in Vascular Mortality Trends, 2001-2010, Among 1.3 Million Women With Different Lifestyle Risk Factors for the Disease." European Journal of Preventive Cardiology, vol. 22, no. 12, 2015, pp. 1626-34.
Cairns BJ, Balkwill A, Canoy D, et al. Variations in vascular mortality trends, 2001-2010, among 1.3 million women with different lifestyle risk factors for the disease. Eur J Prev Cardiol. 2015;22(12):1626-34.
Cairns, B. J., Balkwill, A., Canoy, D., Green, J., Reeves, G. K., & Beral, V. (2015). Variations in vascular mortality trends, 2001-2010, among 1.3 million women with different lifestyle risk factors for the disease. European Journal of Preventive Cardiology, 22(12), pp. 1626-34. doi:10.1177/2047487314563710.
Cairns BJ, et al. Variations in Vascular Mortality Trends, 2001-2010, Among 1.3 Million Women With Different Lifestyle Risk Factors for the Disease. Eur J Prev Cardiol. 2015;22(12):1626-34. PubMed PMID: 25510657.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Variations in vascular mortality trends, 2001-2010, among 1.3 million women with different lifestyle risk factors for the disease. AU - Cairns,Benjamin J, AU - Balkwill,Angela, AU - Canoy,Dexter, AU - Green,Jane, AU - Reeves,Gillian K, AU - Beral,Valerie, AU - ,, Y1 - 2014/12/15/ PY - 2014/11/10/received PY - 2014/11/20/accepted PY - 2014/12/17/entrez PY - 2014/12/17/pubmed PY - 2016/8/31/medline KW - Coronary heart disease KW - cerebrovascular disease KW - mortality KW - obesity KW - secular trends KW - smoking SP - 1626 EP - 34 JF - European journal of preventive cardiology JO - Eur J Prev Cardiol VL - 22 IS - 12 N2 - AIMS: Vascular disease mortality has declined rapidly in most Western countries, against a background of improved treatments and falling prevalence of smoking, but rising obesity. We examined whether this decline differed by lifestyle risk factors for vascular disease. METHODS AND RESULTS: During 2001-2010, there were 9241 vascular disease deaths in a prospective study of 1.3 million women in middle age, about one-quarter of all UK women in the eligible age range (50-64 years in 1996-2001). We estimated percentage declines in mortality from coronary heart disease, cerebrovascular disease and other vascular diseases, overall and by age, smoking, alcohol consumption, adiposity, physical activity, socioeconomic status and age at leaving school. Over 10 years, coronary heart disease mortality fell by half (52%), cerebrovascular disease mortality by two-fifths (42%) and other vascular disease mortality by one-fifth (22%). Lean women experienced greater declines in coronary heart disease mortality than overweight or obese women (70%, 48% and 26%, respectively; P < 0.001 for heterogeneity) and women in the highest and middle thirds of socioeconomic status experienced greater declines in other (non-coronary, non-cerebrovascular) vascular disease mortality than women in the lowest third (41% and 42% and -9%, respectively; P = 0.001). After accounting for multiple testing, there were no other significant differences in vascular mortality trends by any lifestyle risk factor, including by smoking status. CONCLUSION: Vascular disease mortality trends varied in this cohort by adiposity and socioeconomic status, but not by smoking status or other lifestyle risk factors. Prevention and treatment of vascular disease appear not to have been equally effective in all subgroups of UK women. SN - 2047-4881 UR - https://www.unboundmedicine.com/medline/citation/25510657/Variations_in_vascular_mortality_trends_2001_2010_among_1_3_million_women_with_different_lifestyle_risk_factors_for_the_disease_ L2 - http://journals.sagepub.com/doi/full/10.1177/2047487314563710?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -